Navigation Links
Mutation connected to Osteoporosis

Researchers report they have identified a genetic defect that causes a rare bone disease in which the body makes too much bone, a finding that may lead to treatments for osteoporosis. According to Dr. Michael Levyn, director of the bone and mineral center at Hopkins University, the new finding will help bone researchers understand why the body loses the ability to make new bone cells as people age.//

Later, Levine explained the researchers studied DNA from 15 people who have a condition called progressive osseous heteroplasia or POH. People who have POH form extraskeletal bone, essentially small rice-like bone fragments that grow in various organs in the body. He said DNA from the patients revealed 13 of the 18 shared a GNAS1 mutation -- guanine nucleotide binding protein alpha stimulating activity polypeptide. GNAS1 controls a protein that plays a critical role in way cells function. In the case of POH, the GNAS1 mutation results in a mistaken signal to non-skeletal cells, which results in the creation of bone by the misinformed cells.

Levyn, who also worked with researchers from the University of Pennsylvania School of Medicine, the Royal Children's Hospital in Melbourne, Australia, and the Washington University School of Medicine in St. Louis, said the finding may lead to development of a genetic treatment for POH. But he said the real significance of the research might be the light it sheds on the genetic basis for bone formation. Although about one in 100,000 people have POH, many millions of people will develop osteoporosis, which affects most elderly women and many elderly men.

Up until age 30 healthy people have the ability to grow new bone but after that time the bone building cells, called osteoblasts die off and with those cells goes the ability to make bone. As the mineral content of bone decreases, the bones become fragile and easily break, which leads to the disability associated with osteoporosis.

Currently, osteop
'"/>




Page: 1 2

Related medicine news :

1. Stem Cells Have Few Mutations
2. Gene Mutation Causes Ovarian Failure
3. Mutations in NOTCH1 cause an early developmental defect in the aortic valve
4. A Word Of Caution: Routine Screening For Breast Cancer Mutation Not Advisdable
5. Coffee Reduces Risk of Breast Cancer in BRCA1 Mutation Carriers
6. CCR5 Mutation Confers Immunity Against HIV But Not Against West Nile Virus Illness
7. Wound Healing Accelerated By Mutation In Deafness Gene
8. No Mutation Of Bird Flu Virus: WHO
9. Gene Mutation May Influence Age at Onset of Parkinsons Disease
10. Menin Gene Mutation made Insulin Secreting Cells to Proliferate
11. Developing Countries Undertake Cataloguing of Human Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutation connected Osteoporosis

(Date:1/22/2015)... New York (PRWEB) January 22, 2015 ... after Fresenius Medical Care recalled its GranuFlo and NaturaLyte ... multidistrict litigation underway in U.S. District Court, District of ... dated January 20th, the Court has remanded a case ...
(Date:1/22/2015)... 22, 2015 Carinsurancesavings.biz has released a new ... and dismemberment insurance . , Purchasing an accidental death ... very advantageous. This type of rider provides benefits if the ... be considered a lesser form of life insurance. , ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Four years since the ... – which coincided with the marriage of Avasa & Matthew Love ... ROAD, which is scheduled for release through White Swan Records on ... that there is a sacred path available to all of us ...
(Date:1/22/2015)... January 22, 2015 As interest in the ... care gains momentum worldwide, Rev. Eric J. Hall , ... Network (HCCN), will be the keynote speaker on January ... Israel’s public health system. , The conference, “Hope and Resilience: ...
Breaking Medicine News(10 mins):Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3
... Tim Kaine released the following statement: , ... , , ... ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080519/DNCLOGO ) , ...
... ... Innovative Social Media and Online Communications Program , ... (PRWEB) March 22, 2010 -- The Society for New ... tank focused on the latest developments in media and communications, today announced that it ...
... , ... begins with new cast members and a new diet firmly in place. The 10th season of ... which will be providing meals daily to each cast member & dancer. , ... Los Angeles, CA (PRWEB) March 22, 2010 -- A new season of Dancing ...
... ... with nationally-recognized orthopedic hospital. , ... Oklahoma City, OK (PRWEB) March 17, 2010 -- Cornerstone Healthcare Partners has ... for the Tower Day Surgery Center and the Orthopedic Hospital, effective January 1, ...
... ,, WASHINGTON , . March 21 Health care reform is on its way and here to stay – but the work toward building a health care system that serves ... ... ... ...
... ... ... , ... ...
Cached Medicine News:Health News:DNC Chairman Tim Kaine Praises Historic Passage of Health Insurance Reform 2Health News:DNC Chairman Tim Kaine Praises Historic Passage of Health Insurance Reform 3Health News:Society for New Communications Research Receives Grant to Help Raise Awareness and Reduce Racial and Ethnic Health Disparities 2Health News:Society for New Communications Research Receives Grant to Help Raise Awareness and Reduce Racial and Ethnic Health Disparities 3Health News:Society for New Communications Research Receives Grant to Help Raise Awareness and Reduce Racial and Ethnic Health Disparities 4Health News:The Fresh Diet Dances With The Stars Keeping the Cast in Shape and on Its Toes 2Health News:Cornerstone Health Corporation Named Manager of Orthopedic Institute's Hospital and Tower Day Surgery Center 2Health News:'A Small Step For Today. A Giant Step For Tomorrow' 2Health News:'A Small Step For Today. A Giant Step For Tomorrow' 3Health News:Concord Coalition Reacts To Health Care Bill Passage: Cost Control Vigilance is Now Crucial 2Health News:Concord Coalition Reacts To Health Care Bill Passage: Cost Control Vigilance is Now Crucial 3
(Date:1/22/2015)... Calif. , Jan. 22, 2015  Amgen (NASDAQ: AMGN ... full year 2014 financial results on Tuesday, Jan. 27, 2015, after ... followed by a conference call with the investment community at 2 ... Robert A. Bradway , chairman and chief executive officer, and other ...
(Date:1/22/2015)... , Jan. 22, 2015 Increasing sophistication among ... consolidation of localization purchasing in 2015, says Moravia ... to a recent study by market research firm Common ... single-source solution for their translation and localization needs. "From ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... "Allergy Diagnostics Market by Allergen Source, Product & by End ... offering. The global allergy diagnostics market is ... grow at a CAGR of 12.67%, to reach $2,230.72 million ...
Breaking Medicine Technology:Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
... When you are behind the wheel of a car, ... vehicles ahead and to the side, reading road traffic signs, ... and outside your vehicle in order to check the speedometer, ... station. During darkness these tasks can become even ...
... Medical Services Holdings Limited ("Concord Medical" or the "Company") (NYSE: ... of radiotherapy and diagnostic imaging centers in China, today announced ... quarter of 2011 after the market closes, at 6:00pm EST ... a conference call and live webcast to discuss the results ...
Cached Medicine Technology:Steering Drivers in the Right Direction, "Healthy Vision™ With Dr. Val Jones" Radio Show Offers Information, Advice About Driving in the Dark 2Steering Drivers in the Right Direction, "Healthy Vision™ With Dr. Val Jones" Radio Show Offers Information, Advice About Driving in the Dark 3Concord Medical to Announce Third Quarter 2011 Financial Results on November 14, 2011 2
... drainage from the ureteropelvic junction to ... packages. Intended for one-time use. CAUTION: ... Sof-Flex® stents must not remain indwelling ... stents must not remain indwelling more ...
... Pigtail Ureteral Stents have an exclusive ... migration. They also feature unique Tecoflex® ... savings. Each Classic Double PigTail Ureteral ... PigTail Ureteral Stent with attached braided ...
The Needle Loading Platform / Shield is designed to provide superior operator shielding during the loading of prostate implant needles with iodine or palladium seeds. It is constructed of 3/8" alumin...
The seed alignment tray aligns seeds and spacers for easy access to be picked up by the SeedVac™. It also interfaces with the seed sterilization and sorting tray for protection from radiation....
Medicine Products: