Navigation Links
Modified Herpes Virus Keeps Arteries Free-flowing Following Procedures

A genetically engineered herpes simplex virus, primarily known for causing cold sores, may help keep arteries free-flowing in the weeks following angioplasty or stent placement for patients, according to research published early in the online edition of PNAS (Proceedings of the National Academy of Sciences of the United States of America).

Christopher Skelly, MD, assistant professor of vascular surgery at the University of Chicago Medical Center, and the studys lead author says, One of the drawbacks of balloon angioplasty to open blocked arteries and the use of stents to keep them open is that arteries sometimes experience aggravation from the procedure. The balloon angioplasty, in addition to opening the artery can lead to smooth muscle cell proliferation, similar to formation of scar tissue, known as neointimal hyperplasia. This scar tissue can restrict blood flow not long after the procedures, leading to a recurrence of symptoms. A significant number of these cases end up requiring further intervention to address this complication.

Researchers at the University of Chicago noted that in recent years, genetically engineered herpes simplex virus studied for its efficacy against malignant tumors of the central nervous system and the liver was blocking certain types of cell death and proliferation of surviving cells. They wanted to test this effect in arteries following angioplasty therapy.

The researchers studied a rabbit model that replicates the restenosis or renarrowing after angioplasty. Rabbits that underwent angioplasty alone experienced significant narrowing of the artery. Rabbits exposed to the herpes simplex virus during angioplasty had minimal changes in the arteries. The smooth muscle cell proliferation which causes the restenosis was very low in the group treated with herpes and remained high in the untreated group.

One undesirable, yet expected outcome of angioplasty and stent placement is the disr uption of the arterys endothelial layer, which forms the inner lining of the artery. Loss of this inner layer predisposes the artery to blood clot formation which has been a recent concern with drug eluting stents. The researchers found that the endothelial layer was partially restored at 14 days and completely restored at 28 days post-balloon angioplasty in the group treated with the herpes virus.

The ability to target the smooth muscle cells that cause the narrowing, and regenerate the endothelial cell lining is an important finding, noted Skelly.

This study is an important step in the application of genetically engineered herpes simplex viruses for treatment of vascular disease," Skelly added. "It suggests that genetically engineered viruses may have a significant impact on the outcomes of angioplasty performed in humans. Human trials would be the next step to test this theory.


'"/>




Related medicine news :

1. Modified antibiotic may support fight cancer
2. Malaria To Be Tackled By Genetically Modified Mosquitoes
3. Stroke Rehabilitation Through Modified Video Games
4. Genetically Modified Cells Attack Tumors
5. TB can Be Eradicated in the U.S With Modified Guidelines: Study
6. Modified Ligament Surgery Improves Outcomes Players, Athletes
7. Modified Drug Therapy for Alzheimers Disease
8. Drug Stops Herpes
9. Drug Found To Reduce The Transmission Of Herpes
10. Cancer Causing Herpes Virus At Last May Have A Cure
11. Treating Latent Herpes With Licorice
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2016)... Bluffton, S. C. (PRWEB) , ... February 13, 2016 , ... Hidden Cypress in Sun ... in the area of facial plastic surgery. Dr. Frederick Weniger will be hosting ... facial rejuvenation at this event, and there will be special pricing on offers. In addition, ...
(Date:2/13/2016)... ... ... Many individuals looking to lead a healthy lifestyle have decreased carbohydrate consumption and ... Fitness has delved into this niche allowing those giving up their beloved pasta a ... 30 grams of protein and only 7 grams of carbohydrates per 50 gram serving--a ...
(Date:2/13/2016)... ... February 13, 2016 , ... In its newly released ... visualization technology should be used to ensure patient safety when placing an IV ... Standards mandate the use of vein visualization technology in patients with difficult venous ...
(Date:2/13/2016)... ... February 13, 2016 , ... In the early or “honeymoon” stage of ... perfection, go out of their way to be romantic, and may exaggerate a strength ... at any online dating profile. , A recent study from Queendom.com , ...
(Date:2/12/2016)... ... , ... Mystic Buddha Publishing House presents Valentine’s Day tips on different forms ... - Dr. Frederick Lenz. , According to Publisher Roger Cantu, “Blue Skies ... teaching and helping others. Valentine’s Day celebrates love in all its forms, and ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016 On Thursday, Feb. 11, ... at St. David,s North Austin Medical Center successfully completed ... Xi ® Surgical System with Trumpf Medical,s ... Thiru Lakshman , M.D., colorectal surgeon at the ... utilizing Integrated Table Motion technology, which seamlessly combines the ...
(Date:2/12/2016)... , Feb. 12, 2016  Eli Lilly and Company ... Court decided the Alimta® (pemetrexed disodium) vitamin regimen patent would ... the UK, France , Italy ... to dilute the product only with dextrose solution.  ... 2015, the UK Court of Appeal held that Lilly,s patent ...
(Date:2/12/2016)... Feb. 12 2016  OMS Supply, a large provider ... practitioners, announced today the recent launching of their new ... variety of features that enhance the user experience and ... --> --> ... new company that started in early 2016, they have ...
Breaking Medicine Technology: