Navigation Links
NO Linked With Increased Survival in ALI/ARDS

Researchers, in a large-scale, multi-center trial of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), showed that higher levels of// nitric oxide (NO) in patient urine were strongly associated with improved survival. It also showed more ventilator-free days, and decreased rates of organ failure in ALI/ARDS patients.

The results appear in the first issue for February 2007 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Michael Matthay, M.D., of the University of California, San Francisco, and five associates measured NO in the urine of 566 patients enrolled in the National Heart, Lung, and Blood Institute's Acute Respiratory Distress Syndrome Network trial, which was designed to look at several different levels of respiratory support.

In humans, NO is involved in oxygen transport to the tissues, the transmission of nerve impulses and a variety of other physiological processes. A product of cellular metabolism, NO serves as a crucial physiologic messenger molecule.

ARDS is the rapid onset of respiratory failure--the inability to adequately oxygenate the blood–that often occurs in the critically ill. ALI precedes ARDS as severe respiratory illnesses progress. Both conditions can be life-threatening.

Among participants, the problems that led to ALI involved aspiration, pneumonia, sepsis (from which 25 percent suffered), and other serious medical difficulties.

The average age of the subjects was 52, with 57 percent being male and 74 percent classified as white.

By the third day of the three-day study, 62 ALI/ARDS patients had died. All of the remaining survivors had significantly higher NO levels. Lower tidal volume respiration was associated with higher levels of urine NO and fewer deaths.

The authors speculated that NO has a beneficial effect on ALI since it scavenges oxygen free radicals that are generated during oxidative stress. Since NO increases microcirculation, it helps to better perfuse tissue beds in the lungs.

The investigators offered an alternative hypothesis to explain their findings: NO created inside the body may have a beneficial effect on organs other than the lung during ALI. It might help prevent further tissue damage by improving oxygen and nutrient delivery to the tissues, while helping to decrease the amount of toxic oxygen species. The authors also speculated that NO might have antibacterial effects that could be important in infectious conditions that predispose patients to ALI.

Dr. Matthay noted that results from animal models of ALI used in prior studies could differ significantly from those associated with human physiology. He added that prior studies had been performed with a smaller number of patients associated with a single research center.

The researchers concluded that they have provided a "reasonable reflection of whole-body NO levels compared with a single organ measurement, which could have been obtained by measuring bronchoalveolar lavage fluid from the lung."


Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Cough Syrup Ingredient Linked to Stroke
3. Irregular Periods Linked to Diabetes
4. Hormones Linked To Migraines
5. Triglycerides Linked To Stroke Risk
6. Smoking Linked To Low Infant Birth Weight
7. Nausea Linked To Anxiety And Depression
8. Painkiller Linked to Deaths
9. High Levels of Protein Linked to Brain Shrinkage
10. Snoring Linked To Headaches
11. Hormone Therapy Linked to Dementia
Post Your Comments:

(Date:12/1/2015)... , ... December 01, 2015 , ... According to an ... groups has filed a discrimination claim against the U.S. Department of Health and Human ... Affordable Care Act (ACA) plans are breaking the clause in the law prohibiting the ...
(Date:12/1/2015)... ... December 01, 2015 , ... Califia Farms , one ... its iconic bottle has won top honors in Beverage World Magazine’s Global Packaging Design ... announced that it has been selected as a 2015 U.S.A. Taste Champion in the ...
(Date:12/1/2015)... ... , ... Growth in medical payments per workers’ compensation claim in Louisiana slowed ... nonhospital care, according to a recent study by the Workers Compensation Research Institute (WCRI). ... medical payments per claim with more than seven days of lost time continued to ...
(Date:12/1/2015)... ... December 01, 2015 , ... CloudLIMS today announced ... Bridge Business Awards under the New Products and Services category for its innovative ... sample management software that helps labs organize data and track samples with ...
(Date:12/1/2015)... ... December 01, 2015 , ... Diabetic foot wounds ... Podiatrists are well aware that psychology-based patient non-compliance (disobedience of a health care ... to diseases of the diabetic foot. The American Board of Multiple Specialties ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 1, 2015 --> ... report "Nucleic Acid Labeling Market by Product (Reagents & ... Primer, In Vitro Transcription, Reverse Transcription, End Labeling), by ... The global market is expected to reach USD 1,925.7 ... growing at a CAGR of 8.65%. Browse ...
(Date:12/1/2015)... Russia has always been a country of choice for ... Europe in 2015 were tested in phase II-III ... has always been a country of choice for global multi-center phase ... in 2015 were tested in phase II-III clinical trials ... always been a country of choice for global multi-center phase III clinical ...
(Date:12/1/2015)... Dec. 1, 2015 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... chronic pain, announced today that the company will present at ... December 1-3 at the Luxe Sunset Boulevard Hotel in ... CEO of Relmada Therapeutics, will present on Thursday, December 3, ... . Please register at least 10 minutes prior ...
Breaking Medicine Technology: