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Multiple Sclerosis Patients to Benefit With AVONEX(R) Nurse Services Program

AVONEX can now be administered with a smaller needle, which can further advance patient comfort. The storage and transportation of AVONEX has been made even easier with the introduction of ambient storage for the AVONEX luer-lock prefilled syringe. A new AVOGRIP(TM) is available to aid patients in the administration of injections. These improvements are part of the company's efforts to improve patients' experience with AVONEX. In addition, AVONEX patients have shown significantly higher adherence rates than the other approved disease-modifying therapies (DMTs).(1)

AVONEX is the most prescribed treatment for relapsing forms of MS worldwide, with more than 130,000 patients on therapy. It was launched in the U.S. in 1996 and later in Europe for the treatment of relapsing forms of MS to slow the progression of disability and reduce relapses. AVONEX is marketed internationally in more than 90 countries.

AVONEX was the first treatment approved for patients who have their first clinical MS attack and have a brain MRI scan consistent with MS; this use was approved in Europe in 2002 and in the U.S. in 2003. The most common side effects associated with AVONEX multiple sclerosis treatment are flu-like symptoms, including myalgia, fever, fatigue, headache, chills, nausea, vomiting, pain and asthenia.

AVONEX should be used with caution in patients with depression or other mood disorders and in patients with seizure disorders. AVONEX should not be used by pregnant women. Patients with cardiac disease should be closely monitored. Patients should also be monitored for signs of hepatic injury. Routine periodic blood chemistry and hematology tests are recommended during treatment with AVONEX. Rare cases of anaphylaxis have been reported

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