Scientists at the University of California reported that, a rapidly mutating gene in a virus that preys on bacteria may help lead to a new way to create artificial antibodies. This surprising mechanism may even be found in humans and other life, suggesting a new way of generating biological diversity.//
Jeff Miller, author of this study, the viruses are a treasure trove of fascinating biological mechanisms. This was one of those efforts that we were continuously surprised by as we learned more.
The researchers studied the bacterial family known as Bordatella. The germs are responsible for very contagious and potentially lethal respiratory diseases such as whooping cough. Bordatella is afflicted by a plague of its own, a kind of virus known as a bacteriophage or "bacteria eater." This phage infects Bordatella using its tail-like structures, which latch onto a specific molecule on the bacteria's surface.
To avoid the virus, the bacteria frequently switches its surface molecules, much as a person might switch their locks to prevent someone with a key from getting in. "In the world of microbial biowarfare, standing still in the face of a ferocious viral attack is a recipe for disaster," explained microbiologist Graham Hatfull of the University of Pittsburgh.
Bordatella can switch between two distinct forms -- one for colonizing the respiratory tracts of its hosts, and one better adapted for life outside a victim. The surface protein the phage latches onto is only present when Bordatella is in its colonizing phase.
The investigators, along with collaborators at the University of California in Santa Barbara and in Cambridge, England, discovered one in a million phage could remarkably generate trillions of possible keys to latch onto Bordatella's surface. The virus therefore rapidly keeps up with any of the bacteria's attempts to evolve resistance, adapting to attack the microbe even when the germ is not in a host.
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