Navigation Links
Nanoparticle in the Treatment of Glaucoma

Glaucoma is an eye disease that can cause blindness and affects millions of people worldwide. The nanoparticle can safely get past the blood-brain barrier making it an effective non-toxic tool for drug delivery, said Sudipta Seal, an engineering professor with appointments in UCFs Advanced Materials Processing and Analysis Center and the Nanoscience Technology Center.

Seal and his colleagues from North Dakota State University note in the article that while barely 1-3 percent of existing glaucoma medicines penetrate into the eye, earlier experiments with nanoparticles have shown not only high penetration rates but also little patient discomfort. The miniscule size of the nanoparticles makes them less abrasive than some of the complex polymers now used in most eye drops.

Seal and his team created a specialized cerium oxide nanoparticle and bound it with a compound that has been shown to block the activity of an enzyme (hCAII) believed to play a central role in causing glaucoma.

The disease involves abnormally high pressure of the fluid inside the eye, which, if left untreated, can result in damage to the optic nerve and vision loss. High pressure occurs, in part, because of a buildup of carbon dioxide inside the eye, and the compound blocks the enzyme that produces carbon dioxide.

Seal and a team of collaborators including Sanku Mallik, of North Dakota State University, developed the research on using nanoparticles as a delivery mechanism for the compound after supervising a student summer project at UCF. Duke University undergraduate Serge Reshetnikov spent a summer studying nanoscience on UCFs Orlando campus as part of a Research Experience for Undergraduates (REU) project funded by the National Science Foundation. Reshetnikov started looking into the possibilities of using nanoparticles as drug delivery tools. Subsequent research with his advisors led to the specific application for glaucoma.

In their paper on the research, which was also supported by the National Science Foundation, Seal and Mallik note the results are very promising and that their nanoparticle configuration offers seemingly limitless possibilities as a non-toxic drug delivery tool.




'"/>




Related medicine news :

1. Gene-Nanoparticle Gene Transfer Is Better Than Viral Vector Transfer System
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. Alzheimers Can Be Slowed Down By Gold Nanoparticles
4. Gold Nanoparticles Are Good Detectors Biological Toxins
5. Scientists To Study Effect Of Nanoparticles On Liver
6. Nanoparticles and Their Damage to Liver Cells
7. Effect of Nanoparticles on Liver
8. Use of Nanoparticles in Sunscreen under Scrutiny
9. Tiny Sphere Of Nanoparticles Can Fight Cancer
10. Hybrid Nanoparticles for Multimodal Medical Imaging
11. Nanoparticles Used by Researchers to Attack Brain Tumours
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... 19, 2017 , ... Creative messages to prevent distracted driving ... Impact Teen Drivers and California Casualty. Entries from students aged 14-22 can be ... $15,000 will be awarded for the best peer-to-peer messages sharing solutions to reckless ...
(Date:1/19/2017)... ... January 18, 2017 , ... The CHP suggests that California drivers can avoid ... slowing down and increasing the space between themselves and other vehicles, according to a ... attorney Raymond R. Hassanlou notes that, rain or shine, drivers should always incorporate safe ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Connecticut Dermatology Group ... Kim, a highly experienced and compassionate dermatologist. Dr. Kim brings an extensive background ... , “It is with considerable pleasure to welcome back Dr. Kim to the CDG ...
(Date:1/19/2017)... ... January 19, 2017 , ... Sales Focus Inc. (SFI), a ... the US market. , Over the past 20 years SFI has been recognized as ... has launched six new clients into the US market. The new clients include: ...
(Date:1/19/2017)... ... January 19, 2017 , ... Infinity® Massage Chairs announced today that Dan ... sales and marketing strategies. Grover comes with a total of 15 years experience in ... years as Executive Vice President of Direct Sales at Traeger® Wood Pellet Grills. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... January 19, 2017 According to a study ... is set to witness a CAGR of 6.5% during the forecast ... will continue to be the leading market for cryotherapy globally ... ... emphasizing on ensuring affordable and adequate supply of gas in order ...
(Date:1/19/2017)... 19, 2017 ViewRay, Inc. (Nasdaq: VRAY) announced today ... supporting research in Germany , has ... at the University Clinic Heidelberg as part of its ... Linac program will be headed by Medical Director and ... oncology at the German Cancer Research Center (DKFZ), the ...
(Date:1/19/2017)... , January 19, 2017 ... administration appears serious about reducing the FDA,s regulatory ... innovation in the medical drug industry, many of ... with new clinical trials and development of advanced ... forging ahead with recent developments include:  Moleculin Biotech, ...
Breaking Medicine Technology: