Navigation Links
Monoclonal Antibody Reduces Exacerbations in Asthmatics

Patients with symptomatic moderate asthma who were treated with anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly// fewer disease exacerbations than individuals taking a placebo.

This research appears in the first issue for October 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Trevor T. Hansel, M.D., Ph.D., of the National Heart and Lung Institute at Royal Brompton Hospital in London, and 11 associates infused 14 patients with infliximab, a monoclonal antibody that binds and neutralizes tumor necrosis factor alpha (TNF?). Eighteen patients received placebo during the eight-week double-blind study.

According to the investigators, both structured and inflammatory cells in asthmatics can release TNF?, which is an intercellular messenger protein, a cytokine, produced by white blood cells.

“Anti-TNF? therapy has been shown to be effective in patients with rheumatoid arthritis, ankylosing spondylitis, Crohn’s disease and psoriasis, but ineffective in patients with chronic obstructive pulmonary disease (COPD),” said Dr. Hansel. “Preliminary reports of efficacy in asthma patients with concomitant rheumatoid arthritis have been encouraging. Small prospective studies of a soluble receptor directed against TNF? in severe refractory asthma have also shown improvements in lung function and airway hyperresponsiveness.”

During the study, 13 of the 18 patients on placebo (72 percent) experienced exacerbations, as compared to only four out of 14 patients (29 percent) on infliximab therapy.

All patients in the study cohort continued to use inhaled corticosteroids for their asthma. Study protocol required them to be symptomatic during a two- to four-week run-in period.

After the run-in phase, infusions of either infliximab or placebo were administered at weeks zero, two and six.

“Treatment with infliximab reduced the number of moderate exacerbations in patients with asthma, as monitored by morning and evening use of an electronic spirometer incorporating a clinical diary,” said Dr. Hansel. “Although infliximab therapy did not show significant efficacy for the primary endpoint of monitoring peak expiratory flow (PEF), it did produce a significant decrease in the diurnal (during the day) variation in the PEF rate.”

(With PEF monitoring, patients take as deep as a breath as possible, then exhale as forcefully as possible into the mouthpiece of the PEF meter for three tests. As a gauge for pulmonary function, it is especially useful in patients older than age five who have persistent moderate to severe asthma.)

“None of the exacerbations we saw in our study warranted treatment with oral corticosteroids or hospitalization, so they cannot be considered to have been severe,” said Dr. Hansel.

The researchers noted there were no adverse events associated with using the monoclonal antibody for treatment.

“Given that infliximab therapy was well-tolerated and appeared to reduce the incidence of asthma exacerbations, anti-TNF? therapy merits further study in larger clinical trials in patients with severe asthma,” concluded Dr. Hansel.

Source-Newwise
SRM
'"/>




Related medicine news :

1. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
2. Monoclonal antibodies show promise in treatment of blood cancer
3. Monoclonal Anti-Body To Revolutionize Brain Cancer Treatment
4. Monoclonal Antibody based system for Anthrax detection
5. Survival of Mice With Human Breast Cancer Extended by Monoclonal Antibodies
6. Human Antibody That Can Block SARS
7. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
8. Cuba Registers New Antibody
9. Single Sugar Enables Antibody to Treat Inflammation
10. Monoclonal Antibody based system for Anthrax detection
11. Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2017)... ... , ... Leading dental clinicians, Drs. Ashlyn Price, Autumn Mayers and Ron Adelman, ... systems. With advanced digital images and modeling capabilities, the dentists identify all of the ... oral health for those who are missing teeth in Midlothian, VA. , ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants in the ... finding product improvements that could reduce the occurrence of unplanned extubations (UEs). ... breathing or to provide medication. Sometimes, patient movement can cause unplanned extubations which ...
(Date:6/20/2017)... ... June 20, 2017 , ... BrightStar Care Centerville/South Dayton, a ... the Joint Commission, which accredits and certifies nearly 21,000 healthcare organizations and programs ... a symbol of quality that reflects an organization’s commitment to meeting certain performance ...
(Date:6/20/2017)... ... June 20, 2017 , ... The law firm of ... installation as the president of the DuPage County Bar Association’s Board of Directors. Cassioppi ... June 9 at the Drake in Oak Brook. Momkus McCluskey Roberts LLC attorney Stacey ...
(Date:6/19/2017)... ... 19, 2017 , ... Intrinsic Clinical Systems announced it will ... actionable insights to improve health globally through the advancement of lifesaving medicines and ... faster, easier, and less painful. Attendees can visit Intrinsic’s booth showcasing its four ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away with ... platform is described by Forbes as "entering the life ... Medical Association as teaching "empathy to medical professionals in ... startup was recently named a finalist for the Department ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
(Date:6/7/2017)... June 7, 2017 Endo International plc (NASDAQ: ... 2017, the Hon. Joseph R. Goodwin , U.S. ... West Virginia , entered a case management ... Repair System Products Liability Litigation (the "MDL") that includes ... to provide expert disclosures on specific causation within one ...
Breaking Medicine Technology: