Navigation Links
Mushroom found to be a source of a new antibiotic: Plectasin

Animals and higher plants are known to express endogenous peptide antibiotics called defensins, which are small cysteine-rich peptides found to be active against bacteria, fungi and viruses//.

A recent research, published in the October issue of Nature, describes plectasin-the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high, and commercially viable, yield and purity at the Danish biotechnology company Novozymes.

During the studies, the compound showed potent activity against a range of Gram-positive bacteria, including several strains resistant to conventional antibiotics, but was found less effective against Gram-negative microbes, the researchers noted.

In mice inoculated with a potentially lethal dose of S. pneumoniae in the peritoneum, plectasin was as effective as vancomycin. Plectasin treated mice were more likely to be alive seven days after infection compared with mice in the control arm. In a mouse model of pneumonia, plectasin and penicillin again had comparable efficacy, the researchers found.

The compound showed no evidence of toxicity in the mice, and is excreted without change in the urine of mice, which is a sign that it is safe and effective. However, the authors add that further study will be needed to see if it is safe to use in humans.

The results indicate that Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin.

The authors conclude on the note that these findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects , molluscs and fungi arose from a common ancestral gene.
'"/>




Related medicine news :

1. Mushroom and muscle loss
2. Mushrooms can help fight chronic disease
3. Mushroom found to contain powerful antibiotic
4. Novel Vitamin D source in Mushrooms!
5. Mushrooms are Rich Source of Antioxidants
6. A Mushroom Extract May Impact the Body’s Immune Syste
7. Four of Family Died After Consuming Poisonous Mushrooms
8. Mushroom Extract Protects Poultry From Parasite Diseases
9. Magic Mushrooms Treat Obsessive Compulsion Disorder
10. Private Health-care Clinics Mushroom in Ontario
11. Much Room for Cancer Cure in a Mushroom, Scientists Promise
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... June 23, 2016 The Biotechnology ... continues to present great opportunities to investors. Stock-Callers.com assesses ... Intrexon Corp. (NYSE: XON ), Vertex Pharmaceuticals ... (NASDAQ: ARNA ), and Regeneron Pharmaceuticals Inc. ... stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: