Navigation Links
Nasal Spray Could Take Drugs Direct to Brain.

Delivering drugs via nasal spray might overcome a major obstacle to treating brain ailments such as strokes according to researchers.

Based on early studies in rats, researchers from the Stroke Lab and Alzheimer's Research Center in St. Paul, Minnesota, reported that “a direct path from the nose to the brain” could breach the blood-brain barrier, which protects the brain from foreign substances, including drugs.

Senior investigator Dr. William H. Frey II said that his team used a nasal spray to deliver insulin-like growth factor-1, a natural substance that has been shown to protect rat brains from stroke, to tissue deep inside rat brains.

In an interview, Frey said this finding is significant because researchers think this same substance may protect human brains from the devastating effects of stroke, but no one has been able to figure out a way to deliver the drug.

“It stops at the blood-brain barrier,” Frey said. “The only way to get it to the brain would be by drilling a hole in the skull and putting the drug in that way. Not a very practical approach.”

The nasal spray allows the drug to travel to the brain along “neural pathways directly to the brain,” he said. For example, the olfactory system--the sense of smell--has nerve endings “that reach down to the nose.” The drug travels along those pathways directly to the brain, he said. This method, according to Frey, means the drug reaches the brain much faster than it would if it were administered into a vein.

In this study, Frey and colleagues administered the growth factor to 37 male rats in which the researchers induced brain damage that mimics strokes in human brains. They then tested various motor and sensory reflexes to determine if the rats' symptoms were decreased, indicating that the drug had reached its target.

The test results indic ated that the drug had “been successfully diffused in brain tissue,” Frey said. Asked about the implications of Frey's work, Dr. Philip Gorelick, director of the Center for Stroke Research, Chicago, Illinois, said the study was very preliminary but said that it was an intriguing notion. Gorelick pointed out that one of the more daunting aspects of brain research is overcoming the blood brain barrier.

“This might be an option,” Gorelick said, but he noted what works in arat often fails in humans.


Related medicine news :

1. Nasal Spray Could Take Drugs Directly to Brain
2. Nasal Spray Beats Antihistamine
3. Nasal sprays used for other ailments!
4. Chronic Sinusitis May Be Related To Nasal Mucus
5. Stress – Buster : Hormonal Nasal Spra
6. Cluster Headaches Can Be Treated By Nasal Spray
7. Nasal Plastic Surgery Improves Airway Function
8. Compellis Pharmaceuticals Gets Patent for Obesity-Fighting Nasal Spray CP404
9. Patients Dissatisfied Following Closed Reduction Of Nasal Fractures
10. Nasal Spray Could Take Drugs Directly to Brain
11. Nasal Spray Beats Antihistamine
Post Your Comments:

(Date:11/29/2015)... ... , ... While conventional walkers afford considerable help with mobility, their design does ... an inventor from Uniontown, Pa., has found a way to address those needs. , ... standard walker to improve the user’s quality of life. To begin with, this improved ...
(Date:11/29/2015)... San Jose, CA (PRWEB) , ... November 29, 2015 , ... ... Bay Area, is proud to announce their December, 2015, featured apartment community: Epic. In ... looking for corporate housing in the tight Bay Area rental market to efficiently find ...
(Date:11/28/2015)... ... , ... Beginning November 30th at 6:00 a.m. EST until 11:59 p.m. EST, ... of up to 20% off orders $80 or more to free gifts with purchases, there ... , As a competitive e-commerce website for skin care and cosmetic needs, customers will save ...
(Date:11/27/2015)... ... 2015 , ... According to an article published November 6th by ... University of British Columbia suggested that laws requiring bicyclists to wear helmets may not ... of the reason for the controversial conclusion is that, while helmets have certainly prevented ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... a safe and convenient way to dispense prescription medications at home, so he ... effective way to monitor and dispense prescription medications. In doing so, it could ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
(Date:11/26/2015)... PUNE, India , November 26, ... --> --> ... Research Report" and "Investigation Report on ... 2019 and 2021 forecasts data and ... library. . ...
(Date:11/25/2015)... 25, 2015 ... the "Global Brain Monitoring Devices Market ... --> ) has announced the ... Devices Market 2015-2019" report to their ... ( ) has announced the addition ...
Breaking Medicine Technology: