Navigation Links
Nanoparticle Uptake Zoom by Repetitive Motion

A recent research by North Carolina State University toxologists and Rice University Chemists// has highlighted the role of repetitive movements, in increasing the intake speed of nanoparticles through the skin. Vitro experiments on animal skin exposed to buckyballs formed the basis of the research. These bucky balls contained amino acids. Experiments showed that amino acid penetrated deeper and faster with the increasing degree of flexing of the skin. .

"Our results confirm that repetitive motion can speed the passage of nanoparticles through the skin," said Nancy Monteiro-Riviere, professor of investigative dermatology and toxicology at NC State. "As more nanoparticles find their way into the workplace and consumer goods, and as scientists look for innovative ways to use nanoparticles to deliver drugs into the body, it is critical that the nanoscience community identify these types of external exposure factors."

In the study, a solution of buckyball-containing amino acids was placed on small sections of pig skin. In some experiments, the skin was held still, and in others it was flexed for either an hour or an hour and a half. Measurements were taken eight hours after exposure and 24 hours after exposure.

The team found that the more the skin was flexed, the more buckyballs it took up and the deeper they penetrated. Penetration was also found to be deeper after 24 hours than after just eight.

Buckyballs, are spherical, soccer-ball-shaped molecules containing 60 carbon atoms. The buckyballs used in the study were part of an innovative molecule called Bucky amino acid, or Baa, that was created in the lab of Rice chemist Andrew Barron. Baa is a marriage of buckyballs and phenylalanine, one of the 20 essential amino acids that are the building blocks of all proteins.

"The findings were a bit surprising because the Bucky amino acids tend to form spherical clusters that are up to 12 times larger in diameter than the k nown width of intercellular gaps in the skin," said Barron, the Charles W. Duncan Jr.-Welch Professor of Chemistry, professor of materials science and associate dean for industry interactions and technology transfer. "It's not clear why flexing increases the uptake of fullerene peptides, but it will be important to further investigate these mechanisms as we study the medical potential of Bucky amino acids.


Related medicine news :

1. Gene-Nanoparticle Gene Transfer Is Better Than Viral Vector Transfer System
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. Alzheimers Can Be Slowed Down By Gold Nanoparticles
4. Gold Nanoparticles Are Good Detectors Biological Toxins
5. Scientists To Study Effect Of Nanoparticles On Liver
6. Nanoparticles and Their Damage to Liver Cells
7. Effect of Nanoparticles on Liver
8. Use of Nanoparticles in Sunscreen under Scrutiny
9. Tiny Sphere Of Nanoparticles Can Fight Cancer
10. Hybrid Nanoparticles for Multimodal Medical Imaging
11. Nanoparticles Used by Researchers to Attack Brain Tumours
Post Your Comments:

(Date:12/1/2015)... Wilmington, Delaware (PRWEB) , ... December 01, 2015 ... ... award winner at the 7th Annual 2015 Golden Bridge Business Awards under the ... is a zero capex web based sample management software that ...
(Date:12/1/2015)... ... 01, 2015 , ... The importance of volumetric breast density ... of numerous abstracts accepted for presentation here, at the 101st Annual Radiology Society ... the use of Volpara Solutions’ quantitative breast imaging software tools for providing breast ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... Health Center of Excellence (BHCOE) today announced that the organization has awarded Education ... San Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers ...
(Date:12/1/2015)... ... December 01, 2015 , ... TCS ... care management and population health arenas, is pleased to announce that VIP Care ... services, has successfully implemented the ACUITY Complete Care™ Management to back their collaborative ...
(Date:12/1/2015)... ... December 01, 2015 , ... With FCPX Overlay: Grit , users can ... customization, the possibilities are truly endless, all with a click of a mouse. Each ... flip, horizontal flip, depth of field and more, all within Final Cut Pro X. ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , December 1, 2015 ... market research report "Nucleic Acid Labeling Market by Product ... Translation, Random Primer, In Vitro Transcription, Reverse Transcription, End ... by MarketsandMarkets, The global market is expected to reach ... in 2015, growing at a CAGR of 8.65%. ...
(Date:12/1/2015)... 01, 2015 ... "Veterinary Equipment and Disposables Market by product, by ... to their offering. --> ) ... Equipment and Disposables Market by product, by Animal ... their offering. --> Research and Markets ...
(Date:12/1/2015)... 1, 2015  Today, AmerisourceBergen, a ... CareFront, a first-of-its-kind population health management program focused ... Designed to be built into existing employer benefit ... resources for their care and explains how to ... tools to help patients understand their treatment options ...
Breaking Medicine Technology: