Navigation Links
New "second-line" AIDS Drug Shows Promise in Trials

An experimental drug that researchers hope will cast a lifeline to HIV patients who have exhausted first-line treatment has shown early promise in long-awaited trials, The Lancet reports on Saturday.

Etravirine, also called TMC125, is designed as an alternative for patients who are resistant to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

An international consortium of doctors has been testing etravirine on NNRTI-resistant patients in two 48-week trials, the third and final phase of a long and complex process to assess new drugs for safety and effectiveness.

The volunteers in the DUET 1 and 2 trials are divided into two groups. Half receive etravrine and half a dummy, lookalike pill, a placebo.

In addition, all receive two standard anti-HIV drugs from a different treatment class, known as protease inhibitors, and also take selected NNRTIs.

The benchmark of success for helping patients with resistance problems is a "viral load" -- a count of the human immunodeficiency virus (HIV) which causes AIDS) -- to below 50 viruses per millilitre of blood.

At the 24-week point in the two trials, 56 and 62 percent of patients in the etravirine group had achieved this goal, The Lancet paper says. Among the "placebo" group, the rate was 39 and 44 percent.

Side effects were "mild or moderate" in severity, with generally little difference between the etravirine-takers and the placebo group.

Etravirine, made by a Belgian firm, Tibotec, has been closely followed by AIDS campaigners.

Antiretroviral drugs, as drugs to combat HIV are known, can save people with the AIDS virus, although they are not a cure.

But the longer a patient receives these drugs, the likelier it is that he or she will develop resistance problems as the virus mutates. In the case of NNRTIs, HIV can sidestep existing drugs with just a tiny mu tation in a single amino acid.

The treatment options narrow further if a patient is found to suffer bad side effects from these powerful molecules.

The hope for etravirine is that it will open up a new front against resistant virus and raise the genetic barrier to developing resistance.


'"/>




Related medicine news :

1. Experimental treatment for Ebola Virus Shows promising results in mice
2. New Prostate Cancer Vaccine Shows Promise
3. Ebola Treatment Shows Promise
4. New Drug Shows Significant Improvement In HIV-related Heart Condition
5. Greek Study Shows Living In The Hills May Be Healthier
6. Research Shows Carbon Monoxide Prevents Inflammations
7. Latest Research Shows That Multivitamins Might Not Prevent Infections In All Elderly
8. Novartis MS Drug Shows Promising Results
9. MRI Shows Emotional Changes During Menstrual Cycle
10. Bronchiolo-alveolar Carcinoma Shows Sonographic Pattern Of Pneumonia
11. AIDS drug GS 9137 Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2017)... ... January 24, 2017 , ... The Cradle to ... Agency (EPA) in its new recommendations of standards and ecolabels for ... announced. , Cradle to Cradle Certified is recommended at the highest level across ...
(Date:1/24/2017)... ... January 24, 2017 , ... In comments submitted ... (PCORI) for developing a data access and sharing policy. The nation’s leading biomedical ... plan as part of award applications, and earmarking specified amounts of grant funding ...
(Date:1/24/2017)... ... January 24, 2017 , ... i2i Population Health, a national leader in population ... , “Cary’s broad financial background is an excellent fit for i2i,” says Justin ... financial operations skills we need to take the company to the next level of ...
(Date:1/24/2017)... ... 24, 2017 , ... Seceon , the only threat ... today announced a strategic partnership with Paramount , the Middle East’s regional ... their critical information assets and infrastructure, in a comprehensive and cost effective manner. ...
(Date:1/24/2017)... ... 2017 , ... Center for Hispanic Leadership (CHL) Academy , the talent ... Manager, Employee & Labor Relations at City of Hope , a world-renowned independent ... Month. City of Hope is committed to stay out in front of its communities’ ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... and PUNE, India , January ... published by Allied Market Research, titled, "Cold Chain Logistics ... Confectionary, Dairy & Frozen Dessert, Meat, Fish & Sea ... Analysis and Industry Forecasts, 2014-2022," projects that the global ... million by 2022, growing at a CAGR of 16% ...
(Date:1/24/2017)... , Jan. 24, 2017 Regeneron Pharmaceuticals, ... the Public today recognized 40 finalists in the Regeneron ... science and math competition for high school seniors. Finalists ... potential of their research projects. The finalists ... from March 9-15 to undergo a rigorous judging ...
(Date:1/24/2017)... -- Research and Markets has announced the addition of ... Material - Forecast to 2025" report to their offering. ... The Global Implantable ... around 5.4% over the next decade to reach approximately $54.28 billion ... market is witnessing include 3D medical printing is expected to develop ...
Breaking Medicine Technology: