Navigation Links
Molecular Flaw Detected in Aggressive Breast Cancers

A molecular flaw that lets loose a particularly aggressive from of breast cancer has been discovered by the researchers at Dana-Farber Cancer Institute. They suggest that targeting this flaw with selective drugs could help victims of this type of breast cancer. //

The team of researchers led by Qunyan Yu, MD, and Peter Sicinski, MD, PhD, of Dana-Farber details their finding in the January issue of Cancer Cell. They report that this particular growth flaw interacts with a mutated oncogene and triggers a potentially fatal type of breast cancer. This flaw is seen in 10 percent of all breast cancers. This flaw causes the overproduction of a protein called cyclin D1, which triggers CDK4 kinase. This is a "growth switch", which unleashes a virulent proliferation of cancer cells. "The development of cancer drugs like Gleevec and Iressa have shown that it is possible to block the action of kinases," said Sicinski, "so we hope that these findings will stimulate interest in developing drugs to block CDK4 as a targeted approach to treating this very aggressive cancer." Breast cancers, which have overactive cyclin D1- CDK4 as well as the mutated cancer-causing gene ErbB-2 (also known as HER-2) are next to impossible to detect. One study had found the seven-year survival rate of women affected by this type of cancer to be just 13 percent. In recent times, Herceptin has targeted the mutation and blocked it, thereby improving the prognosis for Her-2 positive women. Sicinski pointed out that a CDK4 inhibitor could be combined with Herceptin to benefit patients. "We are going to see in the next five years a movement away from treating all tumors with the same drugs, and instead match specific drugs to tumors based on their molecular characteristics," said Sicinski, an associate professor of pathology at Harvard Medical School.

Co-authors of the paper are from Linkoping University, Linkoping, Sweden; Biogen Idec, Cambridge, Mass.; and Northwestern University, Ch icago. For more information visit www.dana-farber.org Contact: Bill Schaller william_schaller@dfci.harvard.edu 617-632-5357 Dana-Farber Cancer Institute
'"/>




Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Computer Developed To perform Calculations From Within Human Body
5. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
6. Molecular Basis Of ALS Found
7. New Molecular Treatment Identified To Treat Blood Cell Cancers
8. Researchers Find Molecular "Brake" to Cell Death
9. Solitons Could Power Molecular Electronics, Artificial Muscles
10. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
11. Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2016)... ... May 30, 2016 , ... As the CDC relaxes ... children and their efforts to keep their households lice free. , According to ... enacting new policies that keep kids in the classroom despite the fact that they ...
(Date:5/30/2016)... ... May 30, 2016 , ... ... of FCPX," said Christina Austin - CEO of Pixel Film Studios. , ... Final Cut Pro X. Choose from abstract transitions to more simple wipes with ...
(Date:5/30/2016)... ... May 30, 2016 , ... ... announced today the publication of an original infographic, " Health Benefits Reimbursement Compliance ... professionals understand how Zane Benefits complies with various federal regulations and reforms. , ...
(Date:5/30/2016)... ... May 30, 2016 , ... Shaolin Institute officially starts the ... special intensive summer training camp starts on June 17th on Shaolin Institute Atlanta ... children a fun and unique experience with an opportunity to learn KungFu martial ...
(Date:5/30/2016)... ... May 30, 2016 , ... Another ER facility operated by First Choice ... Legacy Drive, Plano, TX and is open 24 hours daily. , First Choice Emergency ... medical open house. The Jasper High School band entertained attendees and accepted First Choice ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 Eye ... parents of premature babies to seek an eye examination ... blinding condition     Moorfields Eye Hospital ... in London , has identified premature babies as ... problems, because of their particular vulnerability to retinopathy of prematurity (ROP). ...
(Date:5/27/2016)...  A new study highlights the necessity of health literacy within the technology advancement ... College of Radiology , a majority of oncology patients undergo imaging screenings without understanding ... ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... Israel , May 27, 2016 ... of the Dario™ Diabetes Management Tool, today announced that the ... at the Marcum MicroCap Conference being held June 1-2 in ... Micro Invitational, being held June 7-9 in Los ... Ben-David will discuss recent corporate and operational milestones, including the ...
Breaking Medicine Technology: