Navigation Links
New Antibody for EGFR Causes Lung Cancer Regression

Mutant forms of the protein EGFR are important for the development of lung cancer in a substantial proportion of individuals with this disease. However, not all individuals// express the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a mutation that affects the extracellular part of EGFR (known as the EGFRvIII mutant).

The potential of therapeutics to benefit individuals with lung cancer caused by the distinct EGFR mutants can be examined using two mouse models of lung cancer, one driven by expression of EGFR with a mutation in the intracellular part of the protein and one driven by expression of the EGFRvIII mutant.

In a study, Kwok-Kin Wong and colleagues from the Dana-Farber Cancer Institute in Boston show that a mouse antibody that binds EGFR (mAb806) causes the regression of lung tumors in both models of lung cancer.

By contrast, a second antibody that binds EGFR (cetuximab), and that is already in clinical use for the treatment of a specific subset of patients with lung cancer, only induced tumor regression in mice with lung tumors driven by expression of EGFR with a mutation in the intracellular part of the protein.

Importantly, the humanized form of mAb806 (ch806) caused regression of lung tumors in both models of lung cancer. The data presented in this study therefore indicate that ch806 might provide a new therapeutic for the treatment of patients with lung cancer driven by mutant forms of EGFR, in particular the EGFRvIII mutant.

Source-Eurekalert
'"/>




Page: 1

Related medicine news :

1. Human Antibody That Can Block SARS
2. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
3. Cuba Registers New Antibody
4. Single Sugar Enables Antibody to Treat Inflammation
5. Monoclonal Antibody based system for Anthrax detection
6. Monoclonal Antibody Reduces Exacerbations in Asthmatics
7. Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels
8. Antibody Therapy Prevents Type 1 Diabetes
9. J591- an Antibody Exclusively Targets Tumors
10. Breast Cancer Surgery Causes Psychological problems
11. Causes of weakness in the aged
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... ... ... Mill”: a story of love and redemption, hope and uncertainty as a girl makes ... “The Inn at the Mill” is the creation of published author, Lois Kulp, who was ... in Berks County on Crow Hill. The inn, the mill and "Post Yokel" ...
(Date:1/23/2017)... ... ... Infallible Characteristics of Christ”: a fascinating and entrancing novel exploring the gifts and ... author, Rev. Dr. Robert W. Thomas, the third of seven siblings. He was a ... pastor for over fifteen years. He is a graduate of N.C. College of Theology ...
(Date:1/22/2017)... California (PRWEB) , ... January 22, 2017 , ... "Photo ... Cloud to create a beautiful 3D slideshow with complete ease," said Christina Austin - ... Generators browser to place in the FCPX timeline. Presets include scenes with ...
(Date:1/21/2017)... ... 21, 2017 , ... "ProDOF is the perfect set of tools for video editors that want ... scene," said Christina Austin - CEO of Pixel Film Studios. , Video editors using ... illusion of a DSLR racking focus from one area into the next. ProDOF comes ...
(Date:1/21/2017)... (PRWEB) , ... January 21, 2017 , ... ... Redwood Family Dermatology has recently joined their multi-specialty medical group. The ... range of cosmetic services. , “We’re excited to add this excellent dermatology practice ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... NEW YORK , Jan. 23, 2017 MouthWatch ... Intraoral Camera was ranked as the best intraoral camera ... , taking the #2 spot overall. The #1 product was ... DentalCompare.com said the MouthWatch intraoral camera was "…incredibly popular because ... while the camera has a small sticker price, it doesn,t ...
(Date:1/23/2017)... 2017  Delcath Systems, Inc. (NASDAQ: DCTH ... of primary and metastatic liver cancers, today announced that ... and Chief Executive Officer of Delcath will be a ... Thirteenth Annual Investor Conference at the Boca Raton Resort ... , on Tuesday, January 31, 2017 at 10:30 am ...
(Date:1/23/2017)... SAN DIEGO , Jan. 23, 2017 /PRNewswire/ ... identify patients at high risk for acute kidney ... treatment recommended by globally-recognized care guidelines ... moderate to severe AKI more than 33 percent, ... weekend in the journal Intensive Care Medicine. ...
Breaking Medicine Technology: