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Monoclonal Antibody Induces Death in Liver Cancer Cells

lls in culture.

When both human and mouse live cancer cell lines were treated with a monoclonal antibody, tumour cell proliferation significantly decreased and programmed cell death (apoptosis) increased four to 18 fold, as compared to normal control cells.

The researchers say that the results depict PDGFRa as a possible new therapeutic target for the treatment of HCC.

"We are very excited because this is the first targeted therapy for liver cancer. Other therapies have some modest benefits, but no one knows exactly how they work. We now have identified a pathway that appears to be overly active in more than 70 per cent of the cancers we examined and, when targeted, leads to significant reduction in tumour cell proliferation and survival," said Dr. Monga.

He also says that targeting the PDGFRa pathway in liver cancer cells does not affect normal liver cells, making the treatment relatively non-toxic.

"Normally, regenerating liver cells are not exclusively dependent on this pathway, and it is not overly active in other types of cells. So this monoclonal antibody is a highly targeted treatment for this disease," he added.


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