Navigation Links
Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced

A new class of hybrid virus that can identify, highlight and deliver genes to mice tumor cells have been developed by researchers // at the University of Texas M. D. Anderson Cancer Center. This new development, reported in the journal Cell, marks a milestone in cancer research as it could lead to novel treatment strategies for combating cancer.

As the technique increases the visibility of the cancer cells and makes it more accessible to treatment, it might allow precise monitoring of how certain anti-cancer agents work. 'In tumor-bearing mice, we show that this hybrid virus can target tumors systemically to deliver an imaging or therapeutic gene. The signal is specific only to tumors, so one can monitor drug effectiveness at the molecular level,' said Renata Pasqualini, the co-leader of the study.

The hybrid virus was created by a culmination of the biological characteristics and genetic components of an animal virus. The new hybrid virus named as AAV phage or AAVP can be used as a vehicle for delivery of specific genes targeted at tumors in mice produced through appropriate techniques.

This technique of genetically marking a tumor could eventually lead to a strategy for detection on a clinic-ready body scanner. The unique ability of the hybrid virus to deliver genes or other agents into the cells in addition to targeting specific tissues represents a distinct advantage. What surprised the researchers is that the hybrid viruses retained the properties of the parental viruses, from which they were derived.

'This is only a proof-of-concept, and although we have yet to translate these hybrid viruses for use in humans, we hope that this new system will have future clinical applications. In addition to the obvious biological interest, when the vector is refined for patient use, it could perhaps help us diagnose, monitor and treat human tumors more accurately,' said Wadih Arap, co-leader of the study.

As the n ext step, the researchers intend to design studies to evaluate the safety and efficacy of the hybrid vectors in animal models designed to mimic human models of cancer. If successful results are obtained, the research would concentrate on ways and means to adapt and optimize the AAVP-based tumor targeting for use in cancer patients.

The researchers referred to the new technique as a 'theragnostic' approach. In other words, it is a combination of the diagnostic and therapeutic modalities. With research such as this offering endless hope in the diagnosis and treatment of cancer, a cure for the disease is not very far.


'"/>




Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Molecular Basis Of ALS Found
7. New Molecular Treatment Identified To Treat Blood Cell Cancers
8. Researchers Find Molecular "Brake" to Cell Death
9. Solitons Could Power Molecular Electronics, Artificial Muscles
10. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
11. Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... ... January 23, 2017 , ... Zachary Cattell, President of ... a healthcare industry expert at the 2017 Sector Summit hosted by Ivy Tech ... Business host Gerry Dick, will feature an employer and an association representative from ...
(Date:1/23/2017)... , ... January 23, 2017 , ... "ProRandom is a set of camera tools that ... dynamic looks in Final Cut Pro X," said Christina Austin - CEO of Pixel Film ... two layers of text with video footage. ProRandom works by using a virtual camera ...
(Date:1/23/2017)... ... January 23, 2017 , ... “The Inn at the Mill”: a story of ... in her quest to become happy and content. , “The Inn at the Mill” ... also lived in Germany and Vermont and is now living in Berks County on Crow ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Some Infallible Characteristics of Christ”: a fascinating ... of Christ” is the creation of published author, Rev. Dr. Robert W. Thomas, the ... years, a preacher for over nineteen, a pastor for over fifteen years. He is ...
(Date:1/22/2017)... ... ... "Photo Cloud allows FCPX users to add favorited photos to any drop ... Christina Austin - CEO of Pixel Film Studios. , To begin, select a ... include scenes with one, three, four or five focus points. There are five included ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... The American Pharmacists Association (APhA) is excited ... Medically Underserved Areas Enhancement Act (H.R. 592) ... was previously introduced in the 114 th session ... through pharmacists and their patient care services. ... (R-KY), G.K. Butterfield (D-NC), Tom ...
(Date:1/23/2017)... Ahead of today,s trading session, Stock-Callers.com draws investors, attention ... the close: Kite Pharma Inc. (NASDAQ: KITE ), BioPharmX ... Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ). According to a ... January 20 th , 2017, down on the day by about ... now at: ...
(Date:1/23/2017)... January 23, 2017 Longer life expectancy and rising ... global market for medical device technologies. BCC Research reveals in ... Asia-Pacific region, should see strong growth due to rising ... incomes. Continue Reading ... ...
Breaking Medicine Technology: