Navigation Links
Morphine Withdrawal Complicates Hepatitis C Infection in Drug Abusers

Hepatitis C, a condition that leads to inflammation of the liver is common among intravenous drug users. There are nearly 70-80 % of abusers are suffering from // the disease in the United States.

This high association has generated interest in determining the effects of drug abuse, specifically opiates, on progression of the disease. The discovery of such an association would impact treatment of both HCV infection and drug abuse. It has now been established from a recent study that morphine withdrawal complicates the Hepatitis C infection by suppressing IFN-alpha-mediated immunity and enhancing virus replication.

It has previously been shown using cell culture techniques that morphine enhances virus replication and inhibits IFN-alpha (a natural anti-viral factor produced by immune, as well as host cells, and the only one approved in recombinant form for treating HCV infection).

The researchers examined the effects of morphine withdrawal (MW) on HCV-infected cultured liver cells by exposing cells to the drug for four days followed by its removal. They also assessed the effects of using naloxone.

To measure HCV replication, they used a virus-like “replicon” that mimics the events that occur in liver cells. Although the replicon does not produce the infectious virus, the HCV replicon system represents the best available system for examining the impact of opiates on HCV at the time of the study.

It was found that there was an increase in the number of HCV replicon in both the withdrawal scenario. Furthermore, there was an inhibition of the IFN-alpha expression in liver cells in the presence or absence of HCV replicon in both the cases.

Since IFN-alpha is a critical self-defense mechanism utilized by liver cells to fight off viral infection, including HIV, this study suggests that morphine withdrawal weakens host cell immunity and provides a favorable environment for HCV growth in the liver. The s
'"/>




Page: 1 2

Related medicine news :

1. Morphine may excite cancerous tumors
2. Using Morphine to Hasten Death Is a Myth, Says Doctor
3. How Morphine Affects Memory
4. Withdrawal Notice Issued For Older Pacemakers Due To Malfunctioning of the Device
5. Hospital Services Still Paralysed Inspite Of The Withdrawal Of The Strike
6. Risk Of Death Increases With Sudden Withdrawal Of Medications
7. Sudden Opioid Withdrawal Results in ‘Broken Heart Syndrome
8. Cadbury Dismisses Rumors of Withdrawal of More Products
9. Andhra Wants Withdrawal of Warning Signal from ‘Beedi’ Packes
10. HIV Testing Improves After Withdrawal of Consent Letter
11. FDA Announces Voluntary Withdrawal of Pergolide Products
Post Your Comments:
(Date:8/23/2014)... Pixel Film Studios, a leader of Final Cut Pro ... Vol.3, a customizable title tool for FCPX , ... dragging ProIntro Vol.3 in their timeline" says Christina Austin, CEO ... saver and i think our users will agree" , ProIntro ... made with Final Cut Pro X users in mind. Achieve ...
(Date:8/23/2014)... 23, 2014 Youth substance abuse is ... no different in Houston, TX. Substance abuse can happen ... to drug and alcohol dependency in higher numbers than ... beat substance abuse, but don’t know where to find ... can be a challenge because most treatment options are ...
(Date:8/23/2014)... 2014 Summer vacation is almost over and ... in session. While shopping for school supplies and a new ... encourages parents and students to also spend some time brushing ... excellent hitchhikers and thrive in heavily populated places,” said Randy ... and dorms the perfect settings for bed bugs to take ...
(Date:8/22/2014)... August 23, 2014 2014 Deep ... a professional and in-depth research report on the ... Meter information, including Glucose Meter definition, classification, application, ... overview. This research covers the international market analysis, ... analysis covering macroeconomic environment & economic situation analysis. ...
(Date:8/22/2014)... Today, Zane Benefits, the #1 Online Health ... Plans. , According to Zane Benefits, employers are adopting ... the cost of healthcare without reducing coverage for employees. ... can be confusing. , The new guide contains a ... types of ABHPs. It also explains the similarities, ...
Breaking Medicine News(10 mins):Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:Expert Advice for a Bed Bug-Free School Year 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3
... News) -- "Team-based care" should be used to improve ... Community Preventive Services recommended on Tuesday. The recommendation ... showed improvements in patients, control of blood pressure when ... -- a primary care doctor supported by a pharmacist, ...
... who undergo one of the most common treatments for ... according to new research by Henry Ford Hospital. ... level of the surgeon doing the procedure mattered somewhat ... on data gathered throughout the U.S., will be presented ...
... Rice University freshmen took a mousetrap and built a better ... "The goal was to regulate the amount of fluid ... said Melissa Yuan, a member of the IV DRIP (Dehydrated ... designed to be used in severely underdeveloped parts of the ...
... HealthDay Reporter , TUESDAY, May 15 (HealthDay News) ... arteries, it may not be useful to give them ... symptoms such as chest pain or shortness of breath, ... populations of post-angioplasty and post-bypass patients; screening asymptomatic patients ...
... 15, 2012) - Beta-carotene, selenium and folic acid taken ... are probably harmless. But taken at much higher levels as ... proven to increase the risk of developing a host of ... they,re essential and we need them, but we need them ...
... recent research released in June,s Journal of Thoracic Oncology ... the lungs might be an additional predictive technique for lung ... found that 96.4 percent of the positive CT screening results ... more accurately diagnose patients. This research focused on a way ...
Cached Medicine News:Health News:U.S. Task Force Issues Blood Pressure Guidelines 2Health News:Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery 2Health News:This 'mousetrap' may save lives 2Health News:Are Post-Angioplasty Stress Tests Unnecessary? 2
(Date:8/21/2014)... 2014  Aptuit LLC announces that Aptuit SSCI, ... , has enhanced its capabilities in the areas ... large molecules, including biologic drugs, metabolites, and polymers, ... mass spectrometer. In making the announcement, ... "The expanded large molecule capability enhances our early ...
(Date:8/21/2014)... Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... cancers and women,s health, has appointed Holly B. ... Markets. Ms. Bauzon has a proven track ... coverage for laboratory services companies. She has more than ... Inc., where she held the position of Director, Lab ...
(Date:8/21/2014)... 21, 2014  eRelevance Corporation ( www.erelevancecorp.com ), ... that it has completed integration with Nextech, a ... Surgery and Dermatology practices. "Integration allows ... healthcare practices using Nextech," stated Bob Fabbio ... information from the EMR we are able to ...
Breaking Medicine Technology:Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2
... , FORT COLLINS, Colo., Dec. 14 Manchester Pharmaceuticals, ... (chenodiol tablets). On October 22, 2009, the US ... therapy for patients suffering from gallstones in whom surgery ... advanced age. , Chenodal prescriptions have started to be ...
... 14 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: OXBT) today ... the addition of Lt. Gen. Ronald R. Blanck, DO, U.S. ... Associates, a federal health services consulting firm based in Falls ... nine members. , Dr. Blanck began his military career in ...
Cached Medicine Technology:Manchester Announces Availability of Chenodal(TM) 2Oxygen Biotherapeutics, Inc. Expands Board of Directors 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: