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NOMID Symptoms Helped By Arthritis Drug

Neonatal-onset multisystem inflammatory disease (NOMID) is a rare condition that affects children as well as adults. A new study finds that a drug named anakinra could alleviate// symptoms and bring down the inflammation associated with the disease. The study is published in the August 10 issue of the New England Journal of Medicine. It was undertaken by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

NOMID, also known as chronic infantile neurologic cutaneous articular (CINCA) syndrome, is an inflammatory disorder that affects numerous organs and body systems, including the skin, joints, eyes and central nervous system. For most children, the first sign of the disease is a rash that develops within the first six weeks of life. Other problems, including fever, meningitis, joint damage, vision and hearing loss, and mental retardation, can follow. NOMID is one of a group of illnesses that NIAMS Clinical Director Daniel Kastner M.D., Ph.D. has designated autoinflammatory diseases, because of their seemingly unprovoked episodes of inflammation. Despite treatment to control the inflammation — including high-dose corticosteroids, disease-modifying antirheumatic drugs such as methotrexate, and nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen — the disease is progressive and often fatal. As many as 20 percent of children with NOMID don't survive to adulthood.

'This research shows the importance of studying rare but enormously instructive diseases, a unique strength of the NIH intramural science program,' says NIH Director Elias A. Zerhouni, M.D. 'This study provides new insights on fundamental mechanisms of inflammation. More importantly this new therapy will reduce the pain and suffering of these young patients allowing them to live a fuller life than previously possible.'

While the mechanism of NOMID is not completely understood, research in recent y
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