Navigation Links
New Analytical Tool to Unravel the Cause of Diabetes

Researchers at the University of Wisconsin-Madison have designed a powerful analytical tool capable of measuring molecular structures quickly and accurately enough to catch moving proteins in mid-fold and see the shapes of intermediate steps.

And what has the chemists really excited, is that the first applications of the technique offer a glimpse into the contorted form of a human protein that is implicated in type II diabetes.

Pancreatic damage in type II diabetes has been linked to toxic clumps of the protein hIAPP (human islet amyloid polypeptide), which is normally produced by the same cells that make insulin.

An unknown trigger prompts the protein to fold into sharp fibers that poke holes in pancreatic cells, killing them.

Though scientists already have a good idea of the healthy "before" and dangerous "after" hIAPP structures, the steps in between remain somewhat of a mystery and may hold clues to what drives the transition.

Researchers led by UW-Madison chemistry professor Martin Zanni, used a method, known as two-dimensional infrared spectroscopy (2-D IR for short), that takes advantage of the restless nature of molecules and atoms to break down this dynamic process.

They obtained a single structural scan of hIAPP in less than a second - more than 500 times faster than previously possible.

This speed is crucial for trying to understand a dynamic process like hIAPP mis-folding, Zanni says.

The group now plans to capture series of snapshots during individual folding reactions to identify multiple phases as the proteins convert from an unordered mishmash into flat sheets, then coil into fibers.

"No matter how fast they're moving, we can take pictures of them. We need tools that not only allow us to probe the molecular structures, but also look at how the structures change in time," says Zanni.

Though often depicted as static blobs, proteins are more like collections of balls and springs, constantly in motion, and their endless atomic twitching conveys information about their organization. Infrared laser beams can detect the minute vibrations and identify characteristic patterns to deduce protein structures.

The technique also has potential application in other human diseases that involve protein mis-folding, such as Alzheimer's and Huntington's diseases.

The study appears in the online issue of the Proceedings of the National Academy of Sciences.


'"/>




Related medicine news :

1. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
2. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
3. Three Tropical Parasites Genetic Code Unravelled
4. Secret Of Heartbeat Protein Unravelled
5. Vietnamese Scientists Unravel Genetic Code Of Bird Flu Virus
6. A Step Towards Unraveling The Schizophrenia And Depression Mystery
7. Link Between Hepatitis C And Liver Cancer Unraveled By Scientists
8. $2.4 Million Grant To Unravel The Mystery Of Language Recognition.
9. Scientists Unravel Link Between HRT And Breast Cancer Gene, BRCA1
10. Mystery behind Complex Regional Pain Syndrome Unraveled
11. Novel Study Unravels a New Dimension to Decision Making
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2017)... , ... August 17, 2017 , ... A recent report ... the biopharmaceutical industry in 2016 cited deficiencies in data integrity. The FDA outlines their ... 11 ruling. , Presented as part of the Beckman Coulter Life Sciences ...
(Date:8/16/2017)... Bethpage, NY (PRWEB) , ... August 16, 2017 , ... ... Kullen, Long Island’s original family-owned supermarket, has put together suggestions for enjoying the season ... new recipe or activity, everyone in the family can join in on the fun. ...
(Date:8/16/2017)... ... 16, 2017 , ... Blue Health Intelligence (BHI) announced today that ... Dr. Spiro brings over 30 years of clinical, healthcare IT, value-based care, and change ... solutions. , “I am thrilled to welcome Dr. Spiro to BHI,” said Swati ...
(Date:8/16/2017)... SEATTLE, Washington and CARTERSVILLE, Georgia (PRWEB) , ... August 16, 2017 ... ... list of the fastest growing companies in the U.S. for the second year in ... shown strong growth over the past three years. , “To be on the list ...
(Date:8/16/2017)... FL (PRWEB) , ... August 16, 2017 , ... ... standardized product data and images announced today that it was acquired by Advantage ... Industry’s solution for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... 4, 2017 The search for test results ... physician/patient consult has long been the goal of healthcare ... focus of the largest meeting of lab professionals and ... market research firm Kalorama Information.  The firm said scores ... or related supplies and software were at the American ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital in ... team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, Tru-D ... UVC light energy to kill deadly pathogens such as C. diff , MRSA, MERS, ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
(Date:7/31/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), has been named one ... by Crain,s Detroit Business . The annual ... three-year revenue growth. This year,s edition measures growth from 2013 ... the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... said Phil Hagerman , CEO and chairman of Diplomat. ...
Breaking Medicine Technology: