Navigation Links
More Mutations Of Gene That Cause Skin Disorders And Asthma Discovered

Scientists have zeroed in on 15 more mutations of the gene responsible for the debilitating disorders eczema and asthma, in children. //

The study claims to make treatment more specific for ethnic groups as well as pinpoint various forms of the gene’s effects by genetic tests.

Says Irwin McLean at the College of Medicine, Dentistry and Nursing at the University of Dundee, who led the study:” Once we cracked this exceptionally difficult gene, we were surprised to learn how many different defects in filaggrin were waiting to be discovered, not only in European people, but other populations worldwide."

Last year the team had discovered that the mutated gene, which is carried by five million people in Britain, produced a protein called filaggrin, which brings about inflamed skin.

At present the latest research has shown five of these mutations are prevalent in European patients with 9 percent of the population believed to carry the defect. It was seen that two of these mutations were prevalent in those tested from Oriental backgrounds.

Eczema is known to affect around one in five UK children. Knowing which mutations to look for could allow doctors to identify individuals at risk of the disease early on. It might also allow scientists to develop treatments.

Until filaggrin's role was identified, researchers had mostly assumed that problems with the immune system were responsible for the condition. At present, research is focusing on drugs that can boost production of the filaggrin protein in skin.

Filaggrin, which is normally found in the outer layers of the skin, provides a preventative barrier. In the mutated genes filaggrin is missing which causes inflammation.

The researchers searched through filaggrin sequences in 23 sufferers from Ireland, Scotland, the Netherlands and Austria in order to find out the genetic errors that cause these disorders.

This search threw u p 12 changes to the normal sequence that prevented or reduced protein production from the gene. A further study of five Irish children with severe eczema identified three more mutations.

When the team looked at 188 Irish children with eczema they found that around half carried at least one mutation in the filaggrin gene that would prevent production of the protein. The study is published in the journal Nature Genetics.

Mutations to the filaggrin genes, which come in pairs, are thought to damage the outer layers of the skin, allowing the entry of allergens, which drive the immune system haywire.

A mutation to one gene is enough to cause ichthyosis vulgaris, a dry, scaly skin. If both genes are faulty, the problems lead to eczema, asthma, and, it is suspected, hayfever and peanut allergy.

The researchers hope that the study findings will lead to more effective treatments and preventative measures in babies.

Allergic conditions such as eczema, hayfever and food intolerances have increased dramatically. Almost half of the UK population is thought to have some form of allergy.


Related medicine news :

1. Stem Cells Have Few Mutations
2. Mutations in NOTCH1 cause an early developmental defect in the aortic valve
3. Developing Countries Undertake Cataloguing of Human Mutations
4. Gene Mutations Causing Rett Syndrome Occur in Both Sexes
5. New Technique Identifies Unknown Genetic Mutations That Can Cause Cancer
6. Scinetists Alert to Onset of Pandemic through Bird flu Mutations to Humans
7. Certain Gene Mutations Numbs Pain
8. Genetic Mutations - Key to Autism ?
9. Cancer Gene Mutations Not Uncommon in General Population
10. Computer Tool Helps Pinpoint Risky Gene Mutations
11. Gene Mutations Behind Fidgety Kids: German Scientists
Post Your Comments:

(Date:10/12/2015)... ... ... to an article published October 6th by the Herald Tribune, a recent study ... taken in 1988 has shown that it really is more difficult to lose weight these ... someone in 1971 would be on average 10 pounds heavier than their past counterpart. In ...
(Date:10/12/2015)... ... October 12, 2015 , ... ... 19, 2015, high school aged female athletes, particularly in the area of track ... motion and mechanical overuse injuries than male peers in the same age group. ...
(Date:10/12/2015)... ... October 12, 2015 , ... According to an article published September ... an efficient way to save money on the healthcare needs of patients across the ... patients, house call visits can often effectively eliminate the need to go in and ...
(Date:10/12/2015)... ... October 12, 2015 , ... According to an article published ... San Antonio, Texas recommended that any high-rises in the city limits that do not ... forward. The article explains that it wasn’t until 1982 that the city started requiring ...
(Date:10/12/2015)... , ... October 12, 2015 , ... The Horizon Foundation ... initiatives focused on improving public health and enhancing the quality of life in the ... to 11 New Jersey non-profit organizations. , The charitable arm of Horizon Blue ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... , Oct. 12, 2015 Zimmer Biomet ... third quarter 2015 sales and earnings conference call will ... 29, 2015, at 8 a.m. Eastern Time.  A news ... at 7:30 a.m. Eastern Time the morning of the ... archived for replay following the conference call. --> ...
(Date:10/12/2015)... PARK, Calif. , Oct. 12, 2015 ... R&D and Chief Scientific Officer of Asterias ... biotechnology company in the emerging field of ... Dealmakers webcast, sponsored in part by Asterias ... Dr. Lebkowski will discuss the progress to ...
(Date:10/12/2015)... , Oct. 12, 2015 This study focuses ... and company profiles. In the two past decades, the industry ... of the manufacturing capabilities and rising consumer consumptions in ... society and economy. China is ... products. Far outpacing other economies in the world, ...
Breaking Medicine Technology: