Navigation Links
Mutated Gene Zaps Pancreas Cancer in Mice

A mutated gene named Bik can shrink or kill tumors in the pancreas of mice, US researchers said in a study published Monday, offering hope for one of the deadliest human cancers

The mutant gene named Bik expresses a protein that forces cancer cells to kill themselves, researchers from The University of Texas MD Anderson Cancer Center said.

The team even created a more lethal mutant, called BikDD, which spares healthy tissue.

"There are no good options for pancreatic cancer patients now," said James Abbruzzese, professor and chair of MD Anderson Department of Gastrointestinal Oncology.

Two types of mice were treated after they were infected with two aggressive lines of pancreatic cancer, one in a very advanced stage.

Infected control mice in both groups died within 40 days without treatment, while at least half those who received the aggressive BikDD mutant gene survived for 14 months with no signs of cancer.

"This vehicle, or vector, is so targeted and robust in its cancer-specific expression that it can be used for therapy and perhaps for imaging" that could lead to early cancer detection, said Mien-Chie Hung, professor and chair of Anderson center and senior author of the study.

"This looks like a promising approach to gene therapy for pancreatic cancer and we are working to bring it to a clinical trial," said Abbruzzese.

He estimated it will take between one and two years to complete US Food and Drug Administration requirements for Phase I clinical trial in humans. The side effects in mice were mild, they said, which is rare for cancer treatments.

Pancreatic cancer kills 96 percent of human victims within five years of diagnosis, one of the lowest cancer survival rates.

Some 37,000 cases of pancreatic cancer are diagnosed annually in the United States. Early diagnosis is extremely difficult, so the disease is often discovered at a late stage after it has already spread, or metastasized. br>

'"/>




Related medicine news :

1. Mutated Viruses Can Cure Tumors
2. Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias
3. Mutated Gene and Bad Habits can Lead to Age-related Macular Degeneration
4. Pancreas transplant gives hope to type 2 diabetes
5. Pancreas Transplant for Diabetics
6. Stomach Bruises Can Lead To Pancreas Infection
7. Once-Diabetic Heart/Kidney/Pancreas Transplant Recipient Enjoys Life (And Eating Again)
8. Fibroids unlikely to Turn Cancerous
9. Virus Level could Predict Cervical Cancer Risk
10. Cancer Doctors Okays Controversial Prostate Therapy
11. Potential New Cancer Gene Identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... ... January 23, 2017 , ... Ultimate ... K-20 Education Summit to be held March 23-25, 2017 in Tampa, and reminded ... 2017. , The keynote speakers include Dr. Michelle R. Weise, executive director of ...
(Date:1/23/2017)... ... January 23, 2017 , ... Sharon Kleyne, America’s leading water ... educate listeners about the benefits of making new water infrastructure a number one priority. ... appropriate that we expect water infrastructure to become a top priority of our new ...
(Date:1/23/2017)... ... January 23, 2017 , ... Steviva Ingredients, makers of all-natural ... USDA National Organic Program (NOP) for its Portland SQF Level 2 manufacturing facility. ... and handling systems to complement our current rigorous food-safety management systems,” said Yishu ...
(Date:1/23/2017)... ... ... a story of love and redemption, hope and uncertainty as a girl makes her ... Inn at the Mill” is the creation of published author, Lois Kulp, who was born ... Berks County on Crow Hill. The inn, the mill and "Post Yokel" are ...
(Date:1/23/2017)... , ... January 23, 2017 , ... Valentine’s Day is a time when many people ... ones. For those who may be looking for the ideal present, Atlanta-based Perimeter Plastic ... get an additional $25 free. Or, spend $200 and get $50 free. , “A ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... , January 20, 2017 According to ... (Descriptive, Prescriptive), Application (Marketing, R&D, Compliance, SCM), Component (Software, Service), Delivery ... Forecasts to 2021" published by MarketsandMarkets, the market is expected to ... 2016, at a CAGR of 13.3% during the forecast period. ... ...
(Date:1/21/2017)... Mass. , Jan. 20, 2017 /PRNewswire/ ... Keystone Symposia Conference, "PI3K Pathways in Immunology, ... Inc. (NASDAQ: INFI ) ... immuno-oncology development candidate that selectively inhibits phosphoinositide-3-kinase-gamma ... able to help overcome resistance to checkpoint ...
(Date:1/21/2017)... , Jan. 20, 2017  Faruqi & Faruqi, LLP, ... Inc. ("KemPharm" or the "Company") (NASDAQ: KMPH ) ... Company and certain officers and directors and underwriters of the ... seek the role of lead plaintiff. The lawsuit ... District Court for Johnson County on ...
Breaking Medicine Technology: