( the disease HIBM we are hoping that hu...)Mouse Model Points to Strategy for Treating Rare Muscle Disease & Kidney Disorders,Health

the disease HIBM, we are hoping that humans with the same genetic mutation as in our mouse model will also respond to ManNAc. The availability of these transgenic mice will assist us greatly in assessing the appropriate dosage of the drug to test in HIBM patients.

To date, none of the offspring born to transgenic mice who received ManNAc supplementation have gone on to develop muscle weakness, but the mutant mice remain smaller than their unaffected siblings. Studies are currently ongoing in Dr. Huizings laboratory to study the mutant mice until they reach an older age when researchers can assess any onset of muscle weakness. In addition, NHGRI clinical researchers recently observed a temporary, but significant, improvement in muscle strength among HIBM patients who received intravenous immune globulin G an effect that researchers suspect was mediated through the provision of sialic acid present in the immune globulin.

NHGRI researchers expect the clinical trial of ManNAc for HIBM to begin in late summer or early fall. Based on their findings, the group is also exploring the possibility that ManNAc may benefit people suffering from diseases that involve damage to the cell layers of the kidney that are required for filtering the blood.


'"/>




Page: 1 2 3
Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy