Navigation Links
Molecular Flaw Detected in Aggressive Breast Cancers

A molecular flaw that lets loose a particularly aggressive from of breast cancer has been discovered by the researchers at Dana-Farber Cancer Institute. They suggest that targeting this flaw with selective drugs could help victims of this type of breast cancer. //

The team of researchers led by Qunyan Yu, MD, and Peter Sicinski, MD, PhD, of Dana-Farber details their finding in the January issue of Cancer Cell. They report that this particular growth flaw interacts with a mutated oncogene and triggers a potentially fatal type of breast cancer. This flaw is seen in 10 percent of all breast cancers. This flaw causes the overproduction of a protein called cyclin D1, which triggers CDK4 kinase. This is a "growth switch", which unleashes a virulent proliferation of cancer cells. "The development of cancer drugs like Gleevec and Iressa have shown that it is possible to block the action of kinases," said Sicinski, "so we hope that these findings will stimulate interest in developing drugs to block CDK4 as a targeted approach to treating this very aggressive cancer." Breast cancers, which have overactive cyclin D1- CDK4 as well as the mutated cancer-causing gene ErbB-2 (also known as HER-2) are next to impossible to detect. One study had found the seven-year survival rate of women affected by this type of cancer to be just 13 percent. In recent times, Herceptin has targeted the mutation and blocked it, thereby improving the prognosis for Her-2 positive women. Sicinski pointed out that a CDK4 inhibitor could be combined with Herceptin to benefit patients. "We are going to see in the next five years a movement away from treating all tumors with the same drugs, and instead match specific drugs to tumors based on their molecular characteristics," said Sicinski, an associate professor of pathology at Harvard Medical School.

Co-authors of the paper are from Linkoping University, Linkoping, Sweden; Biogen Idec, Cambridge, Mass.; and Northwestern University, Ch icago. For more information visit www.dana-farber.org Contact: Bill Schaller william_schaller@dfci.harvard.edu 617-632-5357 Dana-Farber Cancer Institute
'"/>




Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Computer Developed To perform Calculations From Within Human Body
5. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
6. Molecular Basis Of ALS Found
7. New Molecular Treatment Identified To Treat Blood Cell Cancers
8. Researchers Find Molecular "Brake" to Cell Death
9. Solitons Could Power Molecular Electronics, Artificial Muscles
10. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
11. Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2017)... ... June 22, 2017 , ... United Benefit ... welcome Whipple & Company as its newest Partner Firm. Headquartered in Coconut Creek, ... clients’ risk while tailoring optimized benefit packages that strengthen the relationship between employer ...
(Date:6/22/2017)... ... June 22, 2017 , ... Children’s National ... Heart Association (AHA) to launch a Rheumatic Heart Disease Center, with the goal ... of rheumatic heart disease (RHD) in high-risk, financially disadvantaged countries and low-income communities ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... environmental excellence. Maryland Recycling Network has awarded the Baltimore VA Medical Center, a ... Government Program Award for its efforts to promote waste reduction and promote recycling. ...
(Date:6/22/2017)... ... ... A June 12 article in The Star offers the advice ... oral hygiene by an aged parent who had recently suffered a series of minor ... steps, including scheduling a dentist visit. Northridge Dental Works, a Los Angeles Area dental ...
(Date:6/20/2017)... Murfreesboro, Tennessee (PRWEB) , ... June 20, 2017 ... ... chronic care services, announced today that Claritas Capital, a Nashville-based private equity firm, ... to accelerate our expansion plans for some time, and Claritas Capital offers the ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... 2017 Therapix Biosciences Ltd. (Nasdaq: TRPX), ... the development of cannabinoid-based drugs, today announced that ... at three upcoming scientific and investor conferences in ... Invitational: ...                     Wednesday, June ...
(Date:5/26/2017)... , May 26, 2017  Endo International plc (NASDAQ: ... President and CEO, will represent the Company in a fireside ... Conference on Tuesday, June 13, 2017 at 10:40 a.m. PT ... Terranea Resort in Rancho Palos Verdes, CA. ... the event will be available on the Company,s website at ...
(Date:5/24/2017)... , May 24, 2017  ivWatch LLC ... Equipment Manufacturer (OEM) Board to enable seamless integration ... patient monitoring systems, infusion pumps and other devices. ... will be able to help health care customers ... reduced risks related to IV therapy. ...
Breaking Medicine Technology: