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NSAIDs In First trimester Linked To Congenital Anomalies In Babies

l closure and related abnormalities.

For each infant diagnosed with a congenital abnormality, the researchers matched up to ten controls by date of conception and maternal age, region of residence, and diabetes status. They performed statistical analyses to uncover any associations between the congenital abnormalities and the mother's use of NSAIDs during the first trimester.

Among the 1056 women who filled a prescription for NSAIDs early in their pregnancy, 8.8 percent had babies with congenital anomalies. Of the 35,331 women who did not fill prescriptions for NSAIDs, 7 percent had congenital anomalies. The difference was more pronounced for cardiac septal abnormalities. Furthermore, the proportion of infants with multiple congenital anomalies among mothers who filled an NSAID prescription in the first trimester and those who did not was 16.1 percent vs. 14.2 percent respectively.

"Our analysis of data from the Medication and Pregnancy registry suggests that women who fill prescriptions for NSAIDs in the first trimester of pregnancy may be at greater risk of having children with congenital anomalies, particularly those related to cardiac septal closure," the authors conclude. "This is in accordance with previous findings, but needs to be replicated in other study populations."

(Source: EurekAlert)
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