Navigation Links
Molecular Basis Of ALS Found

not know if these aggregates are causative, harmless or even beneficial to ALS. Furthermore, the fundamental molecular mechanism by which the SOD1 mutants form aggregates is not clear.

Six years ago Siddique and Han-Xiang Deng, M.D., associate professor of neurology at the Feinberg School, started to develop and analyze various SOD1 transgenic mouse models and found, as they report in the first of the two PNAS papers, that aggregated and insoluble SOD1 is the pathogenic form that causes disease. The aggregation takes place in mitochondria, the powerhouse of the cell, which becomes damaged.

"We also have discovered a mechanism whereby 'normal' molecules of SOD1 are recruited in the presence of mutant SOD1 proteins to participate in the pathogenesis of ALS by forming intermolecular disulfide bonds," said Siddique. "This phenomenon is in some ways akin to the recruitment noted in prion disorders and provides molecular sites for therapeutic intervention." This molecular mechanism also may help explain other types of ALS in which no mutations have been detected in SOD1.

The normal form of SOD1 is a molecule composed of two identical parts, each with an amino acid chain, a copper ion, a zinc ion and an intramolecular disulfide linkage -- a bond within an SOD1 molecule that stabilizes the structure. Intermolecular disulfide bonds, or cross-links, are incorrect bonds that form between, not within, SOD1 molecules.

"A year ago we demonstrated that ALS mutations have the greatest effect on the most immature form of the SOD1 protein, causing it to misfold and form incorrect disulfide bonds that facilitate protein aggregation," said Thomas V. O'Halloran, professor of chemistry. "Those were test tube experiments, but we really wanted to know if we would find the same process in a physiological environment." To investigate their hypothesis further, O'Halloran and Yoshiaki Furukawa, formerly a post-doctoral fellow in O'Halloran's lab, team
'"/>




Page: 1 2 3 4

Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
7. New Molecular Treatment Identified To Treat Blood Cell Cancers
8. Researchers Find Molecular "Brake" to Cell Death
9. Solitons Could Power Molecular Electronics, Artificial Muscles
10. Discovery of Agile Molecular Motors Could Aid in Treating Motor Neuron Diseases
11. Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular Basis ALS Found

(Date:8/4/2015)... , ... August 04, 2015 , ... ... which provides vascular, electrocardiogram (EKG), echocardiogram, and NCV testing, announced their collegiate ... successfully identifying previously undiagnosed cardiovascular abnormalities one program at a time. ...
(Date:8/4/2015)... ... August 04, 2015 , ... Angelina Jolie is in ... millions of women every year. Dr. Angela DeRosa, DO, MBA, CPE aka ... therapies, takes the scary unknown out of menopause. , Myth #1: Menopause only ...
(Date:8/4/2015)... Diego, CA (PRWEB) , ... August 04, 2015 ... ... the Rise of Local Food,” scheduled for Nov. 3 – 4, 2015, at ... grow food sustainably, create new businesses, improve food access, and manage resources efficiently ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... 24/7 ... County, Los Angeles, Riverside, and San Bernardino, today announced that the U.S. Department of ... indicate that 24/7 Care At Home’s agency is well on the path to meeting ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... label design, product packaging, and fulfillment services, joined over 200 other Long Island-based ... was held on Tuesday, July 28th at Jones Beach State Park in Wantagh, ...
Breaking Medicine News(10 mins):Health News:Colleges and High Schools Across the Country Are Joining the Wimbledon U Team Uncovering Unknown Cardiac Conditions and Promoting Heart Healthy Athletes 2Health News:Colleges and High Schools Across the Country Are Joining the Wimbledon U Team Uncovering Unknown Cardiac Conditions and Promoting Heart Healthy Athletes 3Health News:"Dr. Hot Flash" Debunks the Top 5 Menopause Myths 2Health News:"Dr. Hot Flash" Debunks the Top 5 Menopause Myths 3Health News:Diversity of Urban and Hydroponic Farms of the Future to Highlight Seedstock Annual Conference Field Trip 2Health News:Diversity of Urban and Hydroponic Farms of the Future to Highlight Seedstock Annual Conference Field Trip 3Health News:24/7 Care At Home Receives Two Stars from the VA 2Health News:24/7 Care At Home Receives Two Stars from the VA 3Health News:NutraScience Labs "Steps Up" to the 2015 Marcum Workplace Challenge 2
... President Obama and Secretary of State Clinton on today,s nomination ... the Global AIDS Coordinator (OGAC). AIDS Action is pleased ... led by such an accomplished HIV medical expert with extensive ... including the epidemic here in the United States. We ...
... 2009 (BRONX, NY) A laboratory study by researchers ... that an anti-cancer compound studied for treating blood cancers may ... The work is reported in the April 28th online edition ... neck cancer refers to tumors in the mouth, throat, or ...
... Findings from clinical studies used to gain Food and ... most patients with depression, according to a report led by ... in the May issue of the American Journal of ... people with depression qualify for these studies, and those who ...
... With growing concerns about the current spread of ... face masks protect against swine flu?"Tony Hanson, Managing Director ... an innovative, technologically advanced system of medical face masks ... this time it is believed that the current strain ...
... Inc. today announced that it named Dr. Robert Ruffolo, ... leader in pharmaceutical research to its Scientific Advisory Board. ... Development in 2008, and currently serves as a consultant ... and has been responsible for all pharmaceutical research and ...
... Embrace Use of Targeted Agents Despite Their High ... WALTHAM, Mass., April 28 Decision Resources, one ... focusing on pharmaceutical and healthcare issues, finds that ... Indian brand/generics (capecitabine) will dominate the Indian colorectal ...
Cached Medicine News:Health News:AIDS Action Applauds Selection of Dr. Eric Goosby as Global AIDS Coordinator 2Health News:Experimental drug shows promise against head and neck cancer 2Health News:Are we cherry picking participants for studies of antidepressants? 2Health News:Will Face Masks Protect Against Swine Flu? 2Health News:Gene Network Sciences Names Former Wyeth President of R&D Robert Ruffolo to SAB 2Health News:Gene Network Sciences Names Former Wyeth President of R&D Robert Ruffolo to SAB 3Health News:Sanofi-Aventis' and Roche/Chugai's Drugs Will Dominate the Indian Colorectal Cancer Drug Market Through 2013 2
(Date:8/4/2015)... DUBLIN , Aug. 4, 2015 /PRNewswire/ ... announced the addition of Jain PharmaBiotech,s new ... Markets, and Companies" to their offering. ... transdermal drug delivery - an approach used ... therapeutic use as an alternative to oral,intravascular, ...
(Date:8/4/2015)... Concord Medical Services Holdings Limited ("Concord Medical", or the "Company") ... operator of the largest network of radiotherapy and diagnostic imaging ... will release its financial results for the second quarter of ... Management will hold a conference call to discuss the ... 18, 2015 (8:00 p.m. in Beijing / ...
(Date:8/4/2015)... , August 4, 2015 ... with market overview, trends, DRO analysis, market segmentation, ... competitive scenario and top competitor profiles in: ... Testing Market Development and Demand Forecast to 2020  ... Explore full reports with detailed TOC ...
Breaking Medicine Technology:Transdermal Drug Delivery Report 2015-2024 - Technologies, Markets, and Companies Analysis 2Concord Medical to Report Second Quarter 2015 Financial Results on August 17, 2015 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 4Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 5
... The American College of Medical Genetics (ACMG) ... decision to make Critical Congenital Cyanotic Heart Disease (CCCHD) ... Secretary,s Advisory Committee on Heritable Disorders in Newborns and ... MD, FACMG had made the recommendations to Secretary Kathleen ...
... 2011 Visionsense Corp announces an unique milestone this ... 500th neurosurgical procedure with the VSii system. ... Vice-Chairman, Dept of Neurosurgery at Emory University and Professor ... of a pituitary adenoma in the morning of September ...
Cached Medicine Technology:American College of Medical Genetics Applauds HHS Secretary's Decision to Expand Newborn Screening to Include Critical Congenital Heart Disease 2
... the only dura material versatile enough for ... closure, and in cases where biological fixation ... in cases requiring an immediate watertight seal ... biological fixation and sealing are key factors ...
The Bovie IDS Series are the latest electrosurgical generators with fully digital implementation....
Aaron 1250 is a multipurpose electrosurgical generator with monopolar and bi-polar functions....
Bipolar foot activated forceps....
Medicine Products: