Navigation Links
Multiple Course of Steroids Protects Preterm Baby’s Lung

A recent study finds that repeated courses of steroids to women in preterm labor do not result in brain damage of the baby in the womb as believed// and that the treatment enhances the survival rate of the babies.

"The consensus in recent years has been to no longer give women in preterm labor more than one course of steroids because of possible adverse effects, but it means more babies are born needing ventilation," said Sanjiv Amin, M.D., assistant professor of Pediatrics at the University of Rochester Medical center and author of the study. "These findings may give us back a tool to help give these fragile babies a better chance of survival."

Before concerns arose in 2000 about safety of multiple courses of steroids, many mothers in on-and-off preterm labor received several rounds before delivering. Now, when mothers go into preterm labor, obstetricians will often administer only a single course of steroids to help strengthen the baby’s lungs upon birth. But if the birth is successfully held off for more than seven days, the mother does not receive another course of medication and the baby’s lungs may not be protected.

This is regrettable, because one of the biggest challenges for babies born preterm is breathing on their own. Many develop respiratory distress syndrome because their lungs have not developed a protective film over their air sacks, called surfactant, which aids in the transfer of oxygen and decreases the work of breathing. Because of that, they may receive medications and supplemental oxygen, which can cause problems of their own.

Some infants develop bronchopulmonary dysplasia, a scarring and inflammation of the lungs, from the oxygen treatment. Others can begin to leak air through the lungs and into the body cavity. Any of these complications, especially coupled with an infection, can be life-threatening.

Previous studies showed neurological complications from multiple courses of dexamet hasone, a steroid prepared with sulfur. However, clinicians do not commonly use that steroid anymore and have largely switched to sulfur-free steroids, such as betamethasone. This study was based on infants who received betamethasone prior to birth, and they did not show the same adverse effects as previous studies.

"Perhaps these babies didn’t react the same way as in other studies because the timing of brain maturation is different. It could also be because these babies received a different kind of steroid that did not contain sulfur," Amin said. "Preliminarily, it looks like we might be able to use multiple courses of steroids, but we need to do more studies to make sure the treatment is safe and effective."

The study, which was performed by analyzing data collected in the University’s neonatal intensive care unit at Golisano Children’s Hospital at Strong between 1996 and 1998, included 174 babies who were born at 28 to 32 weeks. Their brain functioning was measured by a neurological assessment given within 24 hours of birth called the auditory brainstem evoked response (ABR), a non-invasive test that measures the brain’s response to sounds.

"We considered ABR a window into the whole brain," Amin said. "And it doesn’t look like the brain is affected in infants who received multiple courses of betamethasone steroids."

There were no significant differences in the brain’s responses to the testing between the 50 babies who received one course of steroids and the 29 who received two or more courses, even when controlled for gestational age, birth weight, race and exposure to illegal drugs. There were also no significant differences between the 51 infants who received no steroids and those who did. The only medical difference between those infants who received one course and those who received more was that the ones who received more were less likely to need mechanical ventilation the day they were born.

Source-Eu rekalertBR>PRI
'"/>




Related medicine news :

1. Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
2. Multiple organ disease cured by genes
3. Adult stem cells in treatment for Multiple sclerosis (MS)
4. Life Quality For Patients With Multiple Sclerosis
5. Effective Pain Relief For Patients Suffering From Multiple Sclerosis
6. The Link Between Hepatitis B Vaccine And Multiple Sclerosis Questioned
7. Hope For Patients With Multiple Sclerosis
8. Individuals Born In May At A Higher Risk Of Developing Multiple Sclerosis
9. Debating The Link Between Sex Hormones And Multiple Sclerosis
10. Warning Issued by FDA on consumption of the drug Tysabri used to treat Multiple Sclerosis
11. Decreasing Multiple Births By Single Embryo Transfers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/19/2017)... ... 2017 , ... The Lymphoma Research Foundation (LRF) – the ... the lymphoma community through a comprehensive series of education programs, outreach initiatives and ... Swirl: A Wine Tasting Event series on Thursday, October 26, 2017. Hosted at ...
(Date:9/19/2017)... ... 19, 2017 , ... The American College of Lifestyle ... recently formed Corporate Roundtable, a group of individuals and organizations whose collective vision ... Canyon Ranch is a unique collection of lifestyle-based immersion vacation settings and programs ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... ... issued a rallying cry to Americans to watch for the discomforts and hidden ... young athletes to senior citizens, everyone is at risk for developing fungal infections ...
(Date:9/19/2017)... ... September 19, 2017 , ... Leonard I. Linkow, DDS, DMSC, sets ... (published by Xlibris on July of 2014). This book details the recent advances and ... approaches that benefit people who have lost all of their natural teeth . ...
(Date:9/19/2017)... Va (PRWEB) , ... September 19, 2017 , ... The ... the use of health IT to create efficiencies in healthcare information exchange and a ... the release of their latest industry white paper, entitled Barriers to Adoption of ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... , Sept. 5, 2017  Just 18 months ... Insight is pleased to announce the appointment of three ... Tammy Wynne , Dominic Jones-Phillips and ... industry. Tammy ... team of market access writers. She has over ten ...
(Date:9/1/2017)... 2017  Bayer will present the latest research from across ... Oncology (ESMO) 2017 Congress, September 8-12 in Madrid, ... and clinical data on Bayer,s marketed portfolio and late-stage compounds ... "We value the opportunity ... research at ESMO," said Carsten Brunn , Head of ...
(Date:8/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will present at the ... in New York . John Greisch ... present at 11:05 a.m. Eastern Time. The ... A recorded replay will be available one hour after the ... About Hill-Rom Holdings, Inc. ...
Breaking Medicine Technology: