protocols, it adapted this technique to include the quantitation of cholesterol oxidation products in the same sample.

Halliwell's team found that zinc supplementation did not have a significant impact on the increase in total blood cholesterol levels in animals fed high cholesterol, but it did seem to significantly reduce the accumulation of total cholesterol levels on arterial walls.

In the cholesterol diet group cholesterol concentration levels were seen to be around 11.5 mg/g tissue, compared to around 4.5 mg/g tissue in the cholesterol diet plus zinc group.

Average aortic lesion cross-sectional areas were around 3mm2 in the cholesterol diet group, but only around 1.5mm2 in the cholesterol diet plus zinc group.

They also observed that elevated levels of cholesterol oxidation products (5,6-alpha and beta cholesterol epoxides, 7beta-hydroxycholesterol, 7-ketocholesterol) in aorta.

Total F(2)-isoprostanes in plasma of the rabbits that were fed a cholesterol diet were around 1.7 mg/ml in the cholesterol plus zinc group – on a par with the control group – compared to around 5.3 ng/ml in the cholesterol diet only group.

Likewise with total F(2)-isoprostane content in tissue, the cholesterol plus zinc group and control group had around 3.3ng/ml, compared to around 5ng/ml in the control group.

“Our data indicate that zinc has an anti-atherogenic effect, possibly due to a reduction in iron-catalyzed free radical reactions,” wrote the researchers.

“Since some groups of the population have deficient dietary intake or lower tissue levels of zinc reasonable supplementation of zinc in the diet of humans at risk of atherosclerosis should be considered as a strong candidate for further clinical investigation.”

However they said that the mechanism of action is still unclear, despite several studies demonstrating that zinc supplementation can reduce oxidative damag
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