Navigation Links
Molecular Basis Of ALS Found

ed up with Siddique and Deng. As reported in the second PNAS paper, they show that increased oxidative stress leads to the mutant SOD1 protein forming incorrect disulfide bonds early in its life. The researchers isolated and examined aggregates from the spinal cord of several ALS-model mice. In the diseased mice the scientists found intermolecular disulfide bonds that cross-linked SOD1 molecules together, resulting in the formation of insoluble aggregates. The SOD1 aggregates were specific to the spinal cord, the part of the body most damaged in ALS. Tissues unaffected by the disease, such as the brain and liver, had no aggregates.

Oxidation and protein aggregation have been suspected to play an important role in the pathogenesis of neurodegenerative disorders as well as in the normal aging process. However, the relationship between protein oxidation, protein aggregation and neurodegeneration remains unclear. The oxidative intermolecular disulfide cross-linking paradigm established by the Northwestern researchers provides direct links between protein oxidation, protein aggregation and neurodegeneration in SOD1-mediated ALS. This mechanism may play an important role not only in SOD1-mediated ALS but also in some other neurodegenerative disorders.

"For some time researchers have been thinking that copper, which causes the protein to be bluish-green in color, was the bad guy in this disease," said O'Halloran. "But the data has been building up to say that something else may be responsible for the toxicity. Our results suggest that the status of the disulfide bond, a long overlooked part of the SOD1 protein, plays a pivotal role. The ALS mutations appear to predispose SOD1 to form incorrect disulfide bonds that lead to aggregation of the protein and perhaps initiation of the disease. If these ideas are borne out, our next step is to look for therapeutic approaches that could prevent formation of the disulfide cross-linked aggregates." Source: Eur
'"/>




Page: 1 2 3 4

Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
7. New Molecular Treatment Identified To Treat Blood Cell Cancers
8. Researchers Find Molecular "Brake" to Cell Death
9. Solitons Could Power Molecular Electronics, Artificial Muscles
10. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
11. Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular Basis ALS Found

(Date:7/13/2014)... Micro irrigation systems are mainly utilized ... as wells as to maintain soil quality. The application ... become a dominant revenue generator for manufacturers in future. ... resource costs has led to the adoption of micro ... further caused massive demand for micro irrigation systems, as ...
(Date:7/13/2014)... Fuel additives are chemicals, which are added to ... and so on, in order to enhance their performance. ... effects caused by fuels and improving the combustion properties ... economies of scale in the long run, but, in ... the fuel products. , The various fuel additive types ...
(Date:7/13/2014)... New York, New York (PRWEB) July 13, 2014 ... much to bring attention to the cancer risks associated ... a chance to tell their story to federal regulators, ... of a U.S. Food & Drug Administration (FDA) ... Liebhard LLP reports. According to the Rochester Democrat ...
(Date:7/13/2014)... Athletes with a certain genetic make-up ... according to research presented today at the American Orthopaedic ... The research marks the first of its kind investigating ... physical events that occur after a head injury. ... in the (GT)n genotype were four times more likely ...
(Date:7/13/2014)... July 13, 2014 Max International ... Chris Mullin, will be the featured guest at its ... in Puerto Rico. Attendees will learn about Max’s ... in two exhibition basketball games and perform in a ... supplier of health- and energy-boosting supplements , has recently ...
Breaking Medicine News(10 mins):Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 3Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 4
... BANGKOK, Oct. 6 As thousands of experts around ... health and nutrition at the International Congress of Nutrition ... and Mars, Incorporated are acknowledging the important impact of ... Science - Flavanols and Sustainability," scientists will present evidence ...
... Blue Cross and Blue Shield ("Anthem") announced today ... Care Incentive Program. The program is designed to ... care physician group practices that meet identified industry ... recognitions and technology adoption aimed at enhancing patient ...
... Panel Intelligence, LLC, is pleased to announce expanded capabilities ... Panel Intelligence has provided actionable market intelligence in the ... professionals. Panel Intelligence has now significantly expanded ... service provides cancer therapeutics companies with direct access to ...
... available in <A HREF=",http://chinese.eurekalert.org/zh/emb_releases/2009-10/jaaj-gvo100209.php,">Chinese . Among ... a certain enzyme appears to be associated with clinical ... study in the October 7 issue of JAMA ... for the last 25 years for endocrine treatment of ...
... leading brand in the weight management industry, launched Metabolife "Less ... positive, incremental changes to their lives and the lives of ... the launch of www.joinlessismore.com . , "Metabolife ... that delivers lasting results and weight loss is just one ...
... 6 Between $30 billion and $34 billion reside ... companies in bankruptcy to pay claims brought by workers ... last month,s "National Asbestos Litigation Conference" produced in San ... featured panels of state court judges from around the ...
Cached Medicine News:Health News:Cocoa Research Finds a Place in the Global Health Dialogue 2Health News:Cocoa Research Finds a Place in the Global Health Dialogue 3Health News:Cocoa Research Finds a Place in the Global Health Dialogue 4Health News:Cocoa Research Finds a Place in the Global Health Dialogue 5Health News:Anthem Blue Cross and Blue Shield Introduces 'Quality-In-Sights(R)' Primary Care Incentive Program to Improve Quality and Safety of Patient Care 2Health News:Anthem Blue Cross and Blue Shield Introduces 'Quality-In-Sights(R)' Primary Care Incentive Program to Improve Quality and Safety of Patient Care 3Health News:Panel Intelligence Develops Extensive Access to Patient Populations in Oncology 2Health News:Genetic variation of enzyme linked with outcomes for women receiving tamoxifen 2Health News:Communities Nationwide Learn 'Less Is More' from Metabolife(R) Through 1,000 In-Home Parties and An Interactive Site www.joinlessismore.com 2Health News:Communities Nationwide Learn 'Less Is More' from Metabolife(R) Through 1,000 In-Home Parties and An Interactive Site www.joinlessismore.com 3Health News:Asbestos Trusts, Asbestos Judges Featured at Two HB Events Dec. 2 & 3 2
(Date:7/11/2014)... /PRNewswire-iReach/ -- VAPETEK™, Inc. has announced a new ... in portable vaporizers, which contains CBD, or cannabodiol. ... cannabidiol offers consumers a THC-free product made for ... technology. Photo - http://photos.prnewswire.com/prnh/20140711/126344 ... compounds which are currently known, two of which ...
(Date:7/11/2014)... July 11, 2014 The consumer marketing ... across industry sectors to better identify winning tools ... to engage with and understand consumers, as new ... make critical purchasing decisions. According ... LLC, one area where organizations can observe a ...
(Date:7/11/2014)... 11, 2014 Research and Markets ... Chinese Medical X-ray Film Industry Report 2014" report ... Global And Chinese Medical X-Ray Film ... on the current state of the Global medical X-ray ... The report provides a basic overview of the ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Technologies Transforming Consumer Marketing Research Playbook 2Global and Chinese Medical X-ray Film Industry Report 2014 2
... WELLESLEY, Mass., Oct. 26 Coley,Pharmaceutical Group, Inc. ... company,has received a $3.0 million milestone payment from ... III clinical trial in,non-small cell lung cancer (NSCLC) ... adjuvant. In June 2007, GSK announced the ...
... at AACR-NCI-EORTC ... Symposium, ... MTAX: CTIC) and Systems Medicine, LLC (SM), a,wholly-owned subsidiary of CTI, ... 19th annual AACR-NCI-EORTC Symposium. "These studies show potential progress toward ...
Cached Medicine Technology:Coley Pharmaceutical Group Receives $3.0 Million Milestone Payment from GlaxoSmithKline 2Coley Pharmaceutical Group Receives $3.0 Million Milestone Payment from GlaxoSmithKline 3Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development 2Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development 3Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development 4Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development 5
Inquire...
Integrated closure system provides security you can feel as the plastic fasteners lock into place and is both easy to close, empty and clean....
Flextend is a hydrocolloid skin barrier that is designed to be the most resistant to discharge and is the barrier of choice for urostomies and high output ileosotomies....
Inquire...
Medicine Products: