Navigation Links
Molecule responsible for age associated macular degeneration identified

CLEVELAND--A dart-like molecule that sticks to proteins in the eye is the main trigger for the unchecked growth of blood vessels, according to researchers at Case Western Reserve University and the Cleveland Clinic Cole Eye Institute. //Uncontrolled blood vessel growth is one of the main reasons for the development of age-related macular degeneration (AMD), the leading cause of blindness among people over 65 in the United States.

Robert Salomon and his graduate students Kutralanathan Renganathan and Liang Lu of Case's Department of Chemistry in the College of Arts and Sciences, found that the molecule, Carboxyethylpyrroles (CEPs), attaches to proteins found in the eye, triggering the uncontrolled growth of blood cells.

The Case researchers teamed up with Quteba Ebrahem Jonathan Sears, Amit Vasanji, John Crabb and Bela Anand-Apte and Xiaorong Gu (a Salomon group alumna), of Cleveland Clinic, to complete the study titled Carboxyethlpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration.'

The results of their collaborative work were published in the recent Proceedings of the National Academy of Science (PNAS).

AMD is a progressive disease that results in the severe loss of vision. The early stages of AMD are characterized as 'dry,' with the disease advancing to the 'wet form' as the retina, the part of the eye responsible for central vision, becomes infused with fluid from leaky new blood vessels, during a process called neovascularization. The unchecked blood vessel growth, or angiogenesis, in the retina accounts for 80% of the vision loss in the advanced stages of AMD.

The retina cells that detect light contain polyunsaturated fatty lipids that are exquisitely sensitive to damage by oxygen. Even in healthy eyes, these cells are renewed every ten days. The researchers at Case and Cleveland Clinic used a method developed by Salomon to specifical
'"/>




Page: 1 2

Related medicine news :

1. New Molecule that can stop the growth of Viruses
2. Puberty may be due to GPR54 gene and KiSS-1 Molecule
3. Molecule responsible for muscle repair identified
4. Molecule aids fight E. Coli Infections
5. Molecule That Aids Bacterial Infections Identified
6. Molecule Behind Multiple Sclerosis Discovered
7. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
8. Scientists Discover Prostate Cancer Triggering Molecule
9. Passion Fizzling Out? Blame The “Love Molecule
10. Sensor Can Detect "Unhealthy" Molecules In Breath
11. Polymer Molecule Layered On Carb Molecule to Increase Sensitivity
Post Your Comments:
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville ... health and fitness fair ¡Vive tu vida! Get Up! Get ... nutrition for better health and wellness for people of all ... open to the public, will be held at Dean Porter ... to 1:00 pm. , “¡Vive tu Vida! Get Up! ...
(Date:10/22/2014)... Springfield, Va. (PRWEB) October 22, 2014 For ... way to make money; it’s an extension of her life’s ... her latest venture as the owner of FirstLight HomeCare, make ... , “It’s important to me that my work makes a ... always harbored an entrepreneurial spirit, so after much research, I ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 The ... , which is dedicated to distribute health information ... healthcare delivery worldwide announced the development of six ... patients expect when receiving healthcare. These are an ... patient-centered care: “providing care that is respectful of ...
(Date:10/22/2014)... Cheap Hosting USA is among the most distinguished review ... that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the best cheap ... , “iPower is one of the most reliable hosting ... of useful products for new and old clients. What’s ... and a number of features which will appeal to ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Lintelus, Inc., ... Sr. Vice President of Sales, will be speaking on ... Meetings Technology Expo on October 28, at the Holiday ... hosting a booth as well as a Tech Demo ... Meeting can create a more engaging event experience. , ...
Breaking Medicine News(10 mins):Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2
... , , , GAINESVILLE, Fla., Dec. ... studied the amazing regenerative power of salamanders, trying to ... usually leave humans and other mammals paralyzed -- or ... Institutes of Health Grand Opportunity grant of $2.4 million, ...
... , WASHINGTON, Dec. 11 The controversy ... votes on the omnibus spending bill purportedly to attend ... finance system, two national campaign finance watchdogs said today. ... elected leaders to spend too much time fundraising when ...
... , , DALLAS, Dec. 11 ... on individualized rehabilitation for younger, more active cardiac patients, ... Jane Hamilton Heart and Vascular Hospital was recently awarded ... and Pulmonary Rehabilitation (AACVPR). The award acknowledges programs that ...
... While vaccines help prevent many diseases in the United ... says a new report from the Institute of Medicine ... Plan. The revised plan should include a strategy ... that wrote the report. In addition, it should ...
... in uncommitted relationships , FRIDAY, Dec. 11 (HealthDay ... no more likely than those in committed relationships to ... the study, University of Minnesota researchers analyzed the responses ... who were asked about their sexual behaviors and emotional ...
... ... the creation of its Clinical Safety and Pharmacovigilance Certificate Program. , ... Horsham, PA (Vocus) December 11, ... Clinical Safety and Pharmacovigilance Certificate Program . This is the third program developed by ...
Cached Medicine News:Health News:Effort to Regenerate Injured Spinal Cords Turns to a New Model 2Health News:Effort to Regenerate Injured Spinal Cords Turns to a New Model 3Health News:Effort to Regenerate Injured Spinal Cords Turns to a New Model 4Health News:Controversy Over Reid Fundraiser Exemplifies Need for Fair Elections 2Health News:Baylor Hamilton Heart Hospital Honored for Innovative Rehabilitation Program 2Health News:Baylor Hamilton Heart Hospital Honored for Innovative Rehabilitation Program 3Health News:IOM report on national vaccine plan 2Health News:IOM report on national vaccine plan 3Health News:Casual Sex Doesn't Cause Emotional Damage: Study 2Health News:Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program 2Health News:Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program 3
(Date:10/22/2014)... , Oct. 22, 2014 Moms are ... health trackers for themselves and their kids, according to ... Report: Health & Fitness Go Mobile for Moms, the ... Series. BabyCenter, the number 1 pregnancy and parenting web ... that 55 percent of moms surveyed say they can,t ...
(Date:10/22/2014)... YARDLEY, Pa. , Oct. 22, 2014 /PRNewswire/ ... of their animal health medications, a Global Pharmaceutical ... and Antares serialization technology and turnkey solution to ... Photo - http://photos.prnewswire.com/prnh/20141021/153438 ... The product that was serialized and aggregated by ...
(Date:10/22/2014)... -- Influenza will affect as many as 200,000 people this ... States as high as 49,000 people.  The main ... person to person in respiratory droplets of coughs and sneezes. ... but kills much fewer people each year than the Flu. ... including sweat, saliva, blood and other bodily fluids. The Ebola ...
Breaking Medicine Technology:BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4Xyntek and Antares Serialization Solution Protects Pets Too! 2WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2
... Corporation , the leading provider of real-time location ... its vice president - government business development, Chris Doran ... 2:45 p.m., June 1 at the VHA Real ... company also will demonstrate its RTLS solutions at Booth ...
... (Nasdaq: OPTR ) today announced that the Company ... June 8, 2011 at 11:00 a.m. Eastern Time at The ... http://photos.prnewswire.com/prnh/20090413/LA97352LOGO ) A live audio webcast of this ... Company,s website at www.optimerpharma.com . Replays of this presentation ...
Cached Medicine Technology:Awarepoint Vice President - Government Business Development Chris Doran to Speak at VHA Real Time Location Systems Conference 2011 2Optimer Pharmaceuticals to Present at the Jefferies 2011 Global Healthcare Conference 2
Available in Purple, orange, dark blue, yellow, gray, royal blue, green and light blue colors....
With a large white surface and a black X in the center, knockout really makes you look the heavyweight....
Icefire has ice crystals on the top of a cool blue iris....
This design features a solid red iris....
Medicine Products: