Navigation Links
Monoclonal Anti-Body To Revolutionize Brain Cancer Treatment

The use of monoclonal anti-body (mAb) L2G7 could revolutionize treatment of Glioma, the most common type of primary brain tumor. Surgery, chemotherapy and radiation are the only available treatment options for this type of cancer. // However, there is a significant risk of physical inability and cognitive impairment associated with these treatment forms. The results of the study can be found in the Clinical Cancer Research journal.

The anti-body was found to inhibit growth of the malignant glioma cells, inducing an attenuation of growth. Surprisingly, the survival rate was also extended. Following these promising findings, it is hoped that human clinical trials of the immunotherapy would be initiated soon.

Animal models (mice) were created to represent human models of the malignant disease by Dr. Jin Kim (Galaxy Biotech) and Dr. John Laterra (Kennedy Krieger Institute). A study was then devised to test the effectiveness and safety of the monoclonal anti-body in the glioma treatment. Implantation of L2G7 under the skin was found to produce complete inhibition of the tumor while better results (tumor inhibition, tumor regression and enhanced survival rate) were seen following implantation in the brain.

The novel monoclonal anti-body, developed by Dr. Kim and his research team targeted the inhibition of hepatocyte growth factor (HGF), believed to play a major role in the further growth and spread of cancer by accelerating cell division, inducing formation of blood vessels and increasing resistance to chemotherapy drugs. The successful incorporation of the antibody, surpassing the 'blood-brain barrier' (BBB) proved to be a challenging task for the researchers.

Mice were treated with either L2G7 or a placebo, the results of which turned to be in favor of the monoclonal antibody, probably due to its specificity. The main advantage of this treatment modality is that it minimizes chances of neighboring tissue damage and the side effects.

Brain tumors account for significant mortality in children below 20 years of age. Conventional therapies have a very limited role to play in the treatment of brain tumors. The researchers have expressed hope over extrapolating the above finding which has already been proved successful in the treatment of lung, breast and colon cancer.


'"/>




Related medicine news :

1. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
2. Monoclonal antibodies show promise in treatment of blood cancer
3. Monoclonal Antibody based system for Anthrax detection
4. Monoclonal Antibody Reduces Exacerbations in Asthmatics
5. Survival of Mice With Human Breast Cancer Extended by Monoclonal Antibodies
6. Complete Robotic Surgery To Revolutionize Surgical Treatment of Prostate Cancer
7. LINK Applied Genomics Programme Promises To Revolutionize Healthcare Systems
8. Heart Stem Cells Could Revolutionize Cardiac Disease Therapy
9. Bio-Functional Garments That Could Revolutionize Fashion Industry
10. New Technique Could Revolutionize Melanoma Diagnosis and Treatment
11. Azathioprine Can Soon Revolutionize Eczema Treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... ... March 29, 2017 , ... ... squash, announced it has enlisted New York City-based sports and entertainment marketing firm ... and procure sponsorship opportunities for the Professional Squash Association (PSA), which includes first-time ...
(Date:3/29/2017)... ... March 30, 2017 , ... Grass pollen is the main cause of hay fever ... stuff. The season for grass pollen runs from May to July each year; with the ... victim to do? HayMax™ allergen barrier balms ( http://www.haymax.us ) provide an effective defense against ...
(Date:3/29/2017)... ... March 30, 2017 , ... Youth Futures International (YFI) premiered ... feedback from high school and college students who have participated in the program every ... and YFI is now accepting applications for enrollment. Visit http://www.ghana.yfiexperience.org to ...
(Date:3/29/2017)... ... March 30, 2017 , ... Sports Brand EXOUS Bodygear ... which retails normally at $29.97; for the remaining days of March, the price will ... reduced to a special price of just $10 (regular retail price $19.97). , The ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... Hours at a Walgreens store in Mississippi. AngioGenesis Labs, makers of HeartBoost, BrainBest ... in two southeastern states. Ingredients in HeartBoost, an over the counter heart healthy ...
Breaking Medicine News(10 mins):
(Date:3/30/2017)... Revenue Prospects by Product Type (Metered Dose Inhalers, Dry ... Respiratory Inhalers - our new study reveals trends, R&D progress, ... If you are involved in this sector you must read this ... revenues streams to 2027, assessing data, trends, opportunities and business prospects ... Discover how ...
(Date:3/29/2017)... NEW YORK , March 29, 2017 ... infection and promote healing of the wound. The industry ... devices and products for the treatment of wounds caused ... that occur due to diseases such as diabetes, skin ... Europe was the largest ...
(Date:3/29/2017)... , March 29, 2017  BioSpecifics Technologies Corp. ... continues to develop collagenase based-therapies with a first ... marketed as XIAFLEX ®  in the U.S. and ... present a corporate overview at the upcoming 16 ... April 5, 2017 at 8:00 a.m. ET in ...
Breaking Medicine Technology: