Navigation Links
Natural Approach to Immune Regulation May Help Transplant Patients

A molecule expressed during pregnancy seems to turn down the immune system, making it more tolerant of welcome visitors such as a fetus or maybe a transplanted heart//, researchers say.

Human leukocyte antigen G, or HLA-G, is a member of a gene family called major histocompatibility complex that provokes an immune response, says Dr. Anatolij Horuzsko, reproductive immunologist at the Medical College of Georgia.

Like an errant child, HLA-G instead promotes tolerance, and researchers have found it can even make other gene family members more accepting, says Dr. Horuzsko, who is presenting his research during the Fourth International Conference on HLA-G July 10-13 in Paris and chairing a session on structure and receptor interaction. His research also is featured in the August issue of the European Journal of Immunology.

The placenta expresses HLA-G from the earliest stages of embryo implantation and the molecule goes away toward the end of pregnancy. Growth factors and cytokines – signaling compounds involved in the development and function of the immune system – bring to the surface inhibitory receptors previously buried inside immune cells so they can interact with the HLA-G.

Amazingly, scientists have documented this natural immunosuppression, to a lesser extent, in at least one more situation: when an organ is transplanted. Dr. Horuzsko wants to augment this natural process so transplant patients won't require a lifetime of generalized immune suppression that puts them at risk for many other diseases.

He has created animal models in which these inhibitory receptors are expressed on the cell surface. Using the same mixture the body uses – cytokines and growth factors – he also gets the receptors expressed on the surface of human cells in a test tube. He gives HLA-G in both situations and studies the response.

In dendritic cells, major orchestrators of the immune response, he has watched how act ivated inhibitory receptors down-regulate the function of stimulators of the immune response also present on the cell surface. Interestingly, the targets are members of the major histocompatibility complex family to which HLA-G belongs.

"These dendritic cells are not defective, but they develop tolerogenic properties, which are not normal for them," says Dr. Horuzsko, who equates modifying the immune response to turning down the volume of a television. "We think we can help them into a tolerogenic pathway by giving HLA-G and get them to ignore the antigen coming from transplanted tissue," he says. Unfortunately, he notes, cancer and some viruses seem capable of similar manipulation.

Using this approach, he has been able to prolong acceptance of skin grafts, which are typically rapidly rejected, sometimes indefinitely.

He's also getting T cells, another major player in the immune response, to express inhibitory receptors. Normally dendritic cells show an invader to T cells which produce cytotoxic T cells to destroy it. But when T cells express the inhibitory receptor, they go silent and may even die.

A long list of other cells that provoke an immune response might be "kept under control" by this approach, Dr. Horuzsko says.

He envisions, in the not too distant future, giving cytokines and growth factors to patients so targeted cells will express inhibitory receptors then delivering a sort of HLA-G manufacturing plant, probably blood-derived stem cells modified to produce it. In patients who already express inhibitory receptors, it may be enough to give only HLA-G. Dr. Horuzsko plans to further investigate this expression that occurs soon after an organ transplant in some patients.

These natural approaches would be used to prepare a patient for transplant and activated when problems with rejection emerge.

"I believe this natural mechanism is a very powerful tool for protecting tissue a llografts from rejection," says Dr. Horuzsko.

(Source: Newswis)

Related medicine news :

1. Accuracy of Some Natural Family Planning Methods Questioned .
2. Natural formula for protection against vision loss
3. Naturally Occurring Hormone Can Lead To Miscarriage
4. Treating Leukemia With Natural Cells
5. Natural Sulfur Can Treat Pain From Osteoarthritis
6. Chronic Post-Traumatic Stress Disorder (PTSD) Risk In Young Natural Disaster Survivors
7. Tsunami Unplugged: Natural Disasters Favor the Under-privileged
8. ‘Natural Spring’ Starts A Week Ahead Now Than Before: UNH Scientit
9. An After-Dinner Nap Is A Natural Thing, Scientists Proved
10. The Most Natural Thing in the World
11. Fertility Technique only as Effective as the Natural Way
Post Your Comments:

(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: