Navigation Links
'Muscle' Protein Drives Prostate Cancer

Researchers at the Johns Hopkins Kimmel Cancer Center have for the first time implicated the muscle protein myosin VI in the development //of prostate cancer and its spread.

In a series of lab studies with human prostate cancer cells, the Hopkins scientists were surprised to find overproduction of myosin VI in both prostate tumor cells and precancerous lesions. When the scientists genetically altered the cells to 'silence' myosin VI, they discovered the cells were less able to invade in a test tube.

'Our results suggest that myosin VI may be critical in starting and maintaining the malignant properties of the majority of human prostate cancers diagnosed today,' says Angelo M. De Marzo, M.D., Ph.D., a study coauthor and associate professor of pathology, urology and oncology.

The Hopkins work, published in the November issue of the American Journal of Pathology, has potential value for better ways to diagnose the disease, treat and track the effects of drugs and surgery. 'Targeting myosin VI represents a promising new approach that could lead eventually new approaches to treating the disease,' says Jun Luo, Ph.D., senior author of the paper and assistant professor of urology.

Myosins are a class of 40 motor proteins that power cell movement and muscle contractions. Normally, as they work, myosins slide in a single direction along the threads of a protein called actin. But myosin VI moves against the grain, and it does not function as a classical 'muscle' protein.

Using a DNA microarray to study all of the genes in 59 samples of benign or cancerous prostate tissue from patients at Johns Hopkins, the researchers found the malignant samples showed a 3.7-fold higher expression of myosin VI as compared to normal samples, and a 4.6-fold increase as compared to the samples from patients with enlarged prostate.

Next, the researchers hunted for myosin VI in 240 prostate tissue samples, discovering overprod
'"/>




Page: 1 2

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Muscle Protein Drives Prostate Cancer

(Date:7/13/2014)... TX (PRWEB) July 13, 2014 The Pearland, ... children ranging in age from four months to 12 years ... and karate classes to birthday parties and Summer Camps, is ... Little Gym of Pearland after spending over six ... of roles, including Gym Director. , Berry has over ...
(Date:7/13/2014)... Recently, MyDressCity.com, one of the most popular suppliers of ... its new range of elegant Quinceanera dresses . ... discounted prices. Worldwide clients can enjoy this special offer ... online shop, there are plenty of beautiful dresses for ... materials. MyDressCity.com’s hot items are prom gowns, bridesmaid gowns, ...
(Date:7/13/2014)... 13, 2014 According to the Kidney Disease ... step by step guide on what to do to eliminate ... quickly. Vkool writes in its review that readers can easily ... to revitalize their kidney health. Vkool also informs in its ... reverse their damaged kidney functions naturally. The book consists of ...
(Date:7/13/2014)... Hope Palliative & Hospice Care announced today that they will ... Senior Living Community in Palatine, IL. The group, called “New ... Wednesdays of every month. This group will begin on ... 55 S. Greeley St. Palatine, IL 60067. It is ... for the group. , “A grief support group is ...
(Date:7/12/2014)... 13, 2014 According to the new ... Systems, Airborne Systems, and Naval Systems) - Global Forecasts ... Security and Surveillance Radar market are estimated to be ... a CAGR of 5.97% to reach $8.61 billion by ... with 47 figures spread through 161 pages and in-depth ...
Breaking Medicine News(10 mins):Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2Health News:Cheap Elegant Quinceanera Dresses Unveiled by MyDressCity.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3Health News:Hope Hospice Announces Grief Support Group at the Tamarack Senior Living Community 2Health News:Security and Surveillance Radar Market Estimated to Reach $8.61 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Security and Surveillance Radar Market Estimated to Reach $8.61 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Security and Surveillance Radar Market Estimated to Reach $8.61 Billion by 2020 – New Report by MarketsandMarkets 4
... a startling find. Around 75 percent of whites or those ... of developing heart diseases. And that’s not all. These genes ... diabetes. ,The findings, made by two independent groups of ... even if they do not have clear risk factors such as ...
... American doctor has threatened to mobilise US congressmen and senators ... Information (RTI) Act in a case relating to his crusade ... Saha, whose wife died of alleged wrongful treatment in India ... my senators and congressmen in US and will ask them ...
... Human Resource Development in collaboration with National AIDS Control ... Adolescence Education Programme (AEP) which is being implemented by ... ,The Programme is aimed at the ... of the major concerns, i.e. process of growing up ...
... that can enable the blind to hear what they cannot see ... texts through an embedded system and converts them into voice that ... can only read text, but later it is likely to pick ... that took six months to develop the device and the software ...
... to detect epidemic diseases has entered the phase of clinical ... methods that rely on antigen or antibody test, the new ... DNA or RNA, to confirm epidemic diseases such as hepatitis ... Centre of US National Institutes of Health (NIH). ...
... and women who consumed higher levels of calcium and vitamin ... brain lesions, regions of damage// that can increase risk of ... Payne and her co-investigators from Duke and the University of ... men and women (79 men, 153 women) between the ages ...
Cached Medicine News:Health News:Gene Mutations Leave Caucasians Prone To Heart Diseases And Diabetes 2Health News:NRI Threatens to Move US Congress for Justice in India 2Health News:Higher Intake of Calcium and Vitamin D Linked With Brain Lesions in Older People 2
(Date:7/10/2014)... Calif. , July 10, 2014 Integrated ... leader in advanced memory and analog IC solutions, today ... on Thursday, July 24, 2014, at 7:00 a.m. Pacific ... financial results for the fiscal 2014 third quarter ended ... call via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific ...
(Date:7/10/2014)...  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... the sale to Galderma of all rights to Restylane, ... Valeant for $1.4 billion in cash, pursuant to the ... its acquisition of Galderma. "We are ... a company that is firmly committed to the aesthetic ...
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
Breaking Medicine Technology:
... Calif., Oct. 10 Amgen (Nasdaq:  AMGN) today ... pivotal Phase 3 trials comparing denosumab to Zometa® ... the prevention of skeletal related events (SREs) in ... separate analyses, denosumab demonstrated a clinically meaningful, consistent ...
... Oct. 8 The American Dental Association (ADA) has ... ), the largest provider of health care products and ... at $860,000 to students in the Community Dental Health ... initially for hands-on clinical training in the program, which ...
Cached Medicine Technology:Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 2Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 3Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 4Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 5Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 6Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 7Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 8Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 9Integrated Analysis Demonstrates That Denosumab Delays the Onset of Bone Complications Compared to Zometa® 10Henry Schein Inc. Donates Equipment to ADA Community Dental Health Coordinator Pilot Program 2Henry Schein Inc. Donates Equipment to ADA Community Dental Health Coordinator Pilot Program 3
... The Asnis III™ Cannulated Screw System has ... and TCS Systems and combined them to ... screws in both titanium and stainless steel. ... System is designed to optimize surgical outcomes ...
The 6.5mm cannulated cancellous ACE SCFE Screw is specifically designed for the treatment of slipped capital femoral epiphysis. The ACE SCFE Screw simplifies insertion and facilitates removal....
... a wide variety of cannulated screw products. ... partially threaded and fully threaded versions. , ... and 7.0 mm products. These incorporate innovative ... a little easier. Ratchet screwdrivers have proven ...
Biomet® Arthrodesis Nail indications include: , Failed external fixation , Aseptic failed total knee arthroplasty , Periarticular fractures where repair is not possible , Limb salvage in tumor...
Medicine Products: