Navigation Links
Mouse Study Suggests Anxiety Disorders Take Root in Infancy

The absence of a key signaling protein in the brain during infancy could lead to anxiety disorders later in life, scientists say. //According to findings published today in the journal Nature, mice lacking the receptor protein for the chemical messenger serotonin just after birth exhibit abnormal anxiety as adults.

Researchers have known for some time that mice genetically engineered to lack the receptor for serotonin, a neurotransmitter, show anxiety-like behavior. But the new results go one step further, revealing when in life and where in the brain the link between serotonin receptors and anxiety behavior is forged. As in earlier studies, the investigators, led by René Hen of Columbia University, first created a line of so-called knockout mice that lacked the gene encoding the receptor protein. Those mice showed the expected signs of anxiety, such as moving around less open spaces and taking longer to start eating in new environments as compared with normal animals. To determine which of the two receptor populations--the one in the forebrain or the one in the brainstem--is most critical in that regard, the team then crossed the knockout mice with a line engineered to activate receptor expression in particular brain regions. The resulting line of double-transgenic "rescue" animals expressed the serotonin receptors only in the forebrain, but exhibited normal anxiety behavior. Further tests, in which the drug doxycycline was used to suppress the receptors in mice at various stages of development, showed that eliminating the receptors in juvenile or adult mice did not elicit over-anxiousness.

"Forebrain serotonin receptors are needed during the development of newborns to modulate the predisposition to anxiety-like behavior, but are no longer critical during adult life," Solomon Snyder of Johns Hopkins University explains in a commentary accompanying the report. He proposes that variations in serotonin-sensitive neurons and serotonin receptors early in life might account for the importance of maternal nurturing in preventing emotional disorders later in life. Rats that were not groomed sufficiently as pups by their mothers display elevated levels of anxiety as adults, he notes. "Assuming that we can equate developmental stages in mice and humans," Snyder reflects, "these findings might be relevant to brain development and the genesis of anxiety in people too."

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... December 02, 2016 , ... With the number of ... of an injury, patients must find the one that works for them. When an ... created a machine that worked and decided to share it with others. , He ...
(Date:12/2/2016)... Beverly Hills, CA (PRWEB) , ... December 02, ... ... and reconstructive surgeon in Beverly Hills, California, will be included in the 2016 ... is given to exceptional professionals based on the amalgamation of their education, experience, ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is ... USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that ... “We are prolonging life 6 years in the last 3 decades,” says Dr. ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, offering local frontline clinicians ... of pain management. , The demand for supplemental training related to pain ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs beneath the ... its unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) in addition ... has been available in several ShopRite and FoodTown stores in NJ and received rave ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016  PipelineRx, a leading medication management technology ... demonstrations of its SaaS-based telepharmacy platform, PowerGridRx™ ... 2016 Midyear Clinical Meeting and Exhibition, December 5-7 ... nearly 300 hospital clients nationally, the Company is ... to dramatically improve pharmacy operations, enhance patient safety, ...
(Date:12/2/2016)... Texas , Dec. 2, 2016  Maxor National Pharmacy ... acquisition of Pharmaceutical Specialties, Inc. ("PSI").  The combination of ... Georgia -based PSI bring together both company,s ... physicians, manufacturers, and payers an industry-leading specialty pharmacy. ... , ...
(Date:12/2/2016)... Dec. 2, 2016 Lianluo Smart Limited ... "the Company") which develops, markets and sells medical ... China and international markets, recently ... and Treatment New Progress Forum, co-hosted by the ... Province , Guangdong Provincial People,s Hospital and ...
Breaking Medicine Technology: