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Molecule aids fight E. Coli Infections

tigators are extrapolating in their conclusions when they compare one with the other," cautioned Dr. Eyal Raz, associate professor of medicine at the University of California, San Diego.

Beyond the potential furthering of understanding of the human response to E. coli, the research provides important insight into insect immunity, Hackett said."Insects related to fruitflies, like mosquitoes, can spread disease, and I think it's important to know how insects can become infected and how they defend against the infection to understand disease transmission by insects."

"For many infectious diseases like E. coli sepsis, tuberculosis and anthrax, the bacteria are taken up by white blood cells called macrophages. The disease states are related to the fact the microbes manipulate the cell once inside, and this causes the cells to release toxic molecules that try to kill the bacteria but can kill the person as well," Ezekowitz told UPI. "This work provides a method for using a simplified system in flies to work out how bacteria interact with the cell and then to devise ways to intervene on behalf of the cell and the infected host."


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