Navigation Links
Neurobiology Provides Answers To Block Memory-Related Drug Cravings

Drug addiction can be better handled following discovery of a novel chemical compound that blocks memory-related drug cravings. The finding has all the potential to be the basis of new therapies to aid drug-addiction recovery efforts // according to neurobiologists.

Because exposure to people, places and objects previously associated with a drug habit can trigger overwhelming memory-based cravings, many former drug users often relapse into drug-taking behavior.

Research has shown that memory for places associated with cocaine use can be strikingly altered by inactivating a specific protein called ERK (extra cellular signal-regulated kinase) in the brains of animals. Especially significant is the finding that administering the inactivator compound immediately after recall of the cocaine-associated places also continued to blur memories of those places weeks later. This research provides novel insights into the brain mechanisms underlying relapse and suggests a new strategy for developing addiction treatments. The study employed rats that shuttled between two distinctive environments, one which offered cocaine. Because of the drug’s strong rewarding properties, these animals quickly learned which of the two compartments was associated with the cocaine and preferred to spend time in that environment.

The researchers were then able to block the rats’ strong memory for the cocaine-associated environment by infusing a drug that inactivates ERK – a chemical compound called U0126 – into a brain region that rewards learning. Most importantly, this inhibitory effect was long lasting, with the memory blocked for at least two weeks after the single infusion.

The finding also suggests that memories responsible for relapse in drug addicts may be similarly disrupted by a therapeutic agent targeting ERK or related proteins. This work, however, is a first step toward subsequent efforts that can produce effective drug-addiction therapies.

'"/>




Page: 1 2

Related medicine news :

1. Drug Spironolactone Provides Renal And Cardioprotection In Diabetic Patients
2. London Hospital Provides Specialized Care For Pregnant Women
3. Breastfeeding Provides Added Protection To Babies
4. Far East Provides A Path To Contain Bird Flu
5. Direct To Home: Television Provides Powerful Fillip to Smoking Cessation Campaigns.
6. Latest Version of Echocardiography Provides Improved Pictures of the Heart
7. Hearing May Be Regained: Research Provides Hopes
8. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
9. Food Safety Extension Specialist Provides Spinach E. coli Advice
10. A New Approach to Heart Bypass Surgery Provides Patients with One-stop Shopping
11. Rajasthan Government Provides Free Dengue Tests for Patients
Post Your Comments:
(Date:1/22/2015)... California (PRWEB) January 22, 2015 The City of ... at 10 a.m., to commemorate the 42nd anniversary of the Supreme ... States. , “It’s been 42 years since the Roe vs. Wade ... is still as present as ever,” said City of West Hollywood ...
(Date:1/22/2015)... January 22, 2015 Gabe’s Chemo Duck Program is ... the first app ever created for kids with cancer. The Chemo ... and devices, is filled with enjoyable games to help children of ... The free app helps to keep kids entertained, educated and at ...
(Date:1/22/2015)... a seasoned and trusted leader who consistently delivers trendy dresses ... it lead the wedding dress industry into the future. Today, ... the global market. , “The CEO of VogueQueen is uniquely ... continuing the goal of operational excellence and giving back to ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... Swiss Villa Dairy Farm in Lykens, Dauphin County, has ... of raw milk on Feb. 24, Agriculture Secretary Dennis ... not been pasteurized. Pennsylvania farms selling raw milk ... laboratory tested due to the health risks associated with ...
... American Medical Association and others have called for greater ... some big pharma companies have recently moved to better ... by third-party vendors), 75 - 100 percent of CME ... funded by the bio-pharma industry. As one interviewed VP ...
... SAN DIEGO, Feb. 24 XIFIN Inc., the ... laboratories, announced today that it has added two ... help guide the company,s rapid growth.(Logo: ... Officer. Mr. Zaniboni has most recently served as ...
... As we gear up for spring, the winter storms ... reminder that emergency situations can occur without warning. To ... the American Public Health Association,s (APHA) "Get Ready: Set ... update their emergency preparedness kits when they change their ...
... with the least education have a higher incidence of lung ... history accounts for approximately half of this risk, according to ... Journal of the National Cancer Institute. , Previous ... a higher risk for developing lung cancer. Some studies have ...
... of Differential Gene Expression in Patients After Supplement ... prostate biopsy samples taken from surgically removed prostate ... can be used to investigate their effects on ... samples from patients who had taken vitamin E, ...
Cached Medicine News:Health News:Educating the Market: Creating Value Through Support of Continuing Medical Education 2Health News:XIFIN Inc. Expands Its Executive Management Team 2Health News:Check Your Emergency Stocks When You Change Your Clocks, Says APHA 2Health News:Smoking behavior partially explains socioeconomic inequities in lung cancer incidence 2Health News:Also in the Feb. 24 JNCI 2Health News:Also in the Feb. 24 JNCI 3Health News:Also in the Feb. 24 JNCI 4
(Date:1/23/2015)... Jan. 23, 2015 More than a third of reproductive-aged ... those with private insurance, filled a prescription for an opioid ... in this week,s Morbidity and Mortality Weekly Report (MMWR). ... to treat moderate to severe pain.  They are also found ...
(Date:1/23/2015)... available for sale, The Armor1 Ankle Roll Guard is a ... by cushioning the ankle from an inversion or "roll." ... of any shoe type and allows the user to ... against sprains. With customers in physical therapy, podiatry, and ...
(Date:1/23/2015)... MONMOUTH JUNCTION, N.J. , Jan. 23, 2015 ... immunotherapy company commercializing its CytoSorb® extracorporeal cytokine adsorber ... surgery patients, announced the receipt of $385,642, net ... approved participant of the Technology Business Tax Certificate ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... -- WuXi PharmaTech (NYSE: WX ), ... development outsourcing company, with operations in China and ... in a negotiated transaction agreed to purchase from ... Atlantic LLC ("General Atlantic") all of the WuXi ...
...  Mercy Jets has announced it will make contributions to ... of Heart Month, the  air ambulance  transportation and medical ... and heart-related health. While the  medical transport ... non-profit organizations, Mercy Jets will donate twice that amount ...
Cached Medicine Technology:WuXi PharmaTech Announces Purchase of Ordinary Shares from General Atlantic 2Mercy Jets Celebrates Heart Month With Charitable Donations 2
... Technology Coronary Stent System provides enhanced ... Technology stent retention system features distal ... the stent for added security during ... minimize balloon overhang and to provide ...
Increased stent scaffolding at the proximal end gives optimal lumen support and 6F guide catheter compatibility and improved tracking offer excellent deliverability. Customized balloon lengths for ea...
For support, strength and control in your interventions, the RunWay Guide Catheter's large lumen and high-performance design represents a new era in guide catheters....
... over Guidants 20-year history, the VOYAGER RX ... successful treatment outcomes. It combines a new ... lower profile shaft,more flexible markers, and short ... tight and tortuous anatomy with even greater ...
Medicine Products: