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NOMID Symptoms Helped By Arthritis Drug

, had improved, and by six months, 33 percent of the patients showed improved hearing and another half of the patients had no further hearing loss from baseline. Other confirmed benefits of treatment included disappearance or lessening of headaches, reduction of central nervous system lesions, ability to lower corticosteroid doses, and remission of inflammation in more than half of patients by month six. At month three, disease flared in 11 patients when they were withdrawn from anakinra as part of the study, but when anakinra was restarted, the disease quickly responded again. Daily injections would be required for any long-term treatment.

'This study demonstrates the efficacy of anakinra in improving major organ manifestations and helps confirm the role of IL-1beta (IL-1?) in many features of the disease; most importantly, the central nervous system,' says Dr. Goldbach-Mansky.

Because NOMID is a rare disease (400 to 600 children in the United States), the study was necessarily small and lacked a control group, but the study was strengthened by the magnitude of the clinical response to the agent and the fact that the disease flared when anakinra was temporarily stopped, she says.

'NOMID is a devastating disease for which previously there was little understanding or effective treatment,' says NIAMS Director Stephen I. Katz, M.D., Ph.D. 'This study not only provides hope — in the way of an already-available agent — but it also provides a better understanding of the mechanism of the disease's damaging effects.'

Furthermore, notes Goldbach-Mansky, anakinra was safe in this clinical investigation. Unlike some other treatments used for NOMID, it caused no serious side effects in any of the patients during the study.

Source: Eureklert
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