Navigation Links
Mutant Parasites, Unable to Infect Hosts, Highlight Virulence Genes

MADISON - With a single approach, microbiologists at the University of Wisconsin-Madison have identified dozens of clues to how human parasites may infect their hosts .

The researchers identified nearly 40 genes that, when mutated in the common parasite Toxoplasma gondii, prevented the parasite from forming an infection in the brains of mice. These potential "virulence factors" offer a smorgasbord of promising targets for developing drugs that could block or treat human parasitic infections such as malaria.

The new results are reported online this week in the Proceedings of the National Academy of Sciences. Though a larger problem in the developing world, parasitic infections are not uncommon in the U.S.

For example, Toxoplasma can infect any warm-blooded animal and is most commonly acquired from improperly cooked meat or by handling feces from infected cats. Pregnant women and people with weakened immune systems are at greatest risk from Toxoplasma infection, which can cause brain damage and death in unborn children and immune-compromised patients, such as AIDS patients.

Despite this, little is known about the factors that regulate parasites' abilities to infect their hosts, says Laura Knoll, professor of medical microbiology and immunology in the UW-Madison School of Medicine and Public Health and UW-Madison Waisman Center.

To study the question, Knoll and her colleagues at UW-Madison and the New York Medical College cast a wide net. Rather than analyze a single gene at a time for a role in virulence, they took the reverse approach, randomly mutating individual genes in the parasites, then looking to see which of the mutant parasites could no longer infect host brains.

"Let's let the parasite tell us what's important," Knoll says. The broad approach helped them uncover dozens of genes - many of them previously unknown - that may provide new clues about how parasites like Toxoplasma
'"/>




Page: 1 2

Related medicine news :

1. Mutant sperm beat out healthy brethren in study
2. Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants
3. New Drugs To Combat Mutant Bugs
4. Gene Transfer Using Mutant Form of Good Cholesterol Cuts Vascular Plaque and Inflammation
5. Chronic Kidney Disease Related To Mutant Gene
6. Sex Health Clinics Unable To Meet Increasing Demand
7. Patients With Filariasis More Prone To HIV Infection
8. Infection linked with heart attack
9. Link Between Infection And Heart Disease
10. Supplements for Ear Infections
11. Once-Daily Cipro(R) XR for Treating Complicated Urinary Tract Infections
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutant Parasites Unable Infect Hosts Highlight Virulence Genes

(Date:12/17/2014)... Unidesk Corporation today announced that ... welcomed its inaugural class in August 2013, has ... support bring your own device (BYOD) and deliver ... The solution, comprised of Citrix XenDesktop ... and storage infrastructure and Unidesk virtual ...
(Date:12/17/2014)... In its comprehensive analysis of medical claims, ... Review division have recently identified out-of-network and medical necessity ... are achieved on behalf of employer-clients. , The ... savings to Argus each year, with a total of ... Tom Doney, Cypress president and CEO, these in-depth medical ...
(Date:12/17/2014)... -- As gas prices rose in recent years, so ... In times of gas increases, more people start ... the researchers explained. They examined data gathered between ... number of motorcycle registrations in the United States and ... analysis revealed a strong association between rising gas prices ...
(Date:12/17/2014)... 16, 2014 (HealthDay News) -- Greater participation in music ... finds. Researchers followed kids in the nonprofit Harmony ... children in Los Angeles. Over two years, children ... in how the brain processes speech and reading, compared ... the benefits of active participation in music classes occurred ...
(Date:12/15/2014)... 2014 A recent survey found that ... as impacting skin health and beauty were: “Connections,” “climate,” ... care.” Water and health advocate and radio host Sharon ... describing the survey and the Four C’s.* Kleyne notes, ... category discussed would benefit from paying attention to one’s ...
Breaking Medicine News(10 mins):Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 2Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 3Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2Health News:Music Classes Boost Language Skills, Study Says 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3
... The UK government has planned to outlaw sex selection of ... embryology regulation.// ,Health Minister Caroline Flint has told ... ban" on the use of techniques to choose a gender ... could be the start of a "slippery slope" to designer ...
... of the growing imbalance between the number of organ donations ... ,Statistics show that only 22 per cent of ... In addition it has been found that while 6,700 patients ... ,The NHS has designated this week as National ...
... shortage of staff at the accident and emergency units, doctors ... casualty departments is a move to bail the NHS out ... Medicine (BAEM). ,Last year, Bristol's South Mead Hospital ... Canterbury Hospitals have stopped catering to trauma patients. ...
... Middle-aged women could maintain their weight by consuming adequate amounts ... Journal of the American Dietetic Association//. Researchers from the Fred ... 10,591 men and women aged 53 to 57 years. ... in men, but women who took at least 500 milligrams ...
... salaries of doctors participating in the anti-quota stir was likely to ... to do so was issued on the direction of Director P ... who was asked to explain the reason behind the order to ... was asked to relinquish charge as Registrar by the Director on ...
... of then Archidiocese of Goa and Daman has advocated voluntary ... ,Reacting to reports in sections of the media about a ... tests mandatory before marriage to arrest the spread of AIDS, ... not mandatory"., ,"Respecting the conscience and the freedom that ...
Cached Medicine News:Health News:National Transplant Week to Raise Need for Organ Donation 2
(Date:12/13/2014)...  Radiologists can transmit their reports, which can ... physicians, electronic health records (EHR) systems securely, efficiently, ... That was the message behind a ... the recent Radiology Society of North America Meeting ... in this manner also helps referring physicians satisfy ...
(Date:12/13/2014)... China , Dec 12, 2014 Mindray ... a leading developer, manufacturer and marketer of medical devices ... general meeting of shareholders held in Hong ... At the meeting, Mindray shareholders voted to re-elect incumbent ... a three-year term. Mindray,s shareholders did not re-elect ...
(Date:12/13/2014)... INDIANAPOLIS , Dec. 12, 2014  Novo Nordisk, ... Teams (CGRT), today announced a multi-year extension of their partnership, ... the No. 83 Novo Nordisk Chip Ganassi Racing entry, driven ... Kimball, 29, from Camarillo, California ... diabetes in the history of INDYCAR to win a race ...
Breaking Medicine Technology:Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3Mindray Announced Shareholder Resolutions Post 2014 Annual General Meeting 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: