Navigation Links
'Muscle' Protein Drives Prostate Cancer

Researchers at the Johns Hopkins Kimmel Cancer Center have for the first time implicated the muscle protein myosin VI in the development //of prostate cancer and its spread.

In a series of lab studies with human prostate cancer cells, the Hopkins scientists were surprised to find overproduction of myosin VI in both prostate tumor cells and precancerous lesions. When the scientists genetically altered the cells to 'silence' myosin VI, they discovered the cells were less able to invade in a test tube.

'Our results suggest that myosin VI may be critical in starting and maintaining the malignant properties of the majority of human prostate cancers diagnosed today,' says Angelo M. De Marzo, M.D., Ph.D., a study coauthor and associate professor of pathology, urology and oncology.

The Hopkins work, published in the November issue of the American Journal of Pathology, has potential value for better ways to diagnose the disease, treat and track the effects of drugs and surgery. 'Targeting myosin VI represents a promising new approach that could lead eventually new approaches to treating the disease,' says Jun Luo, Ph.D., senior author of the paper and assistant professor of urology.

Myosins are a class of 40 motor proteins that power cell movement and muscle contractions. Normally, as they work, myosins slide in a single direction along the threads of a protein called actin. But myosin VI moves against the grain, and it does not function as a classical 'muscle' protein.

Using a DNA microarray to study all of the genes in 59 samples of benign or cancerous prostate tissue from patients at Johns Hopkins, the researchers found the malignant samples showed a 3.7-fold higher expression of myosin VI as compared to normal samples, and a 4.6-fold increase as compared to the samples from patients with enlarged prostate.

Next, the researchers hunted for myosin VI in 240 prostate tissue samples, discovering overprod
'"/>




Page: 1 2

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Muscle Protein Drives Prostate Cancer

(Date:7/31/2014)... David Kekich, anti-aging icon and CEO of ... that the acceptance of his revolutionary approach of ... algorithms and then screening thousands of compounds against ... , “It took longer than I thought and ... said Kekich. "Client acceptance is exploding, early clinical ...
(Date:7/31/2014)... Malaysia (PRWEB) July 31, 2014 ... mymobileuni.com, entered into strategic alliance with Dr. Lawrence ... and provide content to http://www.mymobileuni.com its ... Channel http://www.mymobileuni.net/mu3/health.php will include courses, e-books ... who want to learn, re-skill or up-skill themselves ...
(Date:7/31/2014)... 2014 (HealthDay News) -- The virus that causes cold sores ... the absence of symptoms, according to a new study. ... the cells of people infected with the virus. This explains ... and why others get them only occasionally. The authors said ... "We thought when the disease was dormant, it ...
(Date:7/31/2014)... MO (PRWEB) July 31, 2014 Saint ... with an Excellence Through Insight award for Overall Patient ... and Systems (CG-CAHPS) database in multiple categories by HealthStream, ... their commitment to excellence in patient care. To qualify ... been a patient satisfaction-tracking client of HealthStream in 2013, ...
(Date:7/31/2014)... OK (PRWEB) July 31, 2014 Shiitakes ... As in the recipe for Quick-Fix Spaghetti Sauce below, ... second-most consumed mushroom worldwide, valued for their deep flavor ... mushrooms. They absorb flavors of the foods they're cooked ... texture and offer high-protein, low-fat nutrition. Shiitakes are rich ...
Breaking Medicine News(10 mins):Health News:MaxLife Solution™ Expands Distribution Globally for Breakthrough Anti-Inflammatory Support Supplement – InflaGene™ 2Health News:MyMobileUniversity and Fortech International Form Strategic Alliance That Will Enhance the Global Health and Medical Channel on Its Website 2Health News:Cold Sore Virus Active Without Symptoms, Study Finds 2Health News:Saint Luke’s Health System Physicians and Clinics Earn Excellence through Insight Awards for Overall Patient Experience in the CG-CAHPS Database 2Health News:Saint Luke’s Health System Physicians and Clinics Earn Excellence through Insight Awards for Overall Patient Experience in the CG-CAHPS Database 3Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 2Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 3
... encouraging results for the long-term efficacy of a meningitis ... effective when given to infants older than 5 months.// ... the United Kingdom in 1999. While the short-term effectiveness ... a study looking at the data from the four ...
... risk of developing dementia later in life, a healthy diet ... conducted, researchers followed nearly 1,500 participants for more than 20 ... were twice as likely to develop dementia later in life. ... in middle age were six-times more likely to develop dementia ...
... suggests that older patients can avoid the risk of stroke by ... who ate fish; one to four// times a week had ... atrial fibrillation), than those who ate fish less than once a ... greater benefit – as their risk was lowered by 31%. However ...
... on active baby boomers. Arthritis followed by knee replacement surgery ... middle-aged Americans. Now a new technique offers hope for active ... feet, crouching and clicking, kneeling and directing. His glamour photography ... lifeblood," he says. "If they don't work, I don't work." ...
... it safe for people with heart disease to travel by ... on // issues involving air travel for heart patients -- ... on implantable automatic defibrillators and pacemakers, the need for preflight ... dangerous blood clot that can arise in the leg when ...
... heart attack patients fare better after having a procedure to ... results // from a recent study. The study, conducted in ... a group of about 870 men and about 160 women ... heart attack. While both sexes had about the same success ...
Cached Medicine News:
(Date:7/31/2014)... July 31, 2014 Touro University California,s College ... selected as the recipient of a $150,000 grant by ... the University to increase research and classroom space on ... technology for the study of health sciences, and will ... needs and interests of our students," said Shelley ...
(Date:7/31/2014)... , July 31, 2014 Hovione today ... has successfully passed a pre-approval inspection by the ... carried out by the FDA Consumer Safety Officer, Ms. ... on 21 st July and concluded on the 25 ... with the principles and guidelines of Good Manufacturing Practices (GMP) ...
(Date:7/31/2014)... SAN FRANCISCO , July 31, 2014 /PRNewswire/ ... ) and Aspira Scientific ( Milpitas, California ... joint venture to develop and commercialize new fluorination ... biologically active molecules has benefited from the use ... metabolism, and combine lipophilicity with polarity to improve ...
Breaking Medicine Technology:Touro University California Garners Grant From Long Foundation 2Successful FDA Inspection at Hovione's API Manufacturing Plant in Cork, Ireland 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2
... MVP Marketing + Design, Inc., a Minneapolis-based, branding, communications ... of eleven American Graphic Design Awards for selected client ... online and retail promotions created for three separate divisions ... (Skin and Wound Care, Office Supplies and Stationery Products), ...
... announces the approval of CollaGUARD surgical adhesion barrier for ... surgery. The product will be launched this year through ... to seek approval in a number of additional territories, ... and to initiate the studies required for registration in ...
Cached Medicine Technology:MVP Sweeps 2011 American Graphic Design Awards with Nine of 11 Wins for 3M Projects 2Innocoll Announces European Approval for CollaGUARD®, Surgical Adhesion Barrier 2Innocoll Announces European Approval for CollaGUARD®, Surgical Adhesion Barrier 3
Substrate Plasma for Factor IX Assay by STA© Analyzers. Freeze-dried human plasma from which factor IX has been removed by selective immuno-adsorption....
Colorimetric Assay of Plasminogen Activity by STA© Analyzers....
Enzyme Immunoassay of -Thromboglobulin Antigen by ELISA Method, 96 tests....
Calibration Plasmas for Assaysof Unfractionated Heparins (UFH) using the Anti-Xa Method on STA© Analyzers....
Medicine Products: