Navigation Links
Mouse Model Beneficial to Study of Head and Neck Cancer

The development of a mouse model by the Oregon Health & Science University Cancer Institute research laboratory has proved beneficial in the study of the often devastating// head and neck squamous cell cancers.

The research was conducted by Xiao-Jing Wang, M.D., Ph.D., and his colleagues. The results of their research breakthrough have been published in the May 15 issue of Genes & Development.

‘This is the first animal model that mimics human head and neck cancer at both the pathological and the molecular levels with 100 percent incidence,’ Wang said.

While scientists have identified some genes involved in head and neck squamous (HNSCC)cell carcinoma , overall, progress has been hampered by the lack of an animal model to study the development and progression of the disease. ‘This model will provide a valuable tool to screen for novel therapeutic and preventive approaches for this often deadly cancer,’ said Wang, head of the Division of Molecular Biology of Head and Neck Cancer in the OHSU School of Medicine and a member of the OHSU Cancer Institute.

Head and neck squamous cell carcinoma is the sixth most common cancer in the United States. It has a low survival rate - fewer than 50 percent of head and neck patients survive beyond five years, and this rate has not changed in the past 20 years, despite progress in developing therapies for other cancers. Patients are usually resistant to routine chemotherapy and radiation therapy. In addition, the quality of life for survivors is usually miserable because the location of the cancer often destroys structures critical to speaking, breathing and swallowing.

In their research, Wang and her colleagues engineered a strain of mice to specifically lack expression of the transforming growth factor beta receptor II (TGFbRII) in epithelial cells of the oral cavity. By then introducing activating mutations in either the H-ras or K-ras (two different isoforms of the Ras GTPase), t he researchers were able to induce invasive HNSCC with 100 percent incidence.

‘Head and neck lesions developed from this mouse model have many molecular alterations similar to those found in HNSCC patients. Additionally, we have identified several new biomarkers that data suggest may be good targets for HNSCC therapy,’ Wang said.

Wang was recruited to OHSU to study head and neck cancers. Through her research and through personal acquaintances, her passion was stirred to help people with this type of disfiguring cancer.

‘Before I came to OHSU, a woman who was helping me here with my new house asked what was bringing me to Portland.

When I told her it was to lead OHSU's research on head and neck cancer, she said, 'Oh, my god, we were meant to meet. My husband was just diagnosed with head and neck cancer.' During my interactions with her after we moved to Portland, I realized how much this disease impacts patients and their family members. Then, only a few months later, a family friend was diagnosed with head and neck cancer. These two cases made me realize that this terrible disease could happen to people all around us, even our loved ones, and inspired me to my best effort in leading this study,’ Wang said.

‘It was a true team effort of the head and neck cancer research division, especially with Dr. Shilong Lu, the first author on this study, who made the major contribution to this model,’ Wang said. Shilong LU, M.D., Ph.D., is research assistant professor of otolaryngology/head and neck surgery in the OHSU School of Medicine.

Peter Andersen, M.D., F.A.C.S., associate professor of otolaryngology/head and neck surgery in the OHSU School of Medicine; and Christopher L. Corless, M.D., professor of pathology in the OHSU School of Medicine, and member of the OHSU Cancer Institute, are co-authors on this study.

Source: Eurealert
'"/>




Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Scientists Discover New RNAs in Mouse Testicles
6. Scientists Isolate Leukemia Stem Cells in Mouse Model
7. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
8. Mouse Gene With Gene Stutter Will Help Leukemia Research
9. Rett Syndrome Reversed in Genetic Mouse Model
10. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
11. Mouse Study Suggests Anxiety Disorders Take Root in Infancy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... to prep patients for colonoscopy at the HyGIeaCare® Center that is to be ... FL. , The HyGIeaCare® Prep, cleared by the U.S. Food and ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate ... during what is often a very difficult and challenging time.” , A Certified ...
(Date:3/24/2017)... ... ... Time GPS”: a dauntless and enlightened study of the second-coming of Christ, and ... published author, Wesley Gerboth, a World War II veteran, with a highly-regarded reputation as ... ninety-one, he shares the Wisdom God bestowed upon him in this publication. , ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... of inspiring stories about real people of God in congregations across the United ... Miller, a Presbyterian minister ordained in 1964 who has served congregations in seven ...
(Date:3/23/2017)... Greensboro, NC & Seattle, WA (PRWEB) , ... March 23, 2017 ... ... international public health emergency and now estimates that there could be four million Zika-related ... fastest growing epidemics to date with numbers of US cases reported per year skyrocketing ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets ... the U.S.: Consumer Strategies" report to their offering. ... Pain ... approach and treat their physical pain, emphasizing consumer survey analysis, ... pain sufferers and adults who have selected illnesses/conditions strongly associated ...
(Date:3/24/2017)... March 24, 2017 ShangPharma, a ... and cost-effective drug development and discovery services, ... biotechnology industry, announced today the intent for ... will be consolidating the Contract Research Organizations ... Shanghai ChemPartner. These entities include ChemPartner Shanghai, ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... offering. ... is very strong with a total of 97 drug candidates. Pharma giant ... are involved in the development of the IPF therapeutics. The IPF pipeline ... stage, 15 are in Phase II stage, 12 are in Phase I ...
Breaking Medicine Technology: