Navigation Links
Mushroom found to be a source of a new antibiotic: Plectasin

Animals and higher plants are known to express endogenous peptide antibiotics called defensins, which are small cysteine-rich peptides found to be active against bacteria, fungi and viruses//.

A recent research, published in the October issue of Nature, describes plectasin-the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high, and commercially viable, yield and purity at the Danish biotechnology company Novozymes.

During the studies, the compound showed potent activity against a range of Gram-positive bacteria, including several strains resistant to conventional antibiotics, but was found less effective against Gram-negative microbes, the researchers noted.

In mice inoculated with a potentially lethal dose of S. pneumoniae in the peritoneum, plectasin was as effective as vancomycin. Plectasin treated mice were more likely to be alive seven days after infection compared with mice in the control arm. In a mouse model of pneumonia, plectasin and penicillin again had comparable efficacy, the researchers found.

The compound showed no evidence of toxicity in the mice, and is excreted without change in the urine of mice, which is a sign that it is safe and effective. However, the authors add that further study will be needed to see if it is safe to use in humans.

The results indicate that Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin.

The authors conclude on the note that these findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects , molluscs and fungi arose from a common ancestral gene.
'"/>




Related medicine news :

1. Mushroom and muscle loss
2. Mushrooms can help fight chronic disease
3. Mushroom found to contain powerful antibiotic
4. Novel Vitamin D source in Mushrooms!
5. Mushrooms are Rich Source of Antioxidants
6. A Mushroom Extract May Impact the Body’s Immune Syste
7. Four of Family Died After Consuming Poisonous Mushrooms
8. Mushroom Extract Protects Poultry From Parasite Diseases
9. Magic Mushrooms Treat Obsessive Compulsion Disorder
10. Private Health-care Clinics Mushroom in Ontario
11. Much Room for Cancer Cure in a Mushroom, Scientists Promise
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... Lafayette, California (PRWEB) , ... ... ... a pioneer in the patient payment industry today announced its strategic partnership ... and health system workflows. , The two companies’ proven, proprietary technology combine ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: