Navigation Links
Neurobiology Provides Answers To Block Memory-Related Drug Cravings

Drug addiction can be better handled following discovery of a novel chemical compound that blocks memory-related drug cravings. The finding has all the potential to be the basis of new therapies to aid drug-addiction recovery efforts // according to neurobiologists.

Because exposure to people, places and objects previously associated with a drug habit can trigger overwhelming memory-based cravings, many former drug users often relapse into drug-taking behavior.

Research has shown that memory for places associated with cocaine use can be strikingly altered by inactivating a specific protein called ERK (extra cellular signal-regulated kinase) in the brains of animals. Especially significant is the finding that administering the inactivator compound immediately after recall of the cocaine-associated places also continued to blur memories of those places weeks later. This research provides novel insights into the brain mechanisms underlying relapse and suggests a new strategy for developing addiction treatments. The study employed rats that shuttled between two distinctive environments, one which offered cocaine. Because of the drug’s strong rewarding properties, these animals quickly learned which of the two compartments was associated with the cocaine and preferred to spend time in that environment.

The researchers were then able to block the rats’ strong memory for the cocaine-associated environment by infusing a drug that inactivates ERK – a chemical compound called U0126 – into a brain region that rewards learning. Most importantly, this inhibitory effect was long lasting, with the memory blocked for at least two weeks after the single infusion.

The finding also suggests that memories responsible for relapse in drug addicts may be similarly disrupted by a therapeutic agent targeting ERK or related proteins. This work, however, is a first step toward subsequent efforts that can produce effective drug-addiction therapies.

'"/>




Page: 1 2

Related medicine news :

1. Drug Spironolactone Provides Renal And Cardioprotection In Diabetic Patients
2. London Hospital Provides Specialized Care For Pregnant Women
3. Breastfeeding Provides Added Protection To Babies
4. Far East Provides A Path To Contain Bird Flu
5. Direct To Home: Television Provides Powerful Fillip to Smoking Cessation Campaigns.
6. Latest Version of Echocardiography Provides Improved Pictures of the Heart
7. Hearing May Be Regained: Research Provides Hopes
8. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
9. Food Safety Extension Specialist Provides Spinach E. coli Advice
10. A New Approach to Heart Bypass Surgery Provides Patients with One-stop Shopping
11. Rajasthan Government Provides Free Dengue Tests for Patients
Post Your Comments:
(Date:7/24/2014)... THURSDAY, July 24, 2014 (HealthDay News) -- A new ... abusers from snorting or injecting the drug has been ... Called Targiniq ER and made by Purdue Pharma, the ... naloxone, a drug that blocks the euphoric effects of ... is crushed, snorted, dissolved or injected, according to the ...
(Date:7/24/2014)... Annual National Venous Interventional Summit is available at: ... established Venous Endovascular Interventional Strategies group comprised of ... to provide a "How To" meeting for cardiologists ... advancing their knowledge and skills in venous interventions ... comprehensive venous interventional program. Topics at this year,s ...
(Date:7/24/2014)... 2014 ACRIA & AMIDA CARE TO COHOST ... , Save the Dates: August 7th & August 8th* ... cohost “A Dialogue for Life” forums this August, led by ... Office of National AIDS Policy (ONAP). This will be a ... locally by AIDS organizations, consumers and advocates to advance the ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 National Analysts ... announced that it will operate globally under the name, ... remains a woman-owned Employee Stock Ownership Plan (ESOP) organization ... Schwartz McDonald, Ph.D . The firm guides market ... powerful analytics. , Said McDonald, “We wanted our ...
(Date:7/24/2014)... July 24, 2014 For the first time in ... United States. The Scottish singer first became a known musical commodity ... Her first song on the show was “I Dreamed a Dream,” ... released five studio albums since her time on the reality show ... in front of her American fans. The tour will kick off ...
Breaking Medicine News(10 mins):Health News:FDA Approves Hard-to-Abuse Narcotic Painkiller 2Health News:Preliminary agenda available for 4th VEINS Conference to be held October 9-12 in Chicago 2Health News:White House Office of National AIDS Policy Hosts Public Forums in NYC Aug. 7 and 8, Sponsored by Amida Care and ACRIA 2Health News:White House Office of National AIDS Policy Hosts Public Forums in NYC Aug. 7 and 8, Sponsored by Amida Care and ACRIA 3Health News:National Analysts Worldwide Announces a Change of Name to NAXION 2Health News:National Analysts Worldwide Announces a Change of Name to NAXION 3Health News:Susan Boyle Tickets: Dazzling Deals Tickets Cuts Ticket Prices for Susan Boyle's 2014 North America Concert Tour 2Health News:Susan Boyle Tickets: Dazzling Deals Tickets Cuts Ticket Prices for Susan Boyle's 2014 North America Concert Tour 3Health News:Susan Boyle Tickets: Dazzling Deals Tickets Cuts Ticket Prices for Susan Boyle's 2014 North America Concert Tour 4
... coverage with 99.99% ... captioning uptime, CANONSBURG, ... watched news reports, exit polls, and,election results for hundreds of national, ... networks and local stations,across the country, VITAC realtime captioners provided English ...
... financial advisor with,Minneapolis-based North Star Resource Group, has been ... Doctors" in 2008. The list of,top advisors will appear ... on,nominations from clients and survey data completed by advisors., ... said Dave,Vasos, co-president and chief financial officer of North ...
... The,patient-centered medical home, personal health records and emergency,department ... "Best in,Medicine" conference presented by the Michigan State Medical ... 3:30 p.m. at The Inn at St. John,s,in Plymouth., ... benefits and,cost-savings of the emerging health care model that ...
... Quarter Highlighted by Submission of NDA for Novel Antidepressant and ... Steady Global Growth for Once-Daily Tramadol - ... DDS;,NASDAQ: DDSS) today reported its results for the third quarter ... otherwise,stated., "We are very pleased with the progress of ...
... 7 EntreMed, Inc.,(Nasdaq: ENMD ) a ... cancer and inflammatory diseases,announced today that James S. ... Company update at the Rodman and Renshaw 10th ... 2008 at the New,York Palace Hotel in New ...
... same quarter in Fiscal 2008 -, (all ... BELLEVILLE, ON, Nov. 7 /PRNewswire-FirstCall/ - Bioniche ... company, today announced financial results for the first,quarter ... 2008., "Our revenues are up by 37% ...
Cached Medicine News:Health News:Flawless Captioning Service Brings Obama Victory and Speech to Deaf and Hard-Of-Hearing Viewers 2Health News:Andy Tate, North Star Resource Group Advisor, Named One of Medical Economics' '150 Best Financial Advisors for Doctors' 2Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 2Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 3Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 4Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 5Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 6Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 7Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 8Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 9Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 10Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 11Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 12Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 13Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 14Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 15Health News:Labopharm Reports Results for Third Quarter Fiscal 2008 16Health News:EntreMed to Present at the Rodman and Renshaw 10th Annual Healthcare Conference 2Health News:Bioniche Reports Fiscal 2009 First Quarter 2Health News:Bioniche Reports Fiscal 2009 First Quarter 3Health News:Bioniche Reports Fiscal 2009 First Quarter 4Health News:Bioniche Reports Fiscal 2009 First Quarter 5Health News:Bioniche Reports Fiscal 2009 First Quarter 6Health News:Bioniche Reports Fiscal 2009 First Quarter 7Health News:Bioniche Reports Fiscal 2009 First Quarter 8Health News:Bioniche Reports Fiscal 2009 First Quarter 9Health News:Bioniche Reports Fiscal 2009 First Quarter 10Health News:Bioniche Reports Fiscal 2009 First Quarter 11Health News:Bioniche Reports Fiscal 2009 First Quarter 12
(Date:7/24/2014)... Boston Children,s Hospital,s Global Pediatric Summit + ... an "Innovation Tank" – a forum designed to give ... business or product solution to a panel of acclaimed ... to accelerate the innovation and bring it to market. ... October 31, will be moderated by Daymond John ...
(Date:7/24/2014)... , July 24, 2014  To help ... cardiovascular market that could impact patient care and ... 2014 CV Watch , "Innovations in Cardiovascular Devices."  ... hospitals with guidance and details on promising new ... needs and understand how these options impact the ...
(Date:7/24/2014)... part of its ongoing effort to help women pharmacists become ... Boot Camp on July 26 as part of the company,s ... The Boot Camp is designed to ... their own pharmacies.  Now in its third year, the Cardinal ... pharmacists who dream of owning a pharmacy.   ...
Breaking Medicine Technology:Taking on Tomorrow to Feature "Innovation Tank" Pitch Opportunity for Aspiring Pediatric Health Care Entrepreneurs 2Taking on Tomorrow to Feature "Innovation Tank" Pitch Opportunity for Aspiring Pediatric Health Care Entrepreneurs 3New Novation CV Watch Shows Recent Technology Innovations Could Drive Cardiovascular Product Costs Up by as Much as 35 Percent 2New Novation CV Watch Shows Recent Technology Innovations Could Drive Cardiovascular Product Costs Up by as Much as 35 Percent 3'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 2'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 3'Women in Pharmacy' Program Seeks to Expand Pharmacy Ownership 4
... Association of Clinical Research Organizations (ACRO), which represents the ... and the public in the U.S. and worldwide, issued ... Implications of the Globalization of Clinical Research" published in ... England Journal of Medicine : The article by ...
... Journal of Medicine employs Quest Diagnostics, blood-based leukemia testingMADISON, ... specimens may detect abnormal white blood cells in patients ... develops, according to research published in the current issue ... Medicine . The finding may lead to a better ...
Cached Medicine Technology:ACRO Comments on NEJM Article on Globalization of Clinical Research 2ACRO Comments on NEJM Article on Globalization of Clinical Research 3Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis 2Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis 3Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: