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Nanospectrometer Aids in Identifying Nutrient Cycle

terocyst.Nealson described the study as a technology demonstration in one of the toughest systems to study in the world.

He predicted that NanoSIMS would find general applications in biology and medical research. The technology produces time-series observations of chemical composition, and doubles as an electron microscope to allow researchers to overlay chemical and physical images.

It opens up a whole world of studies, Nealson said. You can use this technology to look at things going on inside the cell. This is going to change the way that we do a lot of microbiology.

Capone added that the structural imaging capability of NanoSIMS could allow medical researchers to study metabolic function in distinct cell types, in cells at different stages of development and in cancerous versus non-cancerous cells.

Gunther Dennert, professor of molecular microbiology at the USC Keck School of Medicine, said he could see many interesting questions, which could perhaps be attacked experimentally by this technique.

For example, how do tissues react upon implantation of a metastasizing tumor cell, and what does the tumor cell synthesize in order to make implantation possible

For examples of current cancer research using NanoSIMS, see http: www.llnl.gov/str/JulAug03/Hartmann-Siantar.html or http: www.llnl.gov/str/JulAug03/Wyrobek.html.


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