Navigation Links
Naturally Occurring Enzyme Can Break Down Key Part of Alzheimer's Plaques

Scientists have identified a naturally occurring enzyme that can break down a key component of the brain plaques characteristic of Alzheimer's disease.// The finding may provide researchers with new opportunities to understand what goes wrong in the brains of Alzheimer's patients and could one day help them seek new therapies.

Researchers at Washington University School of Medicine in St. Louis showed earlier this summer that the enzyme, matrix metalloproteinase 9 (MMP-9), degrades abnormally aggregated proteins known as amyloid fibrils, a main ingredient of brain plaques. In the brain, MMP-9 is made by support cells known as astrocytes.

MMP-9 is already well-known because of its links to cancer metastases, vascular disease, arthritis and other pathologies. Scientists called the new link to Alzheimer's encouraging, noting that previously identified enzymes only degrade a smaller, nonaggregated component of Alzheimer's plaques.

"We already knew of three enzymes that break down amyloid beta (Abeta), a protein fragment that clumps together with itself to form the fibrils," says Jin-Moo Lee, M.D., Ph.D., assistant professor of neurology. "But the thinking up until now had been that Abeta might be clumping together so tightly that the fibrils were indestructible."

In a new study, appearing October 25 in The Journal of Neuroscience, Lee's group found that disabling the mouse gene for MMP-9 increased levels of Abeta in the spaces between brain cells. The finding proves that MMP-9 contributes to clearance of Abeta from extracellular spaces and suggests its dysfunction could potentially contribute to the development of Alzheimer's.

"MMP-9 and other enzymes like it are secreted from brain support cells and active in the spaces outside of cells, and that's where we saw an increase in Abeta levels in the mice that lacked the gene for MMP-9," Lee notes. "That's relevant to Alzheimer's because all the amyloid plaques are
'"/>




Page: 1 2

Related medicine news :

1. Naturally Occurring Hormone Can Lead To Miscarriage
2. Infertile Couples Should Keep Trying Naturally
3. Boosting Energy Naturally
4. Airborne Infection Less in Naturally Ventilated Rooms
5. Tumors Targeted Naturally
6. Naturally Occurring Hormone Can Lead To Miscarriage
7. Kidney Stones Occurring More Often in Children
8. Enzyme may be target for obesity drugs
9. Researchers trick Alzheimers Enzyme
10. Enzyme stimulates growth of adult stem cells
11. Enzyme may aid hold back disease
Post Your Comments:
(Date:3/30/2015)... Daily sun exposure, stressors and environmental ... wrinkles, folds and other giveaways of age. However, advances ... women to hit the pause button, delaying the impact ... tuck or hack to rejuvenate any facial feature. , ... Surgery (AAFPRS) explores the intricacies of The Aging ...
(Date:3/30/2015)... Considered to be the best assessment tool for ... community, this next generation of the IT Audit ... data and frameworks with virtually endless possibilities. These new ... logic features are a technological force to be reckoned ... “The IT Audit Machine is just one of the ...
(Date:3/30/2015)... March 30, 2015 Cutting-edge doctors and ... 2015 Conference because of the opportunities to present and ... conference will highlight parents of recovered children, who will ... Romaniec, will debut her book Victory over Autism: Practical ... Free copies of Victory over Autism will be available ...
(Date:3/30/2015)... (PRWEB) March 30, 2015 Developing new ... to the use of cellular models that recapitulate only ... entirety of the disease. , A company that ... cells to precise specifications has created iPSC-derived cardiomyocytes ... environmentally and genetically driven in vitro models of Diabetes ...
(Date:3/29/2015)... At the 2015 International Health Racquet & ... the new Fonda wall mounted heater and a continuing ... and facilities managers with saunas smaller than 425 cubic ... the Fonda heater. With an attractive seamless red ... upgrade for a sauna, especially when mounted in front ...
Breaking Medicine News(10 mins):Health News:New AAFPRS Infographic Addresses Concerns and Provides Aging Face Solutions 2Health News:Building on Success: Next Generation of Cyber Crime Prevention Unveiled! 2Health News:AutismOne and Focus for Health Highlight Victory over Autism at Major Chicago Conference Following Autism Awareness Month 2Health News:AutismOne and Focus for Health Highlight Victory over Autism at Major Chicago Conference Following Autism Awareness Month 3Health News:Cellular Dynamics’ Webinar Spotlights Diabetic Cardiomyopathy-in-a-dish Model that May Elucidate Mechanisms for Repair and Regeneration of Heart Muscle Cells 2Health News:Cellular Dynamics’ Webinar Spotlights Diabetic Cardiomyopathy-in-a-dish Model that May Elucidate Mechanisms for Repair and Regeneration of Heart Muscle Cells 3Health News:Cellular Dynamics’ Webinar Spotlights Diabetic Cardiomyopathy-in-a-dish Model that May Elucidate Mechanisms for Repair and Regeneration of Heart Muscle Cells 4Health News:Helo Commercial Introduces Fonda Sauna Heater and Sauna and Steam Continuing Education Program at IHRSA 2
... Sweden have successfully transferred a uterus into a sheep, and ... They explained that the operation proves that a womb can ... an animal. ,Tests that were conducted on the ... surgery and is continuing to function normally. It was explained ...
... been found to have a role in the treatment of ... // ,The results of the study have been ... Journal of Medicine, which has revealed that this immunosuppressive drug ... as well as the quality of life for people with ...
... forensic medicine lecturer faces disbarment from Medical Council of India (MCI) ... the same time, which is against the rules of the MCI. ... his employment with Sion Hospital. ,If he is debarred, ... has already been debarred till July 31, 2007 for an earlier ...
... to buy Swedish medical company Biacore to complement its ... announced. // ,The Fairfield, Connecticut-based GE will ... for 3.22 billion Swedish kroner ($438 million). ... percent stake in Uppsala, Sweden-based Biacore, supports the bid, ...
... to thee?' - sounds odd?,But it is a dyslexic's mode ... , The learning disability, dyslexia, has a genetic component, ... opens up ways for treatment. , Dyslexia ... Network report that they have located the dyslexia gene, denoted ...
... insisted that hospital consultants who are not referring patients to ... concerns that the NTPF has only seen a fraction of ... ,NTPF chairman Pat O'Byrne commented that there was no ... months for a surgical procedure. ,"There's no doubt ...
Cached Medicine News:Health News:Scientists Claim Human Womb Transplants Possible 2Health News:Cancer Drug to Treat Scleroderma Lung Disease 2
(Date:3/27/2015)... , March 27, 2015   Cypher ... today announced new data showing that, compared to ... technology provided highly equivalent interpretations of whether ... and did so in a fraction of the ... way for more comprehensive genetic analysis in non-invasive ...
(Date:3/27/2015)... 27, 2015 XRpro Sciences, Inc., a ... and development services which features high throughput transporter ... announced financial results for the year ended December ... Chairman of XRpro Sciences commented, "We have completed ... development stage to commercial stage in large part ...
(Date:3/27/2015)... 2015 According to a new ... (Conventional, Advanced, Ultrasound), Ablation Catheter (Cryoablation, RF, Microwave), Lab ... VT, WPW) - Global Forecasts to 2019 ", published by ... around ~$4.73 Billion by 2019 with a CAGR of ... Browse   90   ma ...
Breaking Medicine Technology:New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4Electrophysiology (EP) Market Worth $4.73 Billion by 2019 2Electrophysiology (EP) Market Worth $4.73 Billion by 2019 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 4
... Instrument announced the award of two contracts from the ... Evaluation and Research (CDER).  The first award is a ... Warehouse, and the second award supports the expansion of ... Mortara has a long-standing relationship with ...
... Sept. 30 HHS, Agency for Healthcare Research and ... grants and contracts to support projects that will help ... evidence of effectiveness. The funding announced today covers all ... HHS Secretary by AHRQ.   The projects ...
Cached Medicine Technology:Mortara Instrument Announces ECG Warehouse Contract Awards With US FDA 2HHS Awards $473 Million in Patient-Centered Outcomes Research Funding 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: