Navigation Links
Mouse Gene With Gene Stutter Will Help Leukemia Research

Cancer researchers have developed a new strain of mice that should help reveal how an unusual change in a certain gene contributes to a particularly deadly form of acute myeloid leukemia (AML).//

A study of the strain by its developers at the Ohio State University Comprehensive Cancer Center (OSUCCC) suggests that the genetic change comes early in the disease, and that it over-activates a second gene that helps govern blood cell development.

The genetic change, known as a partial tandem duplication, is located in a gene called MLL (for mixed-lineage leukemia). A partial tandem duplication is a type of gene mutation that occurs when a section of a gene is repeated, like a stutter in the gene’s DNA.

The new mouse model should help leukemia researchers to learn how this mutation contributes to AML development, and it may lead to new ways to treat, diagnose and perhaps prevent the disease.

The findings were published online Sept. 14 in the Journal of Clinical Investigation.

“When leukemia strikes, it’s like a hurricane arriving without an advance weather forecast – you have no information about how it got there, and it’s a level-5 storm,” says Michael A. Caligiuri, principal investigator of the study and director of the OSUCCC.

“Studying live models like this mouse strain helps us begin to understand the earliest events in the development of leukemia. This in turn will someday allow us to understand what causes leukemia in people, predict who is at greatest risk and prevent leukemia from ever developing in those patients.”

Genes store information for a protein. Mutations can alter the protein, perhaps making it function differently. In this case, the duplication within the MLL gene contributes to an aggressive form of AML. This new study begins to reveal how it does so.

AML will strike an estimated 10,000 Americans this year, and about 45 percent of those will have cancer
'"/>




Page: 1 2 3

Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Rett Syndrome Reversed in Genetic Mouse Model
10. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
11. Mouse Study Suggests Anxiety Disorders Take Root in Infancy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse Gene With Gene Stutter Will Help Leukemia Research

(Date:4/19/2015)... 19, 2015 Family and friends of Brad ... in Memory of Brad Baddeley event to honor his ... , Bowling for Brains is cheduled to take place on ... Street in Lincoln, Nebraska. Participants may arrive at 12:30pm on ... , The cost is only $4 per game and 100% ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Compare-autoinsurance.org has ... a reliable auto insurance policy . , ... Comparing car insurance quotes online is safe and reliable. ... agencies. The quotes are displayed on a single web ... websites. , It is now possible to compare ...
(Date:4/18/2015)... "I recognized the need for a better ... an inventor from Cincinnati, Ohio. "This need inspired me ... the Slyde Door to offer an alternative to the ... provides convenient storage space for an evacuation stretcher. The ... patients. , This offers added peace of mind ...
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog post explaining the ... prices . , Drivers who live in states ... to pay more for auto insurance plans that provide ... offer protection against vehicle theft. , Affordable auto ... single website: http://lowcostcarinsuranceprice.com/ . Drivers who own ...
(Date:4/18/2015)... 2015 In the past few weeks, ... changes. , "We had to run maintenance on our ... said Jennifer Ramirez, the PR Director. "It disrupted our ... that we are back on track after having completed ... of changing phone systems which has not allowed some ...
Breaking Medicine News(10 mins):Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 2Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 3Health News:A Guide For Avoiding Online Auto Insurance Scams! 2Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:TheBeautyPlace.com Temporary Number Available 2
... LAUDERDALE, Fla., Aug. 7 Averaging ... critical 24/7 patient information call center, Hospice Partners On Call ... secure colocation facility, to safeguard its powerful server infrastructure and ... Partners On Call decided to move their back-up servers to ...
... care are needed to close gaps, experts say, , ... extends health coverage to the nation,s 46 million uninsured ... to care -- unless payment reforms and new models ... expanding coverage without reforming health-care delivery is "a recipe ...
... , , DENVER, Aug. 7 ... linking coronary artery disease patients and teams of pharmacists, nurses, primary ... the patients healthy two years after they left the program by ... a randomized study by Kaiser Permanente published in The American Journal ...
... , , , , ... William J. Clinton Foundation, joined Dr. Clyde Yancy, president ... CEO of the Robert Wood Johnson Foundation (RWJF), at the Fourth Annual Healthy ... nation that are transforming into healthier places for students to learn and staff ...
... MECHANICSBURG, Pa., Aug. 7, One trauma center in Pennsylvania has been ... Accreditation for the period from October 1, 2009 through September 30, 2010: , ... York , PA , , ... the Emergency Medical Services Act (Act 1985-45). The PTSF is the organization ...
... OAK BROOK, Ill., Aug. 7 / PRNewswire / -- ... a multi-year partnership with the National Association of Ticket Brokers (NATB) that ... States and volunteerism by members of the NATB family. As of ... tickets to their local RMHC Chapters. , , ...
Cached Medicine News:Health News:Hospice Partners On Call Selects Category 5 Hurricane Rated 1Vault Networks to Safeguard Server and Call Center Infrastructure 2Health News:Expanding Health Coverage May Not Improve Access 2Health News:Expanding Health Coverage May Not Improve Access 3Health News:Electronic Health Records Help Cardiac Patients Remain Healthy 2Health News:Electronic Health Records Help Cardiac Patients Remain Healthy 3Health News:Electronic Health Records Help Cardiac Patients Remain Healthy 4Health News:More Than 100 Healthy Schools Honored by the Alliance for a Healthier Generation 2Health News:More Than 100 Healthy Schools Honored by the Alliance for a Healthier Generation 3Health News:More Than 100 Healthy Schools Honored by the Alliance for a Healthier Generation 4Health News:More Than 100 Healthy Schools Honored by the Alliance for a Healthier Generation 5Health News:York Hospital Trauma Center Upgrade 2Health News:NATB Announces Partnership With Ronald McDonald House Charities(R) 2Health News:NATB Announces Partnership With Ronald McDonald House Charities(R) 3
(Date:4/17/2015)...  AbbVie Inc. ("AbbVie") (NYSE / CHX / Euronext Paris ... expiration of its exchange offer to acquire all of the ... p.m., New York City time, on ... AbbVie also voluntarily withdrew its initial Notification and Report Form ... the FTC with additional time to review the proposed transaction.  ...
(Date:4/17/2015)... April 17, 2015 Nonin Medical, a global ... and Chief Operating Officer Steve Bucholz will ... is expanding his role as Chief Executive Officer. In ... Chief Technology Officer. Operations will transition to David ... Bucholz has been instrumental to Nonin Medical,s growth," ...
(Date:4/17/2015)... 2015 Research and Markets ( ... "Medical Device Outsourcing - Global Strategic Business ... This report analyzes the worldwide markets for Medical ... Device Categories: Class I, Class II, and Class ... report Include - Radiology, Orthopedic, Neurology, Cardiology, and ...
Breaking Medicine Technology:AbbVie Extends Exchange Offer to Acquire Pharmacyclics, Inc. 2AbbVie Extends Exchange Offer to Acquire Pharmacyclics, Inc. 3AbbVie Extends Exchange Offer to Acquire Pharmacyclics, Inc. 4Nonin Medical's Philip Isaacson Expands CEO Role; President and COO Steve Bucholz to Retire May 1 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3
... Olympus is proud to announce the next ... a good thing even better.,Now you have ... The CYF-4 and CYF-4A feature improved optics, ... smoother insertion of instruments. In addition, the ...
... Thermotherapy™ is an advanced transurethral microwave ... of benign prostate hyperplasia (BPH). TherMatrx ... BPH thermotherapy treatment in the United ... TherMatrx does not require cutting, heavy ...
... release of the OES Pro line of One-Piece ... commonly used cystoscopy sheaths has taken Olympus Rigid ... have one instrument that performs it all. Thanks ... offer a superior channel size while maintaining the ...
Fast, accurate SpO2 measurements always within reach....
Medicine Products: