Navigation Links
Nasal Spray Could Take Drugs Direct to Brain.

Delivering drugs via nasal spray might overcome a major obstacle to treating brain ailments such as strokes according to researchers.

Based on early studies in rats, researchers from the Stroke Lab and Alzheimer's Research Center in St. Paul, Minnesota, reported that “a direct path from the nose to the brain” could breach the blood-brain barrier, which protects the brain from foreign substances, including drugs.

Senior investigator Dr. William H. Frey II said that his team used a nasal spray to deliver insulin-like growth factor-1, a natural substance that has been shown to protect rat brains from stroke, to tissue deep inside rat brains.

In an interview, Frey said this finding is significant because researchers think this same substance may protect human brains from the devastating effects of stroke, but no one has been able to figure out a way to deliver the drug.

“It stops at the blood-brain barrier,” Frey said. “The only way to get it to the brain would be by drilling a hole in the skull and putting the drug in that way. Not a very practical approach.”

The nasal spray allows the drug to travel to the brain along “neural pathways directly to the brain,” he said. For example, the olfactory system--the sense of smell--has nerve endings “that reach down to the nose.” The drug travels along those pathways directly to the brain, he said. This method, according to Frey, means the drug reaches the brain much faster than it would if it were administered into a vein.

In this study, Frey and colleagues administered the growth factor to 37 male rats in which the researchers induced brain damage that mimics strokes in human brains. They then tested various motor and sensory reflexes to determine if the rats' symptoms were decreased, indicating that the drug had reached its target.

The test results indic ated that the drug had “been successfully diffused in brain tissue,” Frey said. Asked about the implications of Frey's work, Dr. Philip Gorelick, director of the Center for Stroke Research, Chicago, Illinois, said the study was very preliminary but said that it was an intriguing notion. Gorelick pointed out that one of the more daunting aspects of brain research is overcoming the blood brain barrier.

“This might be an option,” Gorelick said, but he noted what works in arat often fails in humans.


'"/>




Related medicine news :

1. Nasal Spray Could Take Drugs Directly to Brain
2. Nasal Spray Beats Antihistamine
3. Nasal sprays used for other ailments!
4. Chronic Sinusitis May Be Related To Nasal Mucus
5. Stress – Buster : Hormonal Nasal Spra
6. Cluster Headaches Can Be Treated By Nasal Spray
7. Nasal Plastic Surgery Improves Airway Function
8. Compellis Pharmaceuticals Gets Patent for Obesity-Fighting Nasal Spray CP404
9. Patients Dissatisfied Following Closed Reduction Of Nasal Fractures
10. Nasal Spray Could Take Drugs Directly to Brain
11. Nasal Spray Beats Antihistamine
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2020)... ... January 12, 2020 , ... Cecelia Health ... York City, has continually innovated for over a decade to transform lives and ... device companies and self-insured employers. By optimizing the mix of expert clinician and ...
(Date:1/10/2020)... ... January 10, 2020 , ... Ziegler, a specialty investment bank, ... Ltd. on its partnership with US Radiology Specialists (“USRS”), backed by private equity ... is the largest private practice radiology group and outpatient imaging operator in Tucson, ...
(Date:1/10/2020)... ... January 10, 2020 , ... The value of healthy vision ... via a preventative approach. Leading eye care doctor, Brent Bellotte MD., champions such proactive ... common eye diseases. , Eyesight is something that many take for granted until a ...
(Date:1/10/2020)... ... January 10, 2020 , ... The Board of ... Emergency Nurse (CPEN) specialty nursing certification program has been reaccredited by the ... national board certification earned by registered nurses (RNs) who demonstrate advanced knowledge ...
(Date:1/8/2020)... ... January 08, 2020 , ... Mirror Mirror Beauty ... 2019 Best of Memorial Readers’ Choice Awards. Located adjacent to Vitenas Cosmetic ... MedSpa in Memorial reflects Mirror Mirror Beauty Boutique’s commitment to the hottest noninvasive ...
Breaking Medicine News(10 mins):
(Date:1/3/2020)... ... January 03, 2020 , ... In Partnership with the Smiles for ... underinsured individuals at its Burleson, TX office on February 8th. , Dental services provided ... cleanings and extractions . For more information, please visit the Monarch ...
(Date:1/3/2020)... (PRWEB) , ... January 03, 2020 , ... ... division by Montreal-based AlayaCare. The combined business will offer enterprise solutions for ... acquire all Procura assets, people and customer contracts and will move forward under ...
(Date:1/2/2020)... ... January 02, 2020 , ... ... address all levels of psychiatric-mental health nursing administration, education, practice, and research. ... 1800+ registered and advanced practice nurses. Nurses from varied backgrounds are encouraged ...
Breaking Medicine Technology: