Navigation Links
New Asthma Gene Identified

A gene that is strongly associated with a risk of developing childhood onset asthma was identified by an international team of scientists , whose findings are published today in the journal Nature.

In a genetic study of more than 2,000 children, scientists from the University of Michigan and colleagues from London, France and Germany found genetic markers that dramatically increase a child's risk for asthma.

These markers are located on chromosome 17, and children with this marker had higher levels of a new gene called ORMDL3 in their blood, which occurs in higher amounts in children with asthma. The presence of the disease-associated version of ORMDL3 increases the risk of asthma by 60-70 percent, the study suggests.

"In terms of an asthma gene, there have been quite a few reports but not one that can be clearly reproduced in samples," said Goncalo Abecasis, associate professor at the U-M School of Public Health. "I think eventually it will lead to new therapies because it points to a specific biological molecular pathway. Once we understand the biology and we know the players, it's possible to target with specific drugs."

Childhood asthma treatments are heavily focused on allergic responses, since most children with asthma also have many allergies. The discovery of a so-called 'asthma gene' would provide a new set of mechanisms to try and modify and manage childhood asthma, Abecasis said.

"Before we finished the paper, we would have guessed (ORMDL3) would be a gene with a well-understood role in allergic responses, but that is not what we found," said Abecasis, noting that the gene has no known relation to allergic responses.

Asthma, a complex disease caused by a combination of genetic and environmental factors, is the most common chronic disease of childhood. Asthma occurs in 7-10 percent of children in the United States and one child in seven in the United Kingdom.
'"/>




Page: 1 2 3

Related medicine news :

1. New Drug for Bronchial Asthma
2. Asthma may actually be prevented by Dust and Dirt
3. Inhaled Steroids Safe & Effective for Children with Asthma
4. What happens when Asthmatics consume Aspirin?
5. Asthma! A new warning for heart disease
6. Asthma linked to obesity
7. Higher Risk of Asthma in children with autoimmune disease
8. Asthmatics at increased risk of lung cancer
9. Cleanliness might lead to Asthma
10. Asthma is not just a childhood condition
11. Asthma not just a childhood condition
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Asthma Gene Identified

(Date:10/20/2014)... Succeed is proud to announce that they ranked ... the Every Body Walk! campaign by Kaiser Permanente. ... encourages workers to be more active outside of the workplace. ... at the end of September, was a friendly competition between ... Participating companies gave their staff pedometers and each day, ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 It’s hard to ... many orphans and vulnerable children around the world, it’s a ... some people, many children are forced to walk barefoot on ... their families or play with their friends. , Buckner ... with Air1 Radio in October to encourage support ...
(Date:10/19/2014)... 20, 2014 The leading review ... http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the best Dedicated ... for those who want to buy high quality ... , The IT manager of Top10BestSEOHosting.com says, “We ... recommended suppliers for everyone. A lot of the ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest hosting ranking ... are the best VPS hosting suppliers in the ... method of partitioning a physical server computer into ... and capabilities of running on someone’s own dedicated ... attention to VPS products and related suppliers. ...
(Date:10/19/2014)... (HealthDay News) -- New stem cell-based research could improve ... treatments, a new study suggests. Scientists used stem ... in a lab dish. They then transplanted the organoids ... disorders, according to the researchers. "This provides a ... that can cause intestinal failure, from genetic disorders appearing ...
Breaking Medicine News(10 mins):Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Scientists Grow, Implant Human Intestinal Tissue in Mice 2
... just no end to bizarre things that can happen in that ... ,A 3-year-old girl is attacked savagely by her mothers boyfriend, for ... treatment for the poor child, but she would not betray her ... arrested. ,,New Bedford police in Massachusetts announced Wednesday ...
... over 12 weeks pregnant with rocker boyfriend Joel Madden's baby, ... is reported to have shared the joyful news with her ... However, she is neither confirming nor denying her pregnancy to ... appears quite excited about a rumour that Madden might be ...
... A new research by a Frankfurt University team has ... and birds, also use the Earth's magnetic field to ... experiment, the team of Prof. Dr. Wolfgang Wiltschko and ... magnetic field, teaching them by intensive training that their ...
... AIDS awareness project called 'Jaago' to highlight the spread of ... ,The project, which is funded by the Bill and Melinda ... to inform people about AIDS and its impact. It will ... the disease during movie screenings. ,The internationally acclaimed ...
... at The University of Nottingham are amassing an arsenal of ... of hospital superbugs . ,It infiltrates hospitals as ... most antibiotics. And it kills three times as many people ... led by Professor Nigel Minton in the Centre for Healthcare ...
... conference of the European Society of Human Reproduction and ... for protecting the fertility of women with cancer ... Kate Stern, Research Director of the Royal Womens Hospital, ... had shown gonadotropin-releasing hormone (GnRH) antagonists were likely to ...
Cached Medicine News:Health News:Boyfriend Bites Off Lip and Ear of 3-year-old Daughter of His Girlfriend 2Health News:The Hospital Superbugs 2Health News:The Hospital Superbugs 3Health News:A New Therapy to Protect Cancer Patients Against Infertility 2
(Date:10/19/2014)... Oct. 19, 2014  Henry Schein, Inc. (NASDAQ: ... care products and services to office-based dental, animal health ... in Iwase Dental Supply, Inc., a leading full-service provider ... marks Henry Schein,s entrance into Japan ... and increases to 28 the number of countries in ...
(Date:10/17/2014)... Oct. 17, 2014 With the recent ... function has come across several challenges in creating ... managing globalization.  The Medical ... dedicated to providing benchmarking and best practices across ... is a service composed of three stages: 1) ...
(Date:10/17/2014)...  Amgen (NASDAQ: AMGN ) today announced ... president of Gladstone Institutes and Gladstone,s Robert W. and ... are pleased to welcome Dr. Sandy Williams ... , chairman and chief executive officer of Amgen. "Dr. ... his direct experience in our industry will both be ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Early Key Findings from the Medical Affairs Consortium Research 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3
... The 6060 MULTI-THERAPY Infusion ... of infusion profiles that ... reliable delivery. Designed for ... the 6060 MULTI-THERAPY Pump ...
... COLLEAGUE pumps can be customized with selectable ... care sites and therapies. The COLLEAGUE ... to be used for both gravity and ... costs. From simple infusions to medication therapies ...
... Pathology and Laboratory Medicine at the Cleveland ... most comprehensive academic medical center laboratories. With ... more than 40 pathologists and PhDs, our ... results, interpretations and diagnostic consultations annually. Our ...
Focus Diagnostics Reference Laboratory is known for quality infectious disease and autoimmune testing services. We offer over 1200 tests and panels and are continually adding new tests to our menu....
Medicine Products: