Navigation Links
NRI Scientists find Potential Colon Cancer Weapon

A five-member team of India-born medical researchers in the United States has discovered what may become a potent new weapon in the fight against colon cancer.//

The scientists from the University of Texas succeeded in stopping colon cancer growth in mice by halting the activity of a single enzyme called aldose reductase.

Blocking this enzyme shuts down the toxic network of biochemical signals that promotes inflammation and colon cancer cell growth, the scientists reported in the latest issue of journal Cancer Research.

They showed that blocking the production of aldose reductase halts the growth of human colon cancer cells implanted in laboratory mice.

"By inhibiting aldose reductase we were able to completely stop the further growth of colorectal cancer tumour cells," they said. Colon cancer is the second leading cancer killer in the US.

The team included senior author Satish Srivastava and his colleagues - Ravinder Tammali, Kota V. Ramana, Sharad S. Singhal and Sanjay Awasthi.

In their experiments on mice, the researchers implanted human colon cancer cells beneath the skin of "nude mice" - a hairless and immune-deficient variety commonly used in medical research.

Tumour progression stopped completely in the mice treated with genetic material known as small interfering RNA (or "siRNA") that was engineered to prevent cells from making the aldose reductase enzyme.

The treated mice seemed unharmed by the procedure. In contrast, the untreated control animals experienced uncontrolled tumour growth, they reported.

The researchers, however, point out that the gap between a brand new procedure that works in nude mice and one that works in humans is considerable.

Source-IANS
'"/>




Page: 1

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/26/2017)... ... September 26, 2017 , ... Atmosera ... Release Management as a Service (RMaaS) to automate the deployment of ... include any companies, e-tailers, and web development agencies who want to improve time-to-revenue ...
(Date:9/26/2017)... ... September 26, 2017 , ... Two ... only entirely new and different, it is scientifically proven as well: ABAlife™. Euromed ... has received an exclusive license agreement with BioTherapeutics Inc. for patented technology for ...
(Date:9/26/2017)... ... 26, 2017 , ... After a summer-long contest to crown ... Designated Drivers proudly announced the winners of the HEROtini Mocktail Challenge at the ... on the challenge of competing in three categories: Best HEROtini Mocktail, Top HEROtini ...
(Date:9/26/2017)... Falls Church, VA (PRWEB) , ... September 26, 2017 , ... ... FDAnews and Cerulean Associates LLC **, Dec. 5-6, 2017 – Arlington, VA, http://www.fdanews.com/fdadataintegrity ... its investigators: “If initial findings indicate the firm’s electronic records may not be trustworthy ...
(Date:9/26/2017)... Scotch Plains, NJ (PRWEB) , ... September 26, ... ... Surgery Fellowship trained orthopedic surgeon and the Chair of the Leg, Ankle, and ... Dr. Kovatis is currently the only fellowship trained orthopedic surgeon at Hackensack UMC ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017  Medical professionals ... and skills while treating their patients. Medical ... experience without involving patients. Simulation provides a ... can carry out procedures, refine techniques and ... Integration of new technology, such as augmented ...
(Date:9/5/2017)... Colo. , Sept. 5, 2017 Sapheneia ... XR-29 DoseCheck solution. Scannerside DoseCheck is a third-party Vendor ... existing CT scanners and allows compliance with current MITA ... Sapheneia-Scannerside proprietary XR 29 DoseCheck solution is specifically designed ... and alerts of potential radiation doses over a predefined ...
(Date:9/5/2017)... Pharmaceuticals Inc. (NASDAQ: ORMP ) (TASE: ORMP) ... the development of oral drug delivery systems, announced today ... U.S. Food and Drug Administration (FDA) regarding ORMD-0801, the ... At the meeting, the FDA gave clear ... would be a Biologics License Application (BLA).  Such a ...
Breaking Medicine Technology: