Navigation Links
Nanospectrometer Aids in Identifying Nutrient Cycle

Scientists at the University of Southern California have applied a nanoscale imaging method to a biological system, helping to clear up an old puzzle of the global carbon and nitrogen cycle . Their study appears as an advanced online publication of The ISME Journal.

A state of the art NanoSIMS instrument (short for nanometer-scale, secondary ion mass spectrometry) located at Lawrence Livermore National Laboratory can image and measure minute amounts of chemical elements.

Douglas Capone and Kenneth Nealson, USC Wrigley Professors of Environmental Biology and Geology, respectively, used NanoSIMS to track the flow of carbon and nitrogen inside two types of cells in the freshwater organism Anabaena oscillarioides.

This instrument is allowing us to look at how these two elements are being taken up and are being transported around these different types of cells, Capone said. Its basically allowing us to image elements at very high resolution.

The organism fixes, or pulls from the atmosphere, both carbon and nitrogen. For decades biologists wondered how the organism could fix both elements, since carbon fixation associated with photosynthesis produces oxygen, while nitrogen fixing needs an oxygen-free environment.

Previous studies have shown that some photosynthetic cells can differentiate into heterocysts: thick-walled relatives that fix nitrogen but do not produce oxygen.

Using NanoSIMS, Capone and Nealson followed nitrogen as it is fixed in heterocysts and then transported to the other cells, where it is needed as a nutrient.

Capone and Nealson also were able to observe cellular differentiation: as the single-stranded organism grows, the nitrogen concentration in the cell halfway between two existing heterocysts falls below a threshold. Its basically allowing us to image elements at very high resolution.

The drop in nitrogen starts a process that turns the cell into a he terocyst.Nealson described the study as a technology demonstration in one of the toughest systems to study in the world.

He predicted that NanoSIMS would find general applications in biology and medical research. The technology produces time-series observations of chemical composition, and doubles as an electron microscope to allow researchers to overlay chemical and physical images.

It opens up a whole world of studies, Nealson said. You can use this technology to look at things going on inside the cell. This is going to change the way that we do a lot of microbiology.

Capone added that the structural imaging capability of NanoSIMS could allow medical researchers to study metabolic function in distinct cell types, in cells at different stages of development and in cancerous versus non-cancerous cells.

Gunther Dennert, professor of molecular microbiology at the USC Keck School of Medicine, said he could see many interesting questions, which could perhaps be attacked experimentally by this technique.

For example, how do tissues react upon implantation of a metastasizing tumor cell, and what does the tumor cell synthesize in order to make implantation possible

For examples of current cancer research using NanoSIMS, see http: www.llnl.gov/str/JulAug03/Hartmann-Siantar.html or http: www.llnl.gov/str/JulAug03/Wyrobek.html.


'"/>




Related medicine news :

1. Identifying bacteria made amiable
2. Identifying brain lesions with impaired consciousness
3. Identifying Virus Found To Be Essential for HIV Patients
4. Identifying Those At Risk For Diabetes
5. Identifying Predictors Of Anthrax
6. Identifying The Risks Of Developing Schizophrenia
7. Identifying Irregular Heart Beats
8. Identifying Those At Risk For Diabetes
9. Identifying Heart Disease Early
10. Identifying The Risk For Kidney Infection
11. Identifying What Consumers Look For On Food Stuff Labels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... ... August 23, 2017 , ... ... Development and Sector Growth. Mr. Smith joins other recent high-profile hires including Frank ... Smith’s healthcare career began in 1993, helping physician practices and hospitals automate their ...
(Date:8/23/2017)... ... , ... Earlier this month, the Workgroup for Electronic Data Interchange (WEDI) ... efficiencies in healthcare information exchange and a trusted advisor to the U.S. Department of ... keynote addresses by Donald W. Rucker, MD, head of the Office of the National ...
(Date:8/23/2017)... ... August 23, 2017 , ... CEFEX, the Centre for ... the standards representing best practices in the retirement plan industry. The independent CEFEX ... helps to verify that NFP’s retirement division focuses on putting clients’ interests first ...
(Date:8/23/2017)... ... August 23, 2017 , ... Nightingale College continues the semiannual Give Back ... a time Nightingale College dedicates to serving and volunteering for organizations that provide indispensable ... volunteers or those that need a little extra help. , The College’s Give ...
(Date:8/23/2017)... ... August 23, 2017 , ... Cirrus Medical ... a new website, http://www.cirrusmedicalstaffing.com . The new site pairs a robust job ... healthcare professionals who are traveling on short-term assignments to healthcare facilities around the ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage ... its financial results for the second quarter ended June ... second quarter 2017 and to date: ... programs for the Company,s lead project, BL-8040: ... with BL-8040 as novel stem cell mobilization treatment for ...
(Date:8/7/2017)... Mich. , Aug. 7, 2017 Diplomat Pharmacy, ... of Joel Saban as president, effective Aug. 7, ... Urick has decided to pursue other interests and will ... "During his tenure, Paul has served us in multiple leadership ... Specialty Pharmacy in Jun. 2015 and has provided decisive, strategic ...
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, a ... active in the biopharmaceutical, nutraceutical, and aquacultural feed ... of its lead drug candidates, AGR131.  This drug ... cytokine from the blood of patients suffering from ... inflammatory bowel disease. ...
Breaking Medicine Technology: