Navigation Links
Neural Stem Cells Reduce Parkinsons Symptoms in Monkeys

New Haven, Conn. Primates with severe Parkinsons disease were able to walk, move, and eat better, and had diminished tremors after being injected with human neural stem cells, a research team from Yale , Harvard, the University of Colorado, and the Burnham Institute report today in Proceedings of the National Academy of Sciences.

These results are promising, but it will be years before it is known whether a similar procedure would have therapeutic value for humans, said the lead author, D. Eugene Redmond Jr., professor of psychiatry and neurosurgery at Yale.

Not only are stem cells a potential source of replacement cells, they also seem to have a whole variety of effects that normalize other abnormalities, Redmond said. The human neural stem cells implanted into the primates survived, migrated, and had a functional impact. Its an important step, but there are a number of studies that need to be done before determining if this would be of any value in clinical settings.

Parkinsons disease is caused by a degeneration of dopamine neurons in an area of the midbrain known as the substantia nigra, which is responsible for dopamine production. Reduced production of dopamine in late stage Parkinsons causes symptoms such as severe difficulty in walking, fewer movements, delays in moving, lack of appetite, difficulty eating, periods of remaining motionless known as freezing, and head and limb tremors.

In this study five of eight monkeys with advanced Parkinsons were injected with human neural stem cells and three received sham injections. The monkeys were observed four months before and four months after surgery.

Those injected with human neural stem cells improved progressively for the entire post-treatment period and were significantly different from the monkeys that received sham injections. Twenty-one additional monkeys were studied for up to eight months for other biological effects of the stem cell s. No tumors or toxic effects were found.

Redmond said a small number of the human neural stem cell progeny differentiated into neurons that contained tyrosine hydroxylase and dopamine transporter. Cell progeny containing these markers suggest that the microenvironment within and around the brain lesions still permits development of a dopamine phenotype by responsive progenitor cells. The stem cells also made a growth factor that has been shown to improve dopamine function.

The neural stem cells are derived from fetal brain and are not embryonic stem cells. Monkeys with chimeric human neural cell-bearing brain regions showed no indication of behaviors that were not typical of the species.


'"/>




Related medicine news :

1. Gamma Knife Offers New Hope For Trigeminal Neuralgia Patients
2. Botox Relieves Neuralgic Pain
3. Fetal Neural Grafts Improves Motor and Cognitive Function in Huntington Patients
4. A boon to the paralyzed -Brain Gate Neural Interface System
5. Research Reveal A New Angle On Neural Circuits.
6. Neural Basis of Anxiety: Newer Insights
7. Blood Cells Capable of Regenerating Liver
8. White Cells Count Can Predict Heart Attack Death Risk
9. Gene Therapy Destroys Pancreatic Cancer Cells
10. Stem Cells Have Few Mutations
11. Heart may pull Cells from Body to Self-repair
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California and ... pancreatic cancer. , Gary D. Radine, who recently retired as president and CEO of ... Society’s 2015 CEO of the Year , helped lead the effort to raise ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating disorders and post-traumatic stress ... women and men with eating disorders report a history of trauma, research suggests ... of an eating disorder. , At the 2016 iaedp Symposium, the workshop, ...
(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published data from ... type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels ... in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua ... on how healthcare companies can use newly released government data on populations and ... population and intervene and capture the value they create to succeed in new ...
(Date:2/8/2016)... ... February 08, 2016 , ... According to research ... U.S. require dental technicians to be certified or obtain continuing education. To increase ... the “What’s In Your Mouth?” campaign to inform dentists and patients about the ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... and FAIRFIELD, N.J. , ... and Medimetriks Pharmaceuticals, Inc. (Medimetriks) today announced that they ... development and commercialization rights for OPA-15406 in the U.S. ... also provides manufacturing rights.  OPA-15406 is a topical, non-steroidal ... atopic dermatitis. --> --> ...
(Date:2/8/2016)... -- --> --> ... Market by Product (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, Microwave) ... Gynecology) - Global Forecasts to 2020", published by MarketsandMarkets, ... period of 2015 to 2020. The market is expected ... 10.5% from 2015 to 2020. Browse 73 ...
(Date:2/8/2016)... , Feb. 8, 2016 In a historic vote among its ... to construct a medical cannabis cultivation facility and dispensary on tribal land ... New York as a provider for patients in the state,s ... as a provider for patients in the state,s Medical Cannabis ... (34) to approve the project and pursue designation from the ...
Breaking Medicine Technology: