Navigation Links
Mushroom found to be a source of a new antibiotic: Plectasin

Animals and higher plants are known to express endogenous peptide antibiotics called defensins, which are small cysteine-rich peptides found to be active against bacteria, fungi and viruses//.

A recent research, published in the October issue of Nature, describes plectasin-the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high, and commercially viable, yield and purity at the Danish biotechnology company Novozymes.

During the studies, the compound showed potent activity against a range of Gram-positive bacteria, including several strains resistant to conventional antibiotics, but was found less effective against Gram-negative microbes, the researchers noted.

In mice inoculated with a potentially lethal dose of S. pneumoniae in the peritoneum, plectasin was as effective as vancomycin. Plectasin treated mice were more likely to be alive seven days after infection compared with mice in the control arm. In a mouse model of pneumonia, plectasin and penicillin again had comparable efficacy, the researchers found.

The compound showed no evidence of toxicity in the mice, and is excreted without change in the urine of mice, which is a sign that it is safe and effective. However, the authors add that further study will be needed to see if it is safe to use in humans.

The results indicate that Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin.

The authors conclude on the note that these findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects , molluscs and fungi arose from a common ancestral gene.
'"/>




Related medicine news :

1. Mushroom and muscle loss
2. Mushrooms can help fight chronic disease
3. Mushroom found to contain powerful antibiotic
4. Novel Vitamin D source in Mushrooms!
5. Mushrooms are Rich Source of Antioxidants
6. A Mushroom Extract May Impact the Body’s Immune Syste
7. Four of Family Died After Consuming Poisonous Mushrooms
8. Mushroom Extract Protects Poultry From Parasite Diseases
9. Magic Mushrooms Treat Obsessive Compulsion Disorder
10. Private Health-care Clinics Mushroom in Ontario
11. Much Room for Cancer Cure in a Mushroom, Scientists Promise
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/28/2017)... ... July 28, 2017 , ... Kevin Harrington, one of the original Sharks from hit reality ... of a new DRTV campaign with My Real Earth. , Most people put their healthcare ... just as important as what we put in our bodies. After all, the skin is ...
(Date:7/28/2017)... ... July 28, 2017 , ... Date aired: July 17th, ... , Like millions of first generation immigrants before her, Rose Hong came to America ... and sacrifice on the part of loving parents who made sure their daughter got ...
(Date:7/28/2017)... ... ... The DuPage County law firm of Mirabella Kincaid Frederick & Mirabella, ... Cusack joins the team ready to provide clients with vigorous representation in a number ... Illinois, with a BA in Social Work. She earned her JD from Western Michigan ...
(Date:7/28/2017)... ... 2017 , ... As many parents, students, and teachers are getting ready to ... acuity and address mental fatigue that can accompany long study hours, homework sessions, and ... not only helps with school work but also in day-to-day functions on the job ...
(Date:7/28/2017)... ... July 28, 2017 , ... Join Becker's Healthcare as they host ... 2017 in Chicago IL. Great sessions on Epic, Cyber Security, Telehealth, Mobile Health, Revenue ... discussion talks by:, George W. Bush, 43rd President of ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today announced financial ... 2017, and updated its financial outlook for fiscal 2017. ... fiscal third quarter, Hill-Rom reported earnings of $0.09 per ... the prior-year period. These results reflect after-tax special items, ... related to the non-cash write-down of assets associated with ...
(Date:7/28/2017)... FLINT, Mich. , July 28, 2017 EnvoyHealth, ... (CMT) to pilot a program for CleverCap LITE, a ... CMT strives to deliver innovative health technology solutions ... adherence. CleverCap LITE ... The compact, high-tech bottle cover: ...
(Date:7/27/2017)... WARSAW, Ind., July 27, 2017  Zimmer Biomet Holdings, ... the quarter ended June 30, 2017.  The Company reported ... of 1.1% over the prior year period, and an ... approximately 240 basis points of contribution from the LDR ... from the second quarter of 2016, or 0.3% on ...
Breaking Medicine Technology: