Navigation Links
Nanotechnology – to detect and treat ovarian cance

Manufacture of stain resistant clothes to light and strong tennis rackets…. The way things are created is being transformed by nanotechnology. But, this technology will// have its greatest influence on the healthcare industry in future.

Researchers at Rush University Medical Center in Chicago think that remarkably new ways of diagnosing and treating ovarian cancer can be developed using nanotechnology. Rush researchers are using state-of-the-art nanotechnology to improve women’s health. They are working in collaboration with Argonne National Laboratory and the Illinois Institute of Technology.

"While the mortality rates of many cancers have decreased significantly in recent decades, the rate for ovarian cancer had not changed much in the last 50 years, primarily due to delays in diagnosis," said Dr. Jacob Rotmensch, section director of gynecologic oncology at Rush. "By exploiting the unique properties of nanotechnology, we hope to detect ovarian cancer earlier using highly sensitive imaging tools and develop drug carriers that can deliver therapeutic agents inside tumor cells."

"A nanotechnology based approach is needed because diagnosis of early stage cancer requires the detection and characterization of very small quantities of biomarker," added Dr. Liaohai Chen, a molecular biologist and leader of the nano-bio group in the Biosciences Division at Argonne, and an adjunct faculty at Rush University Medical Center.

A nanometer is one billionth of a meter or 1/80,000 the width of a human hair. Nanoscale devices can perform tasks inside the body that would otherwise not be possible, such as entering most cells and moving through the walls of blood vessels. As a result, nanoscale devices can readily interact with individual molecules on both the cell surface and within the cell, in ways that do not alter the behavior of those molecules.

One area of research involves developing a screening test that would not require re moval of the ovary for biopsy. Collaborating with Dr. Rong Wang, an associate professor at Illinois Institute of Technology, the research team is using an atomic force microscope, a very-high resolution microscope that can investigate the interaction of individual protein molecules. With this microscope the research team can study the molecular structure of cancer versus non-cancer cells and compare the stiffness. Cancer tissues are more stiff than healthy tissues. Instead of removing the ovary to determine if cancerous tissue is present, a probe is currently under development to follow the tissue stiffness in vivo to diagnose cancer.

A second area of research involving nanotechnology uses viral particles as templates to fabricate uniform, nanometer imaging probes and drug carriers. The research team is extracting the DNA from viral particles and replacing it with imaging agents. The goal is to have the viral capsule adhere to a cancer cell and inject the imaging or a therapeutic agent into the cell. This technology could lead to early diagnosis and the development of targeted drug therapy that kills cancer cells while leaving the rest of the body unharmed.

"The development of a smart probe and carrier complex will provide significant advantage to the clinicians as they can locate the tumor, monitor the drug delivery vehicle and control drug release using imaging techniques," said Chen.

Another avenue of nanotechnology research at Rush is to develop nanometer sized contrast agents with ultrasound to diagnose ovarian cancer. Such nano ultrasonographic contrast media can pass through the smallest capillaries. These tiny bubbles light up on ultrasound and may be able to show the earliest vascular changes associated with ovarian malignancy. If this is successful, further research will be conducted to study targeted imaging as well as targeted therapy.

Ovarian cancer is the fifth-most common cancer among American women and claims t he lives of more North American women each year than all other gynecologic malignancies combined. About 75 percent of patients are not diagnosed until the disease is in its later stages, and current therapies are not effective enough to successfully treat the disease in such advanced stages.

"There has been a great amount of progress made in the field of nanotechnology over the last five years, but it has not yet been applied to women's health," said Rotmensch. "We believe this 'small-particle' technology has the capability to quickly and sensitively detect cancer molecules earlier than ever before. This research opens new avenues that will directly impact patient care, such as drug development, diagnostic imaging and ultimately, prevention."

Source: Eurekalert

Related medicine news :

1. CoQ10 bioavailability increased by Nanotechnology
2. Nanotechnology Revolution To Be Spearheaded By European Union
3. RNA Nanotechnology To Rescue Cancer Patients In Future
4. Scientists Consider About New Technology Called Nanotechnology
5. Potential Benefits Of New Nanotechnology
6. Nanotechnology Promises Huge Medical Benefits
7. Nanotechnology at its best: Nanomotors And Mechanical Nanoswitches
8. Nanotechnology Could Revolutionize Cardiac Treatment
9. Anti-Sense Drugs and Nanotechnology Offer New Hope In Cancer Fight
10. Nanotechnology Used For Detecting Viruses
11. India, China Trying to Fight Disease With Nanotechnology
Post Your Comments:

(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
(Date:6/23/2016)... , June 23, 2016  The National Pharmaceutical ... joined the health policy research organization as its ... , MD, senior vice president and chief scientific ... representative on the NPC Board of Directors. ... that Mallinckrodt has joined us in support of ...
Breaking Medicine Technology: