( t exist anywhere else. This was discove...)Monoclonal Antibody based system for Anthrax detection,Health

t exist anywhere else. This was discovered by Seerberger and his team.

Since it was very difficult to isolate that particular sugar from the deadly bacterium, Seeberger and his team thus chose an alternative route: they synthesized the carbohydrate in the laboratory, attached it to a special "carrier" protein and injected this compound into mice.

Usually, carbohydrate antigens bring about weak immunological reaction whereas, this carrier protein stimulated a stable one. Monclonal antibodies were produces and isolated from these immunized mice. These antibodies bound exclusively to the surface molecule of Bacillus anthracis. They did not bind to other bacteria closely related to B. anthracis. Seeberger hoped that a highly sensitive anthrax diagnostic system and new vaccines would be based on this new antibody.

"I think it would be very useful and it could be important for testing against biowarfare," said Seeberger. “The system could be used by the authorities, post offices and medics responding to potential anthrax threats, as well as by armies in the field”, he added.

Seeberger said that it would take 6 months to incorporate these antibodies into the existing systems. Discussions with interested companies were in progress, he said.He hoped for the further development work to be done in Switzerland but it might be done in the United States.

Bacillus anthracis causes the infectious disease Anthrax which usually infects wild and domestic animals such as goats and sheep. Humans can be affected in 3 ways: inhalation of anthrax spores, by eating infected meat that has not been properly cooked and by skin absorption.

"Our results demonstrate that small differences in the carbohydrates on cell surfaces can be used to obtain specific immune reagents," says Seeberger. "Our new antibodies will be used as the basis for highly sensitive anthrax diagnosis and will contribute to the development of new therapeutic approa
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