Navigation Links
Neural Stem Cells Reduce Parkinsons Symptoms in Monkeys

New Haven, Conn. Primates with severe Parkinsons disease were able to walk, move, and eat better, and had diminished tremors after being injected with human neural stem cells, a research team from Yale , Harvard, the University of Colorado, and the Burnham Institute report today in Proceedings of the National Academy of Sciences.

These results are promising, but it will be years before it is known whether a similar procedure would have therapeutic value for humans, said the lead author, D. Eugene Redmond Jr., professor of psychiatry and neurosurgery at Yale.

Not only are stem cells a potential source of replacement cells, they also seem to have a whole variety of effects that normalize other abnormalities, Redmond said. The human neural stem cells implanted into the primates survived, migrated, and had a functional impact. Its an important step, but there are a number of studies that need to be done before determining if this would be of any value in clinical settings.

Parkinsons disease is caused by a degeneration of dopamine neurons in an area of the midbrain known as the substantia nigra, which is responsible for dopamine production. Reduced production of dopamine in late stage Parkinsons causes symptoms such as severe difficulty in walking, fewer movements, delays in moving, lack of appetite, difficulty eating, periods of remaining motionless known as freezing, and head and limb tremors.

In this study five of eight monkeys with advanced Parkinsons were injected with human neural stem cells and three received sham injections. The monkeys were observed four months before and four months after surgery.

Those injected with human neural stem cells improved progressively for the entire post-treatment period and were significantly different from the monkeys that received sham injections. Twenty-one additional monkeys were studied for up to eight months for other biological effects of the stem cell s. No tumors or toxic effects were found.

Redmond said a small number of the human neural stem cell progeny differentiated into neurons that contained tyrosine hydroxylase and dopamine transporter. Cell progeny containing these markers suggest that the microenvironment within and around the brain lesions still permits development of a dopamine phenotype by responsive progenitor cells. The stem cells also made a growth factor that has been shown to improve dopamine function.

The neural stem cells are derived from fetal brain and are not embryonic stem cells. Monkeys with chimeric human neural cell-bearing brain regions showed no indication of behaviors that were not typical of the species.


'"/>




Related medicine news :

1. Gamma Knife Offers New Hope For Trigeminal Neuralgia Patients
2. Botox Relieves Neuralgic Pain
3. Fetal Neural Grafts Improves Motor and Cognitive Function in Huntington Patients
4. A boon to the paralyzed -Brain Gate Neural Interface System
5. Research Reveal A New Angle On Neural Circuits.
6. Neural Basis of Anxiety: Newer Insights
7. Blood Cells Capable of Regenerating Liver
8. White Cells Count Can Predict Heart Attack Death Risk
9. Gene Therapy Destroys Pancreatic Cancer Cells
10. Stem Cells Have Few Mutations
11. Heart may pull Cells from Body to Self-repair
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... 24, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is pleased to ... Road. The clinic is the group’s 7th location in San Antonio and 23rd in ... will provide care from the clinic, which opened March 22, 2017. , ...
(Date:3/24/2017)... ... March 24, 2017 , ... In just two days, Aqua ... micro-veggies garden on Kickstarter . Surpassing the $100,000 milestone so quickly,10-times the ... consumers (and counting) already backing the campaign. , “We are very grateful ...
(Date:3/24/2017)... NY (PRWEB) , ... March 24, 2017 , ... The ... and White Plains, N.Y., is pleased to announce Westchester resident Lauren C. Enea has ... law clerk for the firm, will concentrate her practice in elder law, Medicaid planning ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate ... during what is often a very difficult and challenging time.” , A Certified ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of Saints: A ... God in congregations across the United States. “The Communion of Saints” is ... who has served congregations in seven states throughout his long career of devotion ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , Mar. 24, 2017 Research ... Management in the U.S.: Consumer Strategies" report to their ... ... how adults approach and treat their physical pain, emphasizing consumer ... distinct groups: pain sufferers and adults who have selected illnesses/conditions ...
(Date:3/24/2017)... FinancialBuzz.com News Commentary  ... According to new data ... research, the legal cannabis market is projected to continue to ... signals from the current presidential administration. The report created by ... drivers of growth in this industry are the passage and ...
(Date:3/24/2017)... , March 24, 2017 A ReportsnReports.com ... has been growing rapidly as the global sales of Adcetris and ... growth in the antibody drug conjugates market is driven by large ... cancer and wider therapeutic window offered by ADCs. ... Browse 3 Tables and 94 Figures, ...
Breaking Medicine Technology: