Navigation Links
Mouth Infection better handled with new discovery

Research has proved that a new drug named histatin, a naturally occurring antifungal agent in saliva kills the fungus- Candida albicans,// which is responsible for most HIV-related oral infections.

It is known that candidiasis, also known as thrush, is a disease characterized by whitish spots and ulcers on the membranes of the mouth, tongue and throat. It primarily affects people with weakened immune systems caused by antibiotics, chemotherapy or diseases such as AIDS. Denture wearers may also be affected. It can be treated by antifungal medications in otherwise healthy people, but it is harder to treat in people with compromised immunity and can be deadly if it infects vital organs.

It was known that histatin usually can keep Candida albicans in check among healthy people with enough saliva, but the mechanism of action of the drug was not known.It was discovered through studies that histatin binds to a specific membrane protein called TRK1p, which regulates potassium ion flow through the cell membrane of Candida albicans. This allows the cell to regulate its volume. It is said that the binding action of histatin acts like a foot in the door. Blocking the channel open allows a lethal unregulated flow of potassium and other essential molecules into and out of the cell.

Now that the target for histatin has been identified, a better protein can be designed that will even be more effective in holding the channel open, allowing even better and more rapid killing of the fungus. In addition, many other pathogenic fungi that cause disease in elderly individuals or AIDS patients also should be able to be killed by histatins or drugs designed to target their potassium channels.
'"/>




Page: 1

Related medicine news :

1. Mouthwash as a weapon
2. Mouth wash samples to predict bone marrow transplant results
3. Under Stress? All You Need Is A Chocolate To Melt In Your Mouth
4. Dentists Recommend Kids Use Mouthguard To Protect Them When Doing Sports
5. Drinking, Smoking And Unhealthy Food Linked To Mouth Cancer In Young People
6. Colgate To Develop Anti-Cancer Toothpastes And Mouthwashes
7. Oral Sex Linked To Mouth Cancer Risk
8. Foot and Mouth Disease strikes again in China
9. Foot-And-Mouth Disease of Cattle Reported In Argentina
10. Malaysia Struggles to Control Hand, Foot-and-Mouth Disease In Sarawak
11. Brunei Closes Primary Schools In A Bid To Contain Hand, Foot and Mouth Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. Josh ... Mesa, and Chandler, Arizona. , Dr. Olson says the decision to support ...
(Date:6/24/2016)... New York (PRWEB) , ... June 24, 2016 , ... ... marijuana patients optimize the ingestion of their medication by matching users with high quality ... users to compare pieces with no commitment. , Inhale was founded by two brothers, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
Breaking Medicine Technology: