Navigation Links
Molecular Basis of Obesity-Revealing the Unknown Facts

The same diet make some of us gain more weight than others- This could be due to the presence of a molecule called BSX, as scientists from the European Molecular Biology Laboratory [EMBL], the German Institute for Nutrition [DIFE], Potsdam, and the University of Cincinnati report in the current issue of Cell Metabolism.

Bsx is the molecular link between spontaneous physical activity and food intake. Mice lacking the molecule show less spontaneous physical activity, perceive hunger signals differently and have a lower concentration of feeding hormones in their brain than normal mice. Being conserved across species, Bsx might be a promising target for controlling diet-induced obesity in humans.

Spontaneous physical activity, subconscious movements we make such as fidgeting while working at the computer, and food intake are two crucial factors regulating our body weight. Both are controlled by the same part of the brain, called hypothalamus, and they are intrinsically linked. When we are hungry, our spontaneous activity increases and provides us with the drive to go out and find food. Mathias Treier and his group at EMBL have now discovered the molecule that brings about this link between locomotor activity and food intake in mice.

"The molecule is called Bsx and is required for spontaneous activity," Treier says. "Mice that lack Bsx in their hypothalamus are a lot lazier than normal mice. They show less spontaneous activity and less food seeking behaviour, which is based on locomotor activity."

Bsx brings about its effect by regulating the expression of NPY and AgRP, hormones of the hypothalamus that promote feeding. Without Bsx less hormones are made with the result that only rarely the mice go looking for food even if they have been starving for an extended period. The scientists suggest Bsx is also needed to enable brain cells to sense and respond to specific hunger signals from the body without it the mice do not feel hunger.

"Bsx is is conserved across species and very likely plays a similar role in controlling body weight in humans," says Maria Sakkou, who carried out the research in Treier's lab. "Differences in Bsx activity between individuals could help explaining why some people are intrinsically more active than others and less susceptible to diet-induced obesity. Bsx might be the key to why the same diet makes one person fat, while leaving another unaffected."

The insights gained into the molecular mechanisms regulating body weight in mice might serve as a basis for new ways to prevent obesity and resulting diseases such as cardiovascular conditions and diabetes in humans. Bsx is a promising candidate drug target and further research might suggest how it could be used to modulate basic physical activity as a way to protect against diet-induced obesity.


'"/>




Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
7. Molecular Basis Of ALS Found
8. New Molecular Treatment Identified To Treat Blood Cell Cancers
9. Researchers Find Molecular "Brake" to Cell Death
10. Solitons Could Power Molecular Electronics, Artificial Muscles
11. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/4/2016)... ... May 04, 2016 , ... Nike Rugby Camp's success is due ... Diego. Willis, founder of Elite Rugby Camps and current Nike Camp director, has offered ... since 2009. , ā€œIā€™m excited for our eighth summer here in San Diego,ā€ ...
(Date:5/4/2016)... ... ... Washington Wellness Center today announced its tenth anniversary of providing a complete approach to ... idea to provide a holistic approach to wellness has now become a growing trend ... Chiropractic Physician , the wellness center offers a complete range of services such ...
(Date:5/4/2016)... Watsonville, California (PRWEB) , ... May 04, 2016 ... ... powerful formulation of foundational nutrients that supports cellular and metabolic health. This synergistic ... and 400 mg free-form curcumin, along with 150 mg of reduced glutathione and ...
(Date:5/4/2016)... ... 04, 2016 , ... The preeminent surgical aftercare facility Pearl Recovery Retreat was ... surgery. In March 2016, the 61-year-old model and reality TV star was diagnosed with ... the milk ducts, according to an interview with the Daily Mail Online . ...
(Date:5/4/2016)... ... May 04, 2016 , ... Warren L. Smith M.D. , There ... UTIs, have plagued people since the beginning of recorded medical history, and in ... every year. It's not just a matter of inconvenience; bladder infections cost us billions ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... Leading Economies with Fastest Real GDP Annual Percentage Change, 2015  ... India 7.3, , Source: IMF and TechSci Research   ... Brazil , Russia , India ... registered the fastest GDP growth during the first decade of the 21 st ... Brazil and Russia , along with ...
(Date:5/2/2016)...  While nearly three-quarters of Americans (71%) are aware ... health, only about half report taking any steps to ... a new survey announced today by Hologic (Nasdaq: ... Osteoporosis Month, Hologic is raising awareness of this major ... Americans. Osteoporosis is a disease that causes ...
(Date:5/2/2016)... The global  ultrasound device ... by 2024, according to a new report published ... the sonography market include expanding applications of the ... periodic ultrasound screenings of the breast for breast ... ) High Intensity Focused Ultrasound (HIFU) ...
Breaking Medicine Technology: