Navigation Links
Morphine Withdrawal Complicates Hepatitis C Infection in Drug Abusers

Hepatitis C, a condition that leads to inflammation of the liver is common among intravenous drug users. There are nearly 70-80 % of abusers are suffering from // the disease in the United States.

This high association has generated interest in determining the effects of drug abuse, specifically opiates, on progression of the disease. The discovery of such an association would impact treatment of both HCV infection and drug abuse. It has now been established from a recent study that morphine withdrawal complicates the Hepatitis C infection by suppressing IFN-alpha-mediated immunity and enhancing virus replication.

It has previously been shown using cell culture techniques that morphine enhances virus replication and inhibits IFN-alpha (a natural anti-viral factor produced by immune, as well as host cells, and the only one approved in recombinant form for treating HCV infection).

The researchers examined the effects of morphine withdrawal (MW) on HCV-infected cultured liver cells by exposing cells to the drug for four days followed by its removal. They also assessed the effects of using naloxone.

To measure HCV replication, they used a virus-like “replicon” that mimics the events that occur in liver cells. Although the replicon does not produce the infectious virus, the HCV replicon system represents the best available system for examining the impact of opiates on HCV at the time of the study.

It was found that there was an increase in the number of HCV replicon in both the withdrawal scenario. Furthermore, there was an inhibition of the IFN-alpha expression in liver cells in the presence or absence of HCV replicon in both the cases.

Since IFN-alpha is a critical self-defense mechanism utilized by liver cells to fight off viral infection, including HIV, this study suggests that morphine withdrawal weakens host cell immunity and provides a favorable environment for HCV growth in the liver. The s tudy also throws light on explaining why so many HCV-infected patients fail to respond to IFN-alpha treatment.

These results suggest that opioid abusers experiencing periods of drug abuse, followed by periods of withdrawal (due to lack of supplies) may lead to immunocompromised liver. The study also underscores the necessity of future clinical and epidemiological studies to define the role of opiate abuse in promoting HCV disease. These findings further support the need for methadone maintenance treatment as an additional benefit for opioid abusers.
'"/>




Related medicine news :

1. Morphine may excite cancerous tumors
2. Using Morphine to Hasten Death Is a Myth, Says Doctor
3. How Morphine Affects Memory
4. Withdrawal Notice Issued For Older Pacemakers Due To Malfunctioning of the Device
5. Hospital Services Still Paralysed Inspite Of The Withdrawal Of The Strike
6. Risk Of Death Increases With Sudden Withdrawal Of Medications
7. Sudden Opioid Withdrawal Results in ‘Broken Heart Syndrome
8. Cadbury Dismisses Rumors of Withdrawal of More Products
9. Andhra Wants Withdrawal of Warning Signal from ‘Beedi’ Packes
10. HIV Testing Improves After Withdrawal of Consent Letter
11. FDA Announces Voluntary Withdrawal of Pergolide Products
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... 19, 2017 , ... Creative messages to prevent distracted driving ... Impact Teen Drivers and California Casualty. Entries from students aged 14-22 can be ... $15,000 will be awarded for the best peer-to-peer messages sharing solutions to reckless ...
(Date:1/19/2017)... ... January 18, 2017 , ... The CHP suggests that California drivers can avoid ... slowing down and increasing the space between themselves and other vehicles, according to a ... attorney Raymond R. Hassanlou notes that, rain or shine, drivers should always incorporate safe ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Connecticut Dermatology Group ... Kim, a highly experienced and compassionate dermatologist. Dr. Kim brings an extensive background ... , “It is with considerable pleasure to welcome back Dr. Kim to the CDG ...
(Date:1/19/2017)... ... January 19, 2017 , ... Sales Focus Inc. (SFI), a ... the US market. , Over the past 20 years SFI has been recognized as ... has launched six new clients into the US market. The new clients include: ...
(Date:1/19/2017)... ... January 19, 2017 , ... Infinity® Massage Chairs announced today that Dan ... sales and marketing strategies. Grover comes with a total of 15 years experience in ... years as Executive Vice President of Direct Sales at Traeger® Wood Pellet Grills. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... January 19, 2017 According to a study ... is set to witness a CAGR of 6.5% during the forecast ... will continue to be the leading market for cryotherapy globally ... ... emphasizing on ensuring affordable and adequate supply of gas in order ...
(Date:1/19/2017)... 19, 2017 ViewRay, Inc. (Nasdaq: VRAY) announced today ... supporting research in Germany , has ... at the University Clinic Heidelberg as part of its ... Linac program will be headed by Medical Director and ... oncology at the German Cancer Research Center (DKFZ), the ...
(Date:1/19/2017)... , January 19, 2017 ... administration appears serious about reducing the FDA,s regulatory ... innovation in the medical drug industry, many of ... with new clinical trials and development of advanced ... forging ahead with recent developments include:  Moleculin Biotech, ...
Breaking Medicine Technology: