Navigation Links
Mouth Infection better handled with new discovery

Research has proved that a new drug named histatin, a naturally occurring antifungal agent in saliva kills the fungus- Candida albicans,// which is responsible for most HIV-related oral infections.

It is known that candidiasis, also known as thrush, is a disease characterized by whitish spots and ulcers on the membranes of the mouth, tongue and throat. It primarily affects people with weakened immune systems caused by antibiotics, chemotherapy or diseases such as AIDS. Denture wearers may also be affected. It can be treated by antifungal medications in otherwise healthy people, but it is harder to treat in people with compromised immunity and can be deadly if it infects vital organs.

It was known that histatin usually can keep Candida albicans in check among healthy people with enough saliva, but the mechanism of action of the drug was not known.It was discovered through studies that histatin binds to a specific membrane protein called TRK1p, which regulates potassium ion flow through the cell membrane of Candida albicans. This allows the cell to regulate its volume. It is said that the binding action of histatin acts like a foot in the door. Blocking the channel open allows a lethal unregulated flow of potassium and other essential molecules into and out of the cell.

Now that the target for histatin has been identified, a better protein can be designed that will even be more effective in holding the channel open, allowing even better and more rapid killing of the fungus. In addition, many other pathogenic fungi that cause disease in elderly individuals or AIDS patients also should be able to be killed by histatins or drugs designed to target their potassium channels.
'"/>




Page: 1

Related medicine news :

1. Mouthwash as a weapon
2. Mouth wash samples to predict bone marrow transplant results
3. Under Stress? All You Need Is A Chocolate To Melt In Your Mouth
4. Dentists Recommend Kids Use Mouthguard To Protect Them When Doing Sports
5. Drinking, Smoking And Unhealthy Food Linked To Mouth Cancer In Young People
6. Colgate To Develop Anti-Cancer Toothpastes And Mouthwashes
7. Oral Sex Linked To Mouth Cancer Risk
8. Foot and Mouth Disease strikes again in China
9. Foot-And-Mouth Disease of Cattle Reported In Argentina
10. Malaysia Struggles to Control Hand, Foot-and-Mouth Disease In Sarawak
11. Brunei Closes Primary Schools In A Bid To Contain Hand, Foot and Mouth Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: