Navigation Links
Multiple Sclerosis drug, Tysabri banned due to neurological disorders

Tysabri, which is used in the treatment of Multiple Sclerosis (MS), has been withdrawn from market after the two patients taking the drug complained of neurological disorders. The relationship between the drug and // Progressive Multifocal Leukoencephalopathy (PML) is being researched by the scientists. If the drug is deemed to pose a significant risk, it could be a serious setback for the entire class of drugs, which work by blocking passage of immune cells in to the brain.

“Other cell migration inhibitors in development will have to be carefully tested, says Howard Weiner, director of the partners MS center at Brigham and Women’s Hospital. Several companies are developing drugs that use the same compounds to treat Crohn disease, rheumatoid arthritis and asthma. The US FDA has halted a phase 2 trial of a GlaxoSmithKline drug that targets the same protein, alpha-4 integrin, as Tysabri. Australian biotech Antisense Therapuetics stopped Phase 2 trial in March for similar MS drugs, which the company had also planned to develop as an asthma treatment. The FDA in November 2004 granted Tysabri fast track approval, after initial phase 3 results attacks by as much as 66%. Tysabri was expected to be a major blockbuster for its manufacturer Biogen Idec, but the company suspended sales of Tysabri in February, after learning of the two PML cases, one of which was fatal. The company also halted trials of the drug for rheumatoid arthritis and Crohn disease.

There has never previously been a documented case of PML in MS patients, even though these patients have been treated with many types of immunosuppresants. Both patients diagnosed with PML had taken Tysabri with Avonex, another MS drug, for two years n clinical trials.

Source: Nature Medicie

Page: 1

Related medicine news :

1. Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
2. Multiple organ disease cured by genes
3. Adult stem cells in treatment for Multiple sclerosis (MS)
4. Life Quality For Patients With Multiple Sclerosis
5. Effective Pain Relief For Patients Suffering From Multiple Sclerosis
6. The Link Between Hepatitis B Vaccine And Multiple Sclerosis Questioned
7. Hope For Patients With Multiple Sclerosis
8. Individuals Born In May At A Higher Risk Of Developing Multiple Sclerosis
9. Debating The Link Between Sex Hormones And Multiple Sclerosis
10. Warning Issued by FDA on consumption of the drug Tysabri used to treat Multiple Sclerosis
11. Decreasing Multiple Births By Single Embryo Transfers
Post Your Comments:

(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... ... benefits advisory organization, is pleased to welcome Winter-Dent & Company as its newest ... from day one to become a client's most trusted advisor regardless of whether ...
(Date:11/24/2015)... ... November 24, 2015 , ... Serenity Point Rehabilitation, a ... of recent video interviews with some of the staff members at their recovery center. ... treatment facility, as well as some of the things that make their recovery program ...
(Date:11/24/2015)... ... November 24, 2015 , ... Abington Hospital ... Aetna Institute of Quality® Bariatric Surgery Facility for treating individuals living with morbid ... health care services available to its members to help them make informed decisions ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... and Healthy Aging Program have announced their endorsement of the Medical Fitness ... Health Fitness is proud to have the MFN as one of our endorsed ...
(Date:11/24/2015)... ... November 24, 2015 , ... World Patent ... Blending, a household invention that revolutionizes the vending machine industry by providing healthy ... is worth $2 billion," says Scott Cooper, CEO and Creative Director of World ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015  DILON Diagnostics and GE Healthcare are ... for DILON to distribute GE,s Discovery NM750b Molecular Breast ... of this distribution agreement will provide Dilon,s experienced distribution ... system and is considered an initial step in an ... for clinicians and their patients. --> ...
(Date:11/24/2015)... COMMACK, N.Y. , Nov. 24, 2015 ... Pacemaker System, is pleased to announce the appointment of ... ... and pediatric cardiology at Children,s Hospital, Uppsala University, Uppsala ... . From 1984-1986, he was a fellow at the ...
(Date:11/24/2015)... BERN, Switzerland , November 24, 2015 ... for Biomedical Engineering Research of the University of ... Endocrinology, Diabetes and Clinical Nutrition of the Bern University ... an exclusive collaboration to develop a novel generation artificial ... personalised delivery of insulin for diabetic patients with the ...
Breaking Medicine Technology: