Navigation Links
Monoclonal Anti-Body To Revolutionize Brain Cancer Treatment

The use of monoclonal anti-body (mAb) L2G7 could revolutionize treatment of Glioma, the most common type of primary brain tumor. Surgery, chemotherapy and radiation are the only available treatment options for this type of cancer. // However, there is a significant risk of physical inability and cognitive impairment associated with these treatment forms. The results of the study can be found in the Clinical Cancer Research journal.

The anti-body was found to inhibit growth of the malignant glioma cells, inducing an attenuation of growth. Surprisingly, the survival rate was also extended. Following these promising findings, it is hoped that human clinical trials of the immunotherapy would be initiated soon.

Animal models (mice) were created to represent human models of the malignant disease by Dr. Jin Kim (Galaxy Biotech) and Dr. John Laterra (Kennedy Krieger Institute). A study was then devised to test the effectiveness and safety of the monoclonal anti-body in the glioma treatment. Implantation of L2G7 under the skin was found to produce complete inhibition of the tumor while better results (tumor inhibition, tumor regression and enhanced survival rate) were seen following implantation in the brain.

The novel monoclonal anti-body, developed by Dr. Kim and his research team targeted the inhibition of hepatocyte growth factor (HGF), believed to play a major role in the further growth and spread of cancer by accelerating cell division, inducing formation of blood vessels and increasing resistance to chemotherapy drugs. The successful incorporation of the antibody, surpassing the 'blood-brain barrier' (BBB) proved to be a challenging task for the researchers.

Mice were treated with either L2G7 or a placebo, the results of which turned to be in favor of the monoclonal antibody, probably due to its specificity. The main advantage of this treatment modality is that it minimizes chances of neighboring tissue damage and the side effects.

Brain tumors account for significant mortality in children below 20 years of age. Conventional therapies have a very limited role to play in the treatment of brain tumors. The researchers have expressed hope over extrapolating the above finding which has already been proved successful in the treatment of lung, breast and colon cancer.


'"/>




Related medicine news :

1. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
2. Monoclonal antibodies show promise in treatment of blood cancer
3. Monoclonal Antibody based system for Anthrax detection
4. Monoclonal Antibody Reduces Exacerbations in Asthmatics
5. Survival of Mice With Human Breast Cancer Extended by Monoclonal Antibodies
6. Complete Robotic Surgery To Revolutionize Surgical Treatment of Prostate Cancer
7. LINK Applied Genomics Programme Promises To Revolutionize Healthcare Systems
8. Heart Stem Cells Could Revolutionize Cardiac Disease Therapy
9. Bio-Functional Garments That Could Revolutionize Fashion Industry
10. New Technique Could Revolutionize Melanoma Diagnosis and Treatment
11. Azathioprine Can Soon Revolutionize Eczema Treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... CA (PRWEB) , ... February 08, 2016 , ... ... showing greater than 50% lower incidence rate of type 2 diabetes in the ... averages. ”It is time to make a change in public health,” states Carole ...
(Date:2/8/2016)... Vegas, Nevada (PRWEB) , ... February 08, 2016 ... ... at RowdMap, Inc., will be speaking on how healthcare companies can use newly ... costs, manage the health of a population and intervene and capture the value ...
(Date:2/8/2016)... ... February 08, 2016 , ... According to ... the U.S. require dental technicians to be certified or obtain continuing education. To ... created the “What’s In Your Mouth?” campaign to inform dentists and patients about ...
(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart Holdings, Inc. announced ... with the tools and information to lower the costs, and increase the impact ... of providing employee healthcare benefits by as much as 22%:, + Price ...
(Date:2/6/2016)... (PRWEB) , ... February 06, 2016 , ... US Sports ... Coaching Conference (YUCC) . This event brings together top non-profit leaders, ultimate organizations, and ... and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and Education, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb.8, 2016 Aesthetic Devices - Medical Devices ... sector report, "Aesthetic Devices - Medical Devices Pipeline Assessment, ... pipeline stage. This report is prepared ... research by GlobalData,s team of industry experts. *Note: ... altered based on the availability and relevance of data ...
(Date:2/8/2016)... 2016  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... quarter and year-end 2015 results after the Nasdaq market ... host a live conference call and webcast to discuss ... afternoon, February 11, 2016 at 4:30 p.m. Eastern Time ... --> http://www.neurocrine.com . --> Participants can ...
(Date:2/8/2016)... --  GS1 US will hold a series of ... Standards implementation to address the requirements of the U.S. ... rule. Scott Brown , director of ... director industry development, medical devices, GS1 US; and ... --> Scott Brown , director of ...
Breaking Medicine Technology: