r of hormones, which may affect the physiology of the breast," said Jaworowicz.
"We were interested in the association between pregnancy-related events and characteristics, including pregnancy-induced hypertension, preeclampsia/eclampsia, gestational diabetes, high weight gain during pregnancy, and nausea and vomiting, because these markers may serve as proxies for underlying hormonal changes and altered hormone levels in blood and tissue," he added.
Jaworowicz noted that the presence or absence of these pregnancy-related conditions may indicate a different course or extent of hormone-regulated breast tissue proliferation and differentiation during pregnancy, but also may indicate distinct hormonal profiles that persist following pregnancy.
Evidence from the current analysis did suggest that the lower risk of developing breast cancer observed with nausea and vomiting was stronger as the symptoms became more severe, or persisted longer into pregnancy.
"Pregnancy is a time of drastic physiological changes, including rapid development and alterations in the breast tissue. The rapidly changing anatomy of the breast makes it more susceptible to errors in DNA replication and/or repair, which may translate into breast cancer," he said.
"Associated with these changes are the fluctuating hormonal profiles that must be kept in a delicate balance. If the correct ratios and relative amounts between these hormones are not maintained within a normal range, certain pregnancy-related outcomes may emerge, such as high blood pressure, glucose intolerance and gestational diabetes, eclamptic conditions with seizures and/or toxemia, or extremely severe nausea.
"These pregnancy-related factors may serve as indicators of underlying biological conditions that may influence a woman's lifetime risk for breast cancer," he added.
The study and its results were presented at the Society for EpidemioPage: 1 2 3 Related medicine news :1
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