Navigation Links
Molecular Basis of Obesity-Revealing the Unknown Facts

The same diet make some of us gain more weight than others- This could be due to the presence of a molecule called BSX, as scientists from the European Molecular Biology Laboratory [EMBL], the German Institute for Nutrition [DIFE], Potsdam, and the University of Cincinnati report in the current issue of Cell Metabolism.

Bsx is the molecular link between spontaneous physical activity and food intake. Mice lacking the molecule show less spontaneous physical activity, perceive hunger signals differently and have a lower concentration of feeding hormones in their brain than normal mice. Being conserved across species, Bsx might be a promising target for controlling diet-induced obesity in humans.

Spontaneous physical activity, subconscious movements we make such as fidgeting while working at the computer, and food intake are two crucial factors regulating our body weight. Both are controlled by the same part of the brain, called hypothalamus, and they are intrinsically linked. When we are hungry, our spontaneous activity increases and provides us with the drive to go out and find food. Mathias Treier and his group at EMBL have now discovered the molecule that brings about this link between locomotor activity and food intake in mice.

"The molecule is called Bsx and is required for spontaneous activity," Treier says. "Mice that lack Bsx in their hypothalamus are a lot lazier than normal mice. They show less spontaneous activity and less food seeking behaviour, which is based on locomotor activity."

Bsx brings about its effect by regulating the expression of NPY and AgRP, hormones of the hypothalamus that promote feeding. Without Bsx less hormones are made with the result that only rarely the mice go looking for food even if they have been starving for an extended period. The scientists suggest Bsx is also needed to enable brain cells to sense and respond to specific hunger signals from the body without it the mice do not feel hunger.

"Bsx is is conserved across species and very likely plays a similar role in controlling body weight in humans," says Maria Sakkou, who carried out the research in Treier's lab. "Differences in Bsx activity between individuals could help explaining why some people are intrinsically more active than others and less susceptible to diet-induced obesity. Bsx might be the key to why the same diet makes one person fat, while leaving another unaffected."

The insights gained into the molecular mechanisms regulating body weight in mice might serve as a basis for new ways to prevent obesity and resulting diseases such as cardiovascular conditions and diabetes in humans. Bsx is a promising candidate drug target and further research might suggest how it could be used to modulate basic physical activity as a way to protect against diet-induced obesity.


'"/>




Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
7. Molecular Basis Of ALS Found
8. New Molecular Treatment Identified To Treat Blood Cell Cancers
9. Researchers Find Molecular "Brake" to Cell Death
10. Solitons Could Power Molecular Electronics, Artificial Muscles
11. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/21/2017)... Austin, Texas (PRWEB) , ... January 21, 2017 ... ... surgeries performed by Austin, Texas Periodontist Dr. Dan Holtzclaw in media for its ... features two surgeries performed by Dr. Holtzclaw in which he utilizes creos™ ...
(Date:1/20/2017)... , ... January 20, 2017 , ... A new partnership ... items they no longer use or need, from clothes to couches to dressers and ... items and take them to the nearest Goodwill donation center through February 28th. ...
(Date:1/20/2017)... ... January 20, 2017 , ... Source Vitál Apothecary, a ... percent pure essential oils, announced the company had a successful visit to the 2017 ... ECRM event gives companies that work in the nutritional, sports and health industries a ...
(Date:1/20/2017)... ... January 20, 2017 , ... Bionic Sports Nutrition LLC, ... of life, announced it had a successful January ECRM Trade Show in Hilton Head, ... United States, which allows it to provide its products to all clients at reasonable ...
(Date:1/20/2017)... FL (PRWEB) , ... January 20, 2017 , ... ... and wellness products to enhance people’s everyday lives, recently attended the January ECRM ... buyers. , ATP Science is known for its large range of supplements that ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... According to a study conducted by Persistence Market Research ... CAGR of 6.5% during the forecast period 2016-2024. According to the ... the leading market for cryotherapy globally during the forecast period  ... Highlights from the Report  ... adequate supply of gas in order to provide smoother maintenance services ...
(Date:1/19/2017)... January 19, 2017 ... Oncology & Haematology, 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... Published recently in a supplement to ... from touchONCOLOGY, an article by James Gilbart ...
(Date:1/19/2017)... , January 19, 2017 Shire ... that the U.S. Food and Drug Administration (FDA) has ... New Drug Application (NDA) for SHP465, a long-acting, triple-bead, ... a potential once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). The ... around June 20, 2017, the designated Prescription Drug User ...
Breaking Medicine Technology: