Navigation Links
Nanospectrometer Aids in Identifying Nutrient Cycle

Scientists at the University of Southern California have applied a nanoscale imaging method to a biological system, helping to clear up an old puzzle of the global carbon and nitrogen cycle . Their study appears as an advanced online publication of The ISME Journal.

A state of the art NanoSIMS instrument (short for nanometer-scale, secondary ion mass spectrometry) located at Lawrence Livermore National Laboratory can image and measure minute amounts of chemical elements.

Douglas Capone and Kenneth Nealson, USC Wrigley Professors of Environmental Biology and Geology, respectively, used NanoSIMS to track the flow of carbon and nitrogen inside two types of cells in the freshwater organism Anabaena oscillarioides.

This instrument is allowing us to look at how these two elements are being taken up and are being transported around these different types of cells, Capone said. Its basically allowing us to image elements at very high resolution.

The organism fixes, or pulls from the atmosphere, both carbon and nitrogen. For decades biologists wondered how the organism could fix both elements, since carbon fixation associated with photosynthesis produces oxygen, while nitrogen fixing needs an oxygen-free environment.

Previous studies have shown that some photosynthetic cells can differentiate into heterocysts: thick-walled relatives that fix nitrogen but do not produce oxygen.

Using NanoSIMS, Capone and Nealson followed nitrogen as it is fixed in heterocysts and then transported to the other cells, where it is needed as a nutrient.

Capone and Nealson also were able to observe cellular differentiation: as the single-stranded organism grows, the nitrogen concentration in the cell halfway between two existing heterocysts falls below a threshold. Its basically allowing us to image elements at very high resolution.

The drop in nitrogen starts a process that turns the cell into a he terocyst.Nealson described the study as a technology demonstration in one of the toughest systems to study in the world.

He predicted that NanoSIMS would find general applications in biology and medical research. The technology produces time-series observations of chemical composition, and doubles as an electron microscope to allow researchers to overlay chemical and physical images.

It opens up a whole world of studies, Nealson said. You can use this technology to look at things going on inside the cell. This is going to change the way that we do a lot of microbiology.

Capone added that the structural imaging capability of NanoSIMS could allow medical researchers to study metabolic function in distinct cell types, in cells at different stages of development and in cancerous versus non-cancerous cells.

Gunther Dennert, professor of molecular microbiology at the USC Keck School of Medicine, said he could see many interesting questions, which could perhaps be attacked experimentally by this technique.

For example, how do tissues react upon implantation of a metastasizing tumor cell, and what does the tumor cell synthesize in order to make implantation possible

For examples of current cancer research using NanoSIMS, see http: www.llnl.gov/str/JulAug03/Hartmann-Siantar.html or http: www.llnl.gov/str/JulAug03/Wyrobek.html.


'"/>




Related medicine news :

1. Identifying bacteria made amiable
2. Identifying brain lesions with impaired consciousness
3. Identifying Virus Found To Be Essential for HIV Patients
4. Identifying Those At Risk For Diabetes
5. Identifying Predictors Of Anthrax
6. Identifying The Risks Of Developing Schizophrenia
7. Identifying Irregular Heart Beats
8. Identifying Those At Risk For Diabetes
9. Identifying Heart Disease Early
10. Identifying The Risk For Kidney Infection
11. Identifying What Consumers Look For On Food Stuff Labels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... ... 12, 2017 , ... Dr. Parsa Mohebi, the Los Angeles ... to the newly revamped Cosmetic Town journal section, featuring articles written ... known as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:10/2/2017)... 2, 2017 Halo Labs announces the European launch of ... the HORIZON at MIBio 2017 in Cambridge, U.K ... particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity while ... technique Backgrounded Membrane Imaging. ... HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: