Navigation Links
Muscle Derived Stem Cell Can Repair Damaged Cartilage

Researchers have now unraveled the potential of stem cells in the repair and treatment of damaged cartilage. It is now possible to harvest stem cells from muscle tissue // of injured rats and genetically engineer the same to induce expression of a therapeutic protein (bone morphogenetic protein 4, BMP-4, capable of repairing damaged cartilage. It is possible that such a repair mechanism can be instituted in humans as well.

There is currently no proper available technique for effective tissue repair following injury to the articular cartilage in humans. Dr. Huard and colleagues, involved in the present study have expressed that the above technique could revolutionize treatment through enhanced articular cartilage healing. The results of this promising study can be found in the latest issue of Arthritis and Rheumatism.

The researchers extracted stem cells from the muscle. The harvested cells were transduced with the help of a retroviral vector, to enable expression of the BMP-4 protein, known to promote chondrogenesis.

Simultaneously, the knee cartilage of 12-week rats were injured and treated with genetically altered stem cells in fibrin glue. In order to observe any therapeutic effect, the rats were treated with either unmodified stem cells in fibrin glue or the glue itself. These rats represented the control group.

Following 8 weeks of treatment, the experimental group rats were found to have a well-repaired tissue as revealed by a glossy white appearance. In rats that formed the control group, the repair was however inadequate, as revealed by a patchy and moderate integration with the adjacent normal cartilage.

This difference in tissue appearance was further enhanced at the end of 12 and 24 weeks. The use of stem cells was found to result in smooth and uniform tissue repair, without ossification. Signs of osteoarthritic changes and a clear-cut demarcation between the healthy and the injured tissue were evident in the control group.

The use of a binding agent (in this case, fibrin) is an important parameter that determined the success of the experiment. It allowed the migration of cells even into small breaks and accelerated the integration of the new tissue.

With our improved understanding of stem cell therapy from such experiments, it would not be long before a famous sports personality opts for a stem cell transplant to repair his injured knee.


'"/>




Related medicine news :

1. Protein said to Improve Muscle Loss
2. ‘Protein’ Produced By Overstressed Heart Muscle a Strong Indicator Of Heart Diseae
3. Protein Found To Improve Muscle Loss
4. Strong Pelvic Muscles Found To Facilitate Childbirth
5. Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting
6. Scientists identify Genes Needed For Muscle Development
7. $ 1.7 Million NYSTAR Award for Binghamton University to Flex Electronics Research Muscle.
8. Stem Cell Therapy Regenerates Heart Muscle In Heart Attack Patients
9. Expect Aching Muscles And Joints This Sports Season
10. Acetaminophen does not Protect Heart Muscle
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... Pro X users can now reveal the media of their split screens with ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
Breaking Medicine Technology: