Navigation Links
Monoclonal Anti-Body To Revolutionize Brain Cancer Treatment

The use of monoclonal anti-body (mAb) L2G7 could revolutionize treatment of Glioma, the most common type of primary brain tumor. Surgery, chemotherapy and radiation are the only available treatment options for this type of cancer. // However, there is a significant risk of physical inability and cognitive impairment associated with these treatment forms. The results of the study can be found in the Clinical Cancer Research journal.

The anti-body was found to inhibit growth of the malignant glioma cells, inducing an attenuation of growth. Surprisingly, the survival rate was also extended. Following these promising findings, it is hoped that human clinical trials of the immunotherapy would be initiated soon.

Animal models (mice) were created to represent human models of the malignant disease by Dr. Jin Kim (Galaxy Biotech) and Dr. John Laterra (Kennedy Krieger Institute). A study was then devised to test the effectiveness and safety of the monoclonal anti-body in the glioma treatment. Implantation of L2G7 under the skin was found to produce complete inhibition of the tumor while better results (tumor inhibition, tumor regression and enhanced survival rate) were seen following implantation in the brain.

The novel monoclonal anti-body, developed by Dr. Kim and his research team targeted the inhibition of hepatocyte growth factor (HGF), believed to play a major role in the further growth and spread of cancer by accelerating cell division, inducing formation of blood vessels and increasing resistance to chemotherapy drugs. The successful incorporation of the antibody, surpassing the 'blood-brain barrier' (BBB) proved to be a challenging task for the researchers.

Mice were treated with either L2G7 or a placebo, the results of which turned to be in favor of the monoclonal antibody, probably due to its specificity. The main advantage of this treatment modality is that it minimizes chances of neighboring tissue damage and the side effects.

Brain tumors account for significant mortality in children below 20 years of age. Conventional therapies have a very limited role to play in the treatment of brain tumors. The researchers have expressed hope over extrapolating the above finding which has already been proved successful in the treatment of lung, breast and colon cancer.


'"/>




Related medicine news :

1. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
2. Monoclonal antibodies show promise in treatment of blood cancer
3. Monoclonal Antibody based system for Anthrax detection
4. Monoclonal Antibody Reduces Exacerbations in Asthmatics
5. Survival of Mice With Human Breast Cancer Extended by Monoclonal Antibodies
6. Complete Robotic Surgery To Revolutionize Surgical Treatment of Prostate Cancer
7. LINK Applied Genomics Programme Promises To Revolutionize Healthcare Systems
8. Heart Stem Cells Could Revolutionize Cardiac Disease Therapy
9. Bio-Functional Garments That Could Revolutionize Fashion Industry
10. New Technique Could Revolutionize Melanoma Diagnosis and Treatment
11. Azathioprine Can Soon Revolutionize Eczema Treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial Services, ... preparation services, is providing an update on a charitable event that began earlier ... is a locally recognized nonprofit that provides shelter and care for animals seeking ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, ... formed by Walgreens and pharmacy benefit manager Prime Therapeutics ... new brand, which included the unveiling of new signage ... , as well as at a few other company-owned ... new brand to patients, some of whom will begin ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology: