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Neurobiology Provides Answers To Block Memory-Related Drug Cravings

Drug addiction can be better handled following discovery of a novel chemical compound that blocks memory-related drug cravings. The finding has all the potential to be the basis of new therapies to aid drug-addiction recovery efforts // according to neurobiologists.

Because exposure to people, places and objects previously associated with a drug habit can trigger overwhelming memory-based cravings, many former drug users often relapse into drug-taking behavior.

Research has shown that memory for places associated with cocaine use can be strikingly altered by inactivating a specific protein called ERK (extra cellular signal-regulated kinase) in the brains of animals. Especially significant is the finding that administering the inactivator compound immediately after recall of the cocaine-associated places also continued to blur memories of those places weeks later. This research provides novel insights into the brain mechanisms underlying relapse and suggests a new strategy for developing addiction treatments. The study employed rats that shuttled between two distinctive environments, one which offered cocaine. Because of the drug’s strong rewarding properties, these animals quickly learned which of the two compartments was associated with the cocaine and preferred to spend time in that environment.

The researchers were then able to block the rats’ strong memory for the cocaine-associated environment by infusing a drug that inactivates ERK – a chemical compound called U0126 – into a brain region that rewards learning. Most importantly, this inhibitory effect was long lasting, with the memory blocked for at least two weeks after the single infusion.

The finding also suggests that memories responsible for relapse in drug addicts may be similarly disrupted by a therapeutic agent targeting ERK or related proteins. This work, however, is a first step toward subsequent efforts that can produce effective drug-addiction therapies.

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