Navigation Links
Muscle Derived Stem Cell Can Repair Damaged Cartilage

Researchers have now unraveled the potential of stem cells in the repair and treatment of damaged cartilage. It is now possible to harvest stem cells from muscle tissue // of injured rats and genetically engineer the same to induce expression of a therapeutic protein (bone morphogenetic protein 4, BMP-4, capable of repairing damaged cartilage. It is possible that such a repair mechanism can be instituted in humans as well.

There is currently no proper available technique for effective tissue repair following injury to the articular cartilage in humans. Dr. Huard and colleagues, involved in the present study have expressed that the above technique could revolutionize treatment through enhanced articular cartilage healing. The results of this promising study can be found in the latest issue of Arthritis and Rheumatism.

The researchers extracted stem cells from the muscle. The harvested cells were transduced with the help of a retroviral vector, to enable expression of the BMP-4 protein, known to promote chondrogenesis.

Simultaneously, the knee cartilage of 12-week rats were injured and treated with genetically altered stem cells in fibrin glue. In order to observe any therapeutic effect, the rats were treated with either unmodified stem cells in fibrin glue or the glue itself. These rats represented the control group.

Following 8 weeks of treatment, the experimental group rats were found to have a well-repaired tissue as revealed by a glossy white appearance. In rats that formed the control group, the repair was however inadequate, as revealed by a patchy and moderate integration with the adjacent normal cartilage.

This difference in tissue appearance was further enhanced at the end of 12 and 24 weeks. The use of stem cells was found to result in smooth and uniform tissue repair, without ossification. Signs of osteoarthritic changes and a clear-cut demarcation between the healthy and the injured tissue were evident in the control group.

The use of a binding agent (in this case, fibrin) is an important parameter that determined the success of the experiment. It allowed the migration of cells even into small breaks and accelerated the integration of the new tissue.

With our improved understanding of stem cell therapy from such experiments, it would not be long before a famous sports personality opts for a stem cell transplant to repair his injured knee.


'"/>




Related medicine news :

1. Protein said to Improve Muscle Loss
2. ‘Protein’ Produced By Overstressed Heart Muscle a Strong Indicator Of Heart Diseae
3. Protein Found To Improve Muscle Loss
4. Strong Pelvic Muscles Found To Facilitate Childbirth
5. Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting
6. Scientists identify Genes Needed For Muscle Development
7. $ 1.7 Million NYSTAR Award for Binghamton University to Flex Electronics Research Muscle.
8. Stem Cell Therapy Regenerates Heart Muscle In Heart Attack Patients
9. Expect Aching Muscles And Joints This Sports Season
10. Acetaminophen does not Protect Heart Muscle
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
(Date:6/24/2016)... Las Vegas, Nevada (PRWEB) , ... June 24, ... ... their Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and ... The Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer ...
(Date:6/24/2016)... ... 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... service members that have been wounded in battle and their families. Venture Construction Group ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology: